ENSG00000115282

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000233623 ENSG00000115282 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC31 protein_coding protein_coding 15.94529 18.9 9.730873 1.550758 0.5115249 -0.9570261 4.076515 5.3532451 2.1126371 0.42434193 0.2103562 -1.3372485 0.2546083 0.29016667 0.22023333 -0.06993333 5.761905e-01 1.623536e-05 FALSE  
ENST00000410003 ENSG00000115282 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC31 protein_coding protein_coding 15.94529 18.9 9.730873 1.550758 0.5115249 -0.9570261 1.637158 1.0742043 1.3084749 0.25822591 0.1215837 0.2822335 0.1045167 0.05540000 0.13510000 0.07970000 2.694789e-03 1.623536e-05 FALSE  
ENST00000414247 ENSG00000115282 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC31 protein_coding protein_coding 15.94529 18.9 9.730873 1.550758 0.5115249 -0.9570261 0.532590 1.2000015 0.1470971 0.08218578 0.0903484 -2.9452804 0.0273875 0.06500000 0.01423333 -0.05076667 6.508690e-02 1.623536e-05 FALSE  
ENST00000424122 ENSG00000115282 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC31 protein_coding nonsense_mediated_decay 15.94529 18.9 9.730873 1.550758 0.5115249 -0.9570261 2.551826 2.6274559 1.6291004 1.22793638 0.9113937 -0.6862427 0.1504875 0.13496667 0.17370000 0.03873333 1.000000e+00 1.623536e-05 FALSE  
ENST00000459957 ENSG00000115282 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC31 protein_coding retained_intron 15.94529 18.9 9.730873 1.550758 0.5115249 -0.9570261 1.097447 0.4986928 0.9035292 0.11008666 0.1192440 0.8446563 0.0744500 0.02583333 0.09240000 0.06656667 1.623536e-05 1.623536e-05 FALSE  
MSTRG.18706.8 ENSG00000115282 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC31 protein_coding   15.94529 18.9 9.730873 1.550758 0.5115249 -0.9570261 2.330971 4.7975333 1.2902534 1.12147157 0.7623180 -1.8865040 0.1529000 0.25413333 0.12896667 -0.12516667 6.451044e-01 1.623536e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115282 E001 1.0329558 0.0121989077 3.941762e-01 0.5380635169 2 74483073 74483080 8 + 0.166 0.331 1.291
ENSG00000115282 E002 0.8512514 0.0136968632 5.496792e-01 0.6793780707 2 74483081 74483081 1 + 0.166 0.282 0.976
ENSG00000115282 E003 3.9019337 0.0042096330 5.286953e-01 0.6615964107 2 74483082 74483086 5 + 0.578 0.688 0.479
ENSG00000115282 E004 4.3448241 0.0036937328 3.737506e-01 0.5181574468 2 74483087 74483088 2 + 0.578 0.727 0.640
ENSG00000115282 E005 8.4359126 0.0020345958 8.148695e-01 0.8827053923 2 74483089 74483099 11 + 0.901 0.943 0.158
ENSG00000115282 E006 11.4576430 0.0015515678 1.247311e-01 0.2267573452 2 74483100 74483100 1 + 1.146 1.006 -0.508
ENSG00000115282 E007 20.0011786 0.0009188720 1.243281e-01 0.2261658892 2 74483101 74483101 1 + 1.349 1.242 -0.377
ENSG00000115282 E008 23.0455182 0.0008525210 1.957937e-01 0.3209640956 2 74483102 74483104 3 + 1.392 1.310 -0.286
ENSG00000115282 E009 32.8713414 0.0006549360 1.986099e-01 0.3244492383 2 74483105 74483135 31 + 1.531 1.464 -0.230
ENSG00000115282 E010 51.1960792 0.0005884248 2.085430e-01 0.3367327470 2 74483322 74483410 89 + 1.709 1.658 -0.171
ENSG00000115282 E011 8.6291830 0.0021969872 4.703684e-01 0.6095901309 2 74483411 74483563 153 + 0.875 0.975 0.378
ENSG00000115282 E012 0.9566832 0.0148292884 9.519770e-01 0.9739444525 2 74483564 74483705 142 + 0.285 0.281 -0.026
ENSG00000115282 E013 51.1454512 0.0056280731 8.340702e-01 0.8960903398 2 74490025 74490127 103 + 1.672 1.674 0.008
ENSG00000115282 E014 5.7709952 0.0029256596 7.977806e-03 0.0237211829 2 74490128 74490243 116 + 0.992 0.668 -1.271
ENSG00000115282 E015 129.0054636 0.0024660700 8.755874e-02 0.1714318048 2 74490244 74490473 230 + 2.098 2.050 -0.163
ENSG00000115282 E016 6.3275978 0.0687598396 2.175562e-02 0.0551681582 2 74490474 74490655 182 + 1.050 0.673 -1.461
ENSG00000115282 E017 97.6614999 0.0005966693 1.596790e-01 0.2746917626 2 74490656 74490739 84 + 1.970 1.931 -0.130
ENSG00000115282 E018 9.4523916 0.0020425946 2.511308e-03 0.0087979826 2 74490740 74491127 388 + 1.174 0.869 -1.123
ENSG00000115282 E019 86.8896480 0.0003801550 4.830212e-01 0.6211102044 2 74491128 74491184 57 + 1.902 1.890 -0.043
ENSG00000115282 E020 85.7577383 0.0004105367 6.789864e-01 0.7832951351 2 74491295 74491375 81 + 1.890 1.888 -0.005
ENSG00000115282 E021 77.5973446 0.0076608301 4.708849e-01 0.6100674554 2 74491481 74491569 89 + 1.800 1.864 0.216
ENSG00000115282 E022 48.4476968 0.0089054419 5.437086e-01 0.6742685870 2 74491570 74491583 14 + 1.658 1.638 -0.069
ENSG00000115282 E023 57.7277951 0.0119635931 8.198228e-01 0.8862631133 2 74491584 74491628 45 + 1.688 1.731 0.145
ENSG00000115282 E024 56.0822596 0.0006651535 1.766314e-01 0.2968673464 2 74491629 74491666 38 + 1.640 1.727 0.294
ENSG00000115282 E025 21.4080229 0.0008590270 6.032234e-01 0.7240583969 2 74491667 74491672 6 + 1.321 1.295 -0.092
ENSG00000115282 E026 2.8527090 0.0185463277 9.185649e-02 0.1780158115 2 74491673 74491943 271 + 0.714 0.452 -1.191
ENSG00000115282 E027 7.5316713 0.0025187968 3.757612e-01 0.5201776234 2 74491944 74492003 60 + 0.949 0.855 -0.355
ENSG00000115282 E028 57.7942872 0.0004617728 9.531335e-01 0.9746907153 2 74492004 74492055 52 + 1.712 1.725 0.042
ENSG00000115282 E029 5.8086478 0.0031396545 9.023251e-04 0.0036217944 2 74492056 74492138 83 + 1.031 0.623 -1.607
ENSG00000115282 E030 71.6390042 0.0016670256 2.415245e-01 0.3759775161 2 74492139 74492229 91 + 1.837 1.799 -0.130
ENSG00000115282 E031 13.3057449 0.0111798529 1.382851e-06 0.0000111380 2 74492230 74492303 74 + 1.392 0.919 -1.697
ENSG00000115282 E032 91.0892519 0.0003989711 6.141849e-01 0.7327309564 2 74492304 74492445 142 + 1.920 1.915 -0.014
ENSG00000115282 E033 15.4571376 0.0011611255 4.160033e-04 0.0018358355 2 74492446 74492645 200 + 1.358 1.069 -1.023
ENSG00000115282 E034 53.0596074 0.0030088612 4.962540e-02 0.1084996136 2 74492646 74492675 30 + 1.592 1.725 0.451
ENSG00000115282 E035 73.5551386 0.0008110521 4.368284e-01 0.5788577585 2 74492676 74492747 72 + 1.791 1.842 0.172
ENSG00000115282 E036 18.2188148 0.0012234496 1.652174e-01 0.2819662352 2 74492748 74492921 174 + 1.302 1.200 -0.357
ENSG00000115282 E037 36.3860867 0.0103851648 6.430720e-01 0.7556974993 2 74492922 74492924 3 + 1.548 1.528 -0.071
ENSG00000115282 E038 61.6414120 0.0111654907 7.446915e-01 0.8329372462 2 74492925 74492966 42 + 1.728 1.766 0.129
ENSG00000115282 E039 625.3381149 0.0023944761 4.292119e-05 0.0002456806 2 74492967 74494559 1593 + 2.674 2.782 0.358