ENSG00000115290

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000446413 ENSG00000115290 HEK293_OSMI2_2hA HEK293_TMG_2hB GRB14 protein_coding protein_coding 3.212515 3.071536 3.226169 0.269513 0.2311284 0.07063695 0.07437383 0.0000000 0.24728864 0.00000000 0.24728864 4.6853159 0.02140833 0.0000000 0.06806667 0.06806667 0.82243533 0.04386232 FALSE FALSE
ENST00000488342 ENSG00000115290 HEK293_OSMI2_2hA HEK293_TMG_2hB GRB14 protein_coding retained_intron 3.212515 3.071536 3.226169 0.269513 0.2311284 0.07063695 1.49816752 0.9318650 1.87745058 0.23510898 0.28829324 1.0028466 0.48115833 0.2962667 0.59870000 0.30243333 0.13839205 0.04386232 TRUE TRUE
ENST00000497306 ENSG00000115290 HEK293_OSMI2_2hA HEK293_TMG_2hB GRB14 protein_coding processed_transcript 3.212515 3.071536 3.226169 0.269513 0.2311284 0.07063695 0.52403508 0.5652326 0.08970319 0.22746497 0.08970319 -2.5284339 0.14949167 0.1821333 0.02470000 -0.15743333 0.11633172 0.04386232   FALSE
ENST00000696453 ENSG00000115290 HEK293_OSMI2_2hA HEK293_TMG_2hB GRB14 protein_coding protein_coding 3.212515 3.071536 3.226169 0.269513 0.2311284 0.07063695 0.92197361 1.4802330 0.88744619 0.09694557 0.17975572 -0.7316405 0.29256250 0.4881333 0.26983333 -0.21830000 0.04386232 0.04386232 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115290 E001 0.0000000       2 164492417 164492811 395 -      
ENSG00000115290 E002 0.0000000       2 164492812 164492812 1 -      
ENSG00000115290 E003 0.4031496 0.0242959904 0.190390703 0.314252183 2 164492813 164492821 9 - 0.000 0.221 9.853
ENSG00000115290 E004 39.6480640 0.0183322667 0.908247310 0.945714403 2 164492822 164493182 361 - 1.592 1.612 0.070
ENSG00000115290 E005 26.9021184 0.0111142405 0.459749534 0.599845618 2 164494431 164494524 94 - 1.392 1.462 0.240
ENSG00000115290 E006 33.6887992 0.0008572315 0.066485646 0.137532553 2 164497008 164497095 88 - 1.464 1.574 0.375
ENSG00000115290 E007 27.8279346 0.0008269402 0.119845021 0.219764206 2 164497211 164497283 73 - 1.398 1.498 0.346
ENSG00000115290 E008 26.9009025 0.0009361259 0.276860563 0.416339125 2 164497374 164497490 117 - 1.403 1.475 0.246
ENSG00000115290 E009 17.8441348 0.0019438836 0.301549342 0.443372177 2 164502255 164502335 81 - 1.222 1.306 0.296
ENSG00000115290 E010 14.0268901 0.0015142169 0.360222176 0.504535820 2 164508455 164508550 96 - 1.119 1.202 0.297
ENSG00000115290 E011 1.9165636 0.0075481404 0.604577469 0.725055552 2 164508551 164508603 53 - 0.510 0.424 -0.434
ENSG00000115290 E012 1.5865661 0.0085573588 0.222323795 0.353174874 2 164508663 164508741 79 - 0.510 0.300 -1.171
ENSG00000115290 E013 14.3109067 0.0122845381 0.117960513 0.217009678 2 164508742 164508852 111 - 1.097 1.252 0.549
ENSG00000115290 E014 18.3386909 0.0012364556 0.831612503 0.894467261 2 164521980 164522117 138 - 1.291 1.276 -0.052
ENSG00000115290 E015 9.9328735 0.0184958511 0.849260873 0.906420403 2 164525004 164525041 38 - 1.051 1.026 -0.092
ENSG00000115290 E016 9.2581271 0.0021277785 0.904670179 0.943298997 2 164525042 164525078 37 - 0.998 1.012 0.052
ENSG00000115290 E017 19.5087811 0.0009540988 0.157369891 0.271604888 2 164527014 164527135 122 - 1.357 1.253 -0.363
ENSG00000115290 E018 0.6621732 0.1009709755 0.972276596 0.986703687 2 164539766 164539897 132 - 0.215 0.221 0.054
ENSG00000115290 E019 18.6556584 0.0013251698 0.005625455 0.017619084 2 164547660 164547816 157 - 1.386 1.174 -0.745
ENSG00000115290 E020 0.7717446 0.2308443981 0.810312059 0.879619463 2 164568315 164568521 207 - 0.292 0.219 -0.546
ENSG00000115290 E021 13.7655373 0.0014203929 0.022383139 0.056471901 2 164619687 164619819 133 - 1.254 1.052 -0.721
ENSG00000115290 E022 0.0000000       2 164619820 164619957 138 -      
ENSG00000115290 E023 6.3579045 0.0026840445 0.033323849 0.078434361 2 164621119 164621234 116 - 0.984 0.725 -1.003
ENSG00000115290 E024 7.6562041 0.0026088266 0.001276508 0.004898926 2 164621235 164621482 248 - 1.097 0.725 -1.418