ENSG00000115286

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000233627 ENSG00000115286 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFS7 protein_coding protein_coding 185.8964 368.6674 83.3588 20.52076 0.7751081 -2.144779 31.37950 70.35699 11.071565 3.041585 0.3732141 -2.666737 0.15161667 0.19113333 0.13276667 -0.05836667 5.579909e-07 1.831208e-07 FALSE  
ENST00000538929 ENSG00000115286 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFS7 protein_coding processed_transcript 185.8964 368.6674 83.3588 20.52076 0.7751081 -2.144779 128.27392 259.32148 57.069445 15.070279 0.8726921 -2.183754 0.67845417 0.70326667 0.68470000 -0.01856667 6.583709e-01 1.831208e-07 FALSE  
ENST00000546283 ENSG00000115286 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFS7 protein_coding protein_coding 185.8964 368.6674 83.3588 20.52076 0.7751081 -2.144779 12.42796 21.10491 7.166606 1.942466 0.4184305 -1.556889 0.07535417 0.05703333 0.08606667 0.02903333 5.431281e-03 1.831208e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115286 E001 0.4847352 2.355139e-01 8.097358e-02 1.610588e-01 19 1383495 1383526 32 + 0.393 0.059 -3.342
ENSG00000115286 E002 1.8413589 6.153260e-01 6.352386e-01 7.495910e-01 19 1383527 1383559 33 + 0.508 0.330 -0.967
ENSG00000115286 E003 3.1227266 1.318592e-01 6.260664e-01 7.420691e-01 19 1383560 1383608 49 + 0.393 0.518 0.645
ENSG00000115286 E004 16.2914043 3.784494e-02 6.800566e-01 7.840477e-01 19 1383708 1383874 167 + 1.023 1.095 0.262
ENSG00000115286 E005 13.4016508 1.351614e-02 9.311647e-01 9.606484e-01 19 1383875 1383889 15 + 0.991 1.007 0.057
ENSG00000115286 E006 50.1450054 4.710504e-04 2.254477e-01 3.569461e-01 19 1383890 1383899 10 + 1.609 1.534 -0.255
ENSG00000115286 E007 52.2632323 4.645552e-04 8.250344e-02 1.634581e-01 19 1383900 1383903 4 + 1.654 1.549 -0.358
ENSG00000115286 E008 58.2257618 4.290013e-04 3.002116e-01 4.418660e-01 19 1383904 1383906 3 + 1.661 1.602 -0.200
ENSG00000115286 E009 293.9111396 2.966649e-04 2.722941e-02 6.645534e-02 19 1383907 1383917 11 + 2.355 2.297 -0.193
ENSG00000115286 E010 404.7082980 1.492086e-04 1.666278e-08 1.971221e-07 19 1383918 1383921 4 + 2.551 2.425 -0.420
ENSG00000115286 E011 1141.4601230 8.302822e-04 9.217523e-01 9.546217e-01 19 1383922 1383937 16 + 2.891 2.897 0.022
ENSG00000115286 E012 1181.9739755 5.920009e-04 9.698273e-01 9.851152e-01 19 1383938 1383942 5 + 2.905 2.912 0.025
ENSG00000115286 E013 8.5971118 2.005423e-03 1.431674e-07 1.411608e-06 19 1383943 1384050 108 + 1.287 0.690 -2.235
ENSG00000115286 E014 14.9231569 1.456404e-03 8.914914e-08 9.135629e-07 19 1384051 1384156 106 + 1.438 0.937 -1.788
ENSG00000115286 E015 6.1163923 3.093231e-03 9.005558e-05 4.752566e-04 19 1384639 1384771 133 + 1.105 0.590 -2.023
ENSG00000115286 E016 12.2305546 1.414725e-03 3.602539e-04 1.619932e-03 19 1386518 1386627 110 + 1.270 0.891 -1.376
ENSG00000115286 E017 7.4397302 1.202725e-02 5.156171e-03 1.635367e-02 19 1386628 1386639 12 + 1.080 0.704 -1.440
ENSG00000115286 E018 3.9591951 1.109851e-01 1.552563e-02 4.168428e-02 19 1387739 1387803 65 + 0.957 0.474 -2.023
ENSG00000115286 E019 10.4638093 5.543819e-02 2.049773e-01 3.323748e-01 19 1387804 1387810 7 + 1.080 0.896 -0.680
ENSG00000115286 E020 1614.9334899 6.414700e-04 3.574910e-02 8.309890e-02 19 1387811 1387847 37 + 3.009 3.053 0.146
ENSG00000115286 E021 1.3629428 1.040541e-02 7.884176e-03 2.348776e-02 19 1388000 1388024 25 + 0.669 0.198 -2.671
ENSG00000115286 E022 6.7356301 2.500524e-03 9.013123e-06 6.055212e-05 19 1388025 1388304 280 + 1.174 0.621 -2.135
ENSG00000115286 E023 2177.3213812 2.828279e-04 4.834700e-02 1.062404e-01 19 1388525 1388593 69 + 3.148 3.181 0.108
ENSG00000115286 E024 35.8601797 1.541728e-03 8.994584e-06 6.044472e-05 19 1388594 1388742 149 + 1.661 1.355 -1.049
ENSG00000115286 E025 43.4382783 2.116667e-03 4.444273e-04 1.945276e-03 19 1388743 1388832 90 + 1.681 1.449 -0.791
ENSG00000115286 E026 1514.1852965 1.095499e-04 7.471152e-01 8.347019e-01 19 1388833 1388839 7 + 3.017 3.019 0.006
ENSG00000115286 E027 2851.3081035 5.657221e-05 2.544365e-01 3.911216e-01 19 1388840 1388938 99 + 3.279 3.295 0.055
ENSG00000115286 E028 45.7015609 4.932053e-04 5.578354e-20 3.532094e-18 19 1388939 1390870 1932 + 1.908 1.395 -1.748
ENSG00000115286 E029 3293.5869050 2.465755e-04 6.543541e-02 1.357681e-01 19 1390871 1391050 180 + 3.333 3.361 0.091
ENSG00000115286 E030 27.6236829 1.419577e-03 3.365918e-02 7.907627e-02 19 1391051 1391118 68 + 1.450 1.279 -0.591
ENSG00000115286 E031 1625.6548953 7.862577e-04 2.046628e-01 3.319726e-01 19 1391119 1391165 47 + 3.024 3.056 0.104
ENSG00000115286 E032 52.4379511 1.184399e-02 7.994754e-09 1.003832e-07 19 1391842 1393241 1400 + 1.900 1.476 -1.441
ENSG00000115286 E033 1946.7228440 9.244536e-04 3.940388e-02 8.992611e-02 19 1393242 1393330 89 + 3.091 3.136 0.150
ENSG00000115286 E034 406.3820452 9.462532e-04 4.110161e-30 7.014934e-28 19 1393331 1394417 1087 + 2.680 2.398 -0.940
ENSG00000115286 E035 412.8380956 1.583570e-03 6.807279e-03 2.072242e-02 19 1394418 1395390 973 + 2.520 2.446 -0.248
ENSG00000115286 E036 1261.4082285 1.182440e-03 6.016721e-08 6.377138e-07 19 1395391 1396978 1588 + 2.831 2.957 0.420