ENSG00000115306

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333896 ENSG00000115306 HEK293_OSMI2_2hA HEK293_TMG_2hB SPTBN1 protein_coding protein_coding 23.34399 17.74645 24.597 0.887616 0.4877828 0.4707256 4.4863056 0.8077172 6.09277154 0.8077172 0.35358301 2.8997907 0.17953333 0.04170000 0.2482000000 0.20650000 7.224692e-02 6.598683e-10 FALSE TRUE
ENST00000356805 ENSG00000115306 HEK293_OSMI2_2hA HEK293_TMG_2hB SPTBN1 protein_coding protein_coding 23.34399 17.74645 24.597 0.887616 0.4877828 0.4707256 4.3425267 1.7422815 5.19195142 0.5859495 0.48658204 1.5698184 0.17670417 0.09570000 0.2113666667 0.11566667 4.636804e-02 6.598683e-10 FALSE TRUE
ENST00000389980 ENSG00000115306 HEK293_OSMI2_2hA HEK293_TMG_2hB SPTBN1 protein_coding protein_coding 23.34399 17.74645 24.597 0.887616 0.4877828 0.4707256 0.3786288 0.0000000 1.39111735 0.0000000 0.36884799 7.1304340 0.01432083 0.00000000 0.0560666667 0.05606667 6.598683e-10 6.598683e-10 FALSE TRUE
ENST00000496323 ENSG00000115306 HEK293_OSMI2_2hA HEK293_TMG_2hB SPTBN1 protein_coding retained_intron 23.34399 17.74645 24.597 0.887616 0.4877828 0.4707256 0.3419170 1.4474864 0.02337684 0.7093477 0.01655052 -5.4484914 0.01912917 0.08483333 0.0009666667 -0.08386667 1.749802e-02 6.598683e-10 FALSE TRUE
MSTRG.18390.3 ENSG00000115306 HEK293_OSMI2_2hA HEK293_TMG_2hB SPTBN1 protein_coding   23.34399 17.74645 24.597 0.887616 0.4877828 0.4707256 9.5243863 9.6904772 7.42870041 1.1174824 0.54453738 -0.3830051 0.42131250 0.54253333 0.3021666667 -0.24036667 1.430794e-04 6.598683e-10 FALSE TRUE
MSTRG.18390.8 ENSG00000115306 HEK293_OSMI2_2hA HEK293_TMG_2hB SPTBN1 protein_coding   23.34399 17.74645 24.597 0.887616 0.4877828 0.4707256 2.6494607 2.6463283 2.18077991 0.4298102 1.02887148 -0.2779889 0.11225417 0.15226667 0.0875000000 -0.06476667 5.132362e-01 6.598683e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115306 E001 2.7431401 0.0681285956 3.268187e-01 4.702701e-01 2 54456317 54456326 10 + 0.628 0.473 -0.721
ENSG00000115306 E002 13.3884568 0.0013532030 1.968767e-03 7.128357e-03 2 54456327 54456518 192 + 1.250 1.000 -0.896
ENSG00000115306 E003 1.4298538 0.0123309705 1.882160e-01 3.114969e-01 2 54457180 54457260 81 + 0.461 0.251 -1.271
ENSG00000115306 E004 1.7286183 0.0078070454 7.804161e-02 1.563283e-01 2 54457261 54457269 9 + 0.536 0.251 -1.634
ENSG00000115306 E005 0.5932625 0.1342898257 8.914453e-02 1.738228e-01 2 54457270 54457307 38 + 0.318 0.000 -11.242
ENSG00000115306 E006 0.5244761 0.2370171113 7.902231e-01 8.658096e-01 2 54457393 54457487 95 + 0.188 0.146 -0.447
ENSG00000115306 E007 0.6266857 0.0179942951 8.003018e-01 8.727035e-01 2 54457987 54458177 191 + 0.188 0.251 0.533
ENSG00000115306 E008 0.0000000       2 54515744 54516341 598 +      
ENSG00000115306 E009 57.8518663 0.0030367064 1.773007e-11 3.541659e-10 2 54526372 54526566 195 + 1.886 1.560 -1.106
ENSG00000115306 E010 0.1482932 0.0414590298 3.822413e-01   2 54526567 54528715 2149 + 0.000 0.143 10.032
ENSG00000115306 E011 58.8809693 0.0010083373 6.759643e-14 1.967118e-12 2 54558394 54558887 494 + 1.895 1.564 -1.122
ENSG00000115306 E012 113.3952268 0.0130570406 1.627994e-08 1.929637e-07 2 54599092 54599243 152 + 2.174 1.855 -1.071
ENSG00000115306 E013 128.2974774 0.0019885367 1.066988e-18 5.876096e-17 2 54612161 54612334 174 + 2.220 1.919 -1.007
ENSG00000115306 E014 96.5092975 0.0062105289 2.768560e-09 3.784511e-08 2 54616207 54616298 92 + 2.088 1.813 -0.923
ENSG00000115306 E015 96.3400036 0.0003125574 7.317044e-23 6.399779e-21 2 54617608 54617688 81 + 2.107 1.774 -1.120
ENSG00000115306 E016 124.2812079 0.0018962276 2.973682e-20 1.955415e-18 2 54618078 54618193 116 + 2.213 1.895 -1.065
ENSG00000115306 E017 121.2056457 0.0090289635 1.731837e-08 2.042910e-07 2 54621400 54621512 113 + 2.189 1.917 -0.913
ENSG00000115306 E018 173.3190140 0.0117524299 1.178658e-08 1.434309e-07 2 54622300 54622487 188 + 2.347 2.060 -0.960
ENSG00000115306 E019 143.6189256 0.0004930291 3.344776e-26 4.051520e-24 2 54623479 54623596 118 + 2.269 1.972 -0.992
ENSG00000115306 E020 182.6305618 0.0002081672 6.971948e-33 1.445093e-30 2 54624804 54624962 159 + 2.368 2.082 -0.956
ENSG00000115306 E021 214.6507850 0.0016384234 3.618964e-24 3.652647e-22 2 54625932 54626234 303 + 2.436 2.160 -0.922
ENSG00000115306 E022 139.0206418 0.0023336512 2.387421e-13 6.435540e-12 2 54628097 54628250 154 + 2.236 1.999 -0.792
ENSG00000115306 E023 439.5721291 0.0059730563 1.333196e-06 1.077977e-05 2 54628933 54629803 871 + 2.701 2.558 -0.477
ENSG00000115306 E024 168.7150906 0.0021858826 6.796719e-03 2.069460e-02 2 54629892 54630029 138 + 2.247 2.200 -0.155
ENSG00000115306 E025 463.0096394 0.0031720214 2.491608e-09 3.432180e-08 2 54630855 54631611 757 + 2.721 2.585 -0.453
ENSG00000115306 E026 257.2469222 0.0024788792 6.490138e-06 4.502974e-05 2 54632566 54632768 203 + 2.452 2.353 -0.327
ENSG00000115306 E027 190.1104903 0.0006044465 1.117243e-03 4.360942e-03 2 54637713 54637803 91 + 2.297 2.254 -0.144
ENSG00000115306 E028 210.9436106 0.0008789199 4.446340e-03 1.438948e-02 2 54642983 54643129 147 + 2.337 2.306 -0.105
ENSG00000115306 E029 279.4076295 0.0001989978 3.933160e-02 8.978711e-02 2 54644323 54644586 264 + 2.443 2.446 0.011
ENSG00000115306 E030 0.2955422 0.0290327349 8.514764e-01   2 54644587 54644590 4 + 0.104 0.143 0.532
ENSG00000115306 E031 0.0000000       2 54645157 54645158 2 +      
ENSG00000115306 E032 247.8781929 0.0001942377 8.900894e-02 1.736127e-01 2 54645229 54645453 225 + 2.389 2.398 0.031
ENSG00000115306 E033 156.3071752 0.0002299850 1.405520e-01 2.487960e-01 2 54645928 54646017 90 + 2.194 2.200 0.020
ENSG00000115306 E034 260.4189624 0.0002026151 2.638452e-01 4.017577e-01 2 54646194 54646475 282 + 2.405 2.428 0.078
ENSG00000115306 E035 191.1522641 0.0036814639 3.944480e-01 5.382780e-01 2 54647131 54647261 131 + 2.241 2.321 0.269
ENSG00000115306 E036 270.9870813 0.0008017589 1.947081e-01 3.196324e-01 2 54648986 54649184 199 + 2.392 2.473 0.269
ENSG00000115306 E037 99.0555555 0.0069253247 9.614047e-01 9.797010e-01 2 54649185 54649190 6 + 1.972 2.022 0.168
ENSG00000115306 E038 0.2966881 0.0293492344 2.815064e-01   2 54649572 54649577 6 + 0.188 0.000 -10.242
ENSG00000115306 E039 404.0021022 0.0002393266 3.753103e-02 8.646545e-02 2 54649615 54649989 375 + 2.564 2.652 0.291
ENSG00000115306 E040 2.1057541 0.0118814289 1.147026e-01 2.123990e-01 2 54652518 54653608 1091 + 0.318 0.617 1.536
ENSG00000115306 E041 256.9756689 0.0001703188 6.261833e-05 3.442600e-04 2 54653609 54653853 245 + 2.342 2.480 0.461
ENSG00000115306 E042 228.4450008 0.0002230024 1.547769e-02 4.157914e-02 2 54655070 54655208 139 + 2.305 2.412 0.355
ENSG00000115306 E043 237.2948356 0.0001886078 1.920682e-03 6.979565e-03 2 54655914 54655998 85 + 2.315 2.436 0.404
ENSG00000115306 E044 311.5668964 0.0001944392 2.413202e-05 1.469257e-04 2 54657850 54658046 197 + 2.425 2.561 0.452
ENSG00000115306 E045 236.3062079 0.0019614649 2.185129e-02 5.537120e-02 2 54659154 54659266 113 + 2.314 2.433 0.396
ENSG00000115306 E046 179.7222342 0.0015682481 5.497817e-03 1.728120e-02 2 54659936 54659999 64 + 2.186 2.323 0.458
ENSG00000115306 E047 193.2541483 0.0136753206 2.793423e-02 6.788342e-02 2 54660000 54662308 2309 + 2.191 2.382 0.638
ENSG00000115306 E048 28.2574497 0.0093996356 6.778855e-05 3.694786e-04 2 54662901 54664452 1552 + 1.574 1.294 -0.966
ENSG00000115306 E049 322.1871094 0.0014598991 5.494135e-05 3.063839e-04 2 54664453 54664691 239 + 2.431 2.587 0.519
ENSG00000115306 E050 252.7277776 0.0008884455 4.336975e-12 9.573839e-11 2 54665915 54666088 174 + 2.284 2.514 0.767
ENSG00000115306 E051 143.3048450 0.0002581709 4.601142e-12 1.011661e-10 2 54667604 54667646 43 + 2.018 2.276 0.862
ENSG00000115306 E052 1216.0676663 0.0091252217 6.526603e-29 9.995516e-27 2 54668351 54671446 3096 + 2.762 3.295 1.772