ENSG00000115275

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000448666 ENSG00000115275 HEK293_OSMI2_2hA HEK293_TMG_2hB MOGS protein_coding protein_coding 63.95471 84.70487 38.14013 4.649222 1.735602 -1.150927 37.309762 42.224974 24.4779796 4.357972 0.5112041 -0.7863644 0.5910208 0.49830000 0.64356667 0.14526667 0.089583215 1.55674e-06 FALSE  
ENST00000452063 ENSG00000115275 HEK293_OSMI2_2hA HEK293_TMG_2hB MOGS protein_coding protein_coding 63.95471 84.70487 38.14013 4.649222 1.735602 -1.150927 7.154505 9.943236 2.4513558 1.346768 0.1633236 -2.0157124 0.1065625 0.11643333 0.06416667 -0.05226667 0.002186489 1.55674e-06 FALSE  
ENST00000462189 ENSG00000115275 HEK293_OSMI2_2hA HEK293_TMG_2hB MOGS protein_coding retained_intron 63.95471 84.70487 38.14013 4.649222 1.735602 -1.150927 6.082937 6.143760 4.1656530 0.510631 0.5082013 -0.5594663 0.1002250 0.07233333 0.10906667 0.03673333 0.080928848 1.55674e-06 FALSE  
ENST00000462443 ENSG00000115275 HEK293_OSMI2_2hA HEK293_TMG_2hB MOGS protein_coding protein_coding 63.95471 84.70487 38.14013 4.649222 1.735602 -1.150927 4.448392 16.272769 0.6412437 3.436595 0.3229754 -4.6440048 0.0589625 0.19486667 0.01650000 -0.17836667 0.058832895 1.55674e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115275 E001 0.7780993 0.0475226712 6.627787e-01 7.710109e-01 2 74461057 74461068 12 - 0.177 0.264 0.729
ENSG00000115275 E002 3.9885115 0.0885956898 1.075643e-02 3.058158e-02 2 74461069 74461069 1 - 0.177 0.756 3.222
ENSG00000115275 E003 55.9618785 0.0033693395 7.214414e-01 8.158235e-01 2 74461070 74461101 32 - 1.680 1.707 0.092
ENSG00000115275 E004 63.5432539 0.0027412855 4.643340e-01 6.040755e-01 2 74461102 74461105 4 - 1.719 1.766 0.157
ENSG00000115275 E005 89.9649216 0.0160792418 5.917152e-01 7.144217e-01 2 74461106 74461117 12 - 1.867 1.915 0.160
ENSG00000115275 E006 106.8210656 0.0175366693 4.652099e-01 6.049325e-01 2 74461118 74461119 2 - 1.931 1.991 0.201
ENSG00000115275 E007 117.6002600 0.0136787327 4.310654e-01 5.736567e-01 2 74461120 74461125 6 - 1.972 2.032 0.201
ENSG00000115275 E008 168.9967784 0.0084218680 2.450602e-01 3.800917e-01 2 74461126 74461169 44 - 2.119 2.191 0.242
ENSG00000115275 E009 178.2258618 0.0088854576 1.379180e-01 2.451852e-01 2 74461170 74461178 9 - 2.127 2.218 0.305
ENSG00000115275 E010 173.0919615 0.0107067840 9.943330e-02 1.896209e-01 2 74461179 74461183 5 - 2.102 2.209 0.359
ENSG00000115275 E011 197.7224568 0.0078531158 1.705321e-01 2.888456e-01 2 74461184 74461222 39 - 2.181 2.260 0.265
ENSG00000115275 E012 190.0899613 0.0061966038 1.571766e-01 2.713381e-01 2 74461223 74461257 35 - 2.166 2.243 0.256
ENSG00000115275 E013 137.8077019 0.0058330136 5.708795e-01 6.973011e-01 2 74461258 74461274 17 - 2.058 2.094 0.120
ENSG00000115275 E014 115.0271765 0.0031850399 7.827606e-01 8.605297e-01 2 74461275 74461277 3 - 1.992 2.011 0.064
ENSG00000115275 E015 469.2905091 0.0008739309 1.931930e-09 2.713511e-08 2 74461278 74461369 92 - 2.498 2.647 0.496
ENSG00000115275 E016 979.5001474 0.0013988459 8.289242e-07 7.005898e-06 2 74461370 74461639 270 - 2.845 2.958 0.378
ENSG00000115275 E017 841.1045555 0.0005750695 1.373192e-14 4.434829e-13 2 74461640 74461933 294 - 2.752 2.897 0.481
ENSG00000115275 E018 796.2822919 0.0010247735 1.844004e-03 6.740002e-03 2 74461934 74462180 247 - 2.788 2.858 0.234
ENSG00000115275 E019 512.4134389 0.0009934338 1.606474e-01 2.759694e-01 2 74462181 74462278 98 - 2.621 2.660 0.129
ENSG00000115275 E020 700.4135370 0.0004560719 4.488556e-01 5.900912e-01 2 74462279 74462494 216 - 2.771 2.790 0.062
ENSG00000115275 E021 836.7053583 0.0002584360 8.723492e-01 9.219077e-01 2 74462495 74462773 279 - 2.856 2.864 0.025
ENSG00000115275 E022 274.7759770 0.0002098677 9.119344e-01 9.481389e-01 2 74462774 74462793 20 - 2.372 2.380 0.026
ENSG00000115275 E023 315.9969749 0.0001965033 4.575780e-01 5.978975e-01 2 74462794 74462834 41 - 2.448 2.436 -0.040
ENSG00000115275 E024 490.1604012 0.0004109490 3.589883e-03 1.198105e-02 2 74462835 74462960 126 - 2.668 2.616 -0.172
ENSG00000115275 E025 304.5483701 0.0005756829 1.042793e-03 4.106809e-03 2 74462961 74462996 36 - 2.479 2.403 -0.251
ENSG00000115275 E026 247.6966375 0.0002151492 8.416163e-04 3.407529e-03 2 74462997 74463012 16 - 2.391 2.312 -0.263
ENSG00000115275 E027 8.7089141 0.0293160038 4.325796e-03 1.405724e-02 2 74463013 74463189 177 - 1.179 0.809 -1.373
ENSG00000115275 E028 303.4594635 0.0002971730 1.868884e-04 9.075063e-04 2 74463190 74463219 30 - 2.481 2.399 -0.273
ENSG00000115275 E029 462.0687505 0.0006656387 6.905059e-07 5.936928e-06 2 74463220 74463331 112 - 2.676 2.576 -0.333
ENSG00000115275 E030 299.3378016 0.0001804073 1.279724e-04 6.499379e-04 2 74463332 74463379 48 - 2.476 2.394 -0.274
ENSG00000115275 E031 212.7338373 0.0002644091 1.479184e-04 7.380612e-04 2 74463380 74463386 7 - 2.339 2.241 -0.326
ENSG00000115275 E032 26.6789495 0.0007783412 5.344033e-05 2.989379e-04 2 74463387 74463646 260 - 1.565 1.290 -0.950
ENSG00000115275 E033 12.2681795 0.0112435573 4.205951e-01 5.637994e-01 2 74464417 74464495 79 - 1.117 1.032 -0.309
ENSG00000115275 E034 464.1934270 0.0018898762 1.184253e-03 4.587624e-03 2 74464496 74464665 170 - 2.666 2.585 -0.270
ENSG00000115275 E035 258.4912765 0.0015662518 7.449145e-06 5.095202e-05 2 74464666 74464722 57 - 2.446 2.317 -0.430
ENSG00000115275 E036 22.9226051 0.0008075839 1.818415e-05 1.139009e-04 2 74464723 74464895 173 - 1.528 1.219 -1.073
ENSG00000115275 E037 271.9548726 0.0038277594 5.946591e-04 2.513754e-03 2 74464896 74464987 92 - 2.462 2.340 -0.408
ENSG00000115275 E038 181.3463155 0.0106322009 1.929091e-02 4.996658e-02 2 74464988 74465081 94 - 2.288 2.164 -0.414
ENSG00000115275 E039 260.4873351 0.0088959279 5.219641e-03 1.652841e-02 2 74465082 74465313 232 - 2.452 2.319 -0.443
ENSG00000115275 E040 153.2016496 0.0090122658 3.398167e-03 1.143306e-02 2 74465314 74465410 97 - 2.235 2.082 -0.509