ENSG00000115232

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000233573 ENSG00000115232 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA4 protein_coding protein_coding 0.5295137 0.3301335 0.8647849 0.06775199 0.0126561 1.362827 0.093228971 0.00000000 0.28383375 0.00000000 0.05642616 4.8769282 0.133425000 0.00000000 0.32810000 0.32810000 0.003232941 0.003232941 FALSE TRUE
ENST00000339307 ENSG00000115232 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA4 protein_coding protein_coding 0.5295137 0.3301335 0.8647849 0.06775199 0.0126561 1.362827 0.024967103 0.04383353 0.01474207 0.02409620 0.01474207 -1.1215386 0.043241667 0.10930000 0.01663333 -0.09266667 0.247972114 0.003232941 TRUE TRUE
ENST00000397033 ENSG00000115232 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA4 protein_coding protein_coding 0.5295137 0.3301335 0.8647849 0.06775199 0.0126561 1.362827 0.272396561 0.20582744 0.38269999 0.01316934 0.02708578 0.8635493 0.615479167 0.68920000 0.44210000 -0.24710000 0.367889245 0.003232941 FALSE TRUE
ENST00000465522 ENSG00000115232 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA4 protein_coding retained_intron 0.5295137 0.3301335 0.8647849 0.06775199 0.0126561 1.362827 0.038856526 0.01119748 0.08617998 0.01119748 0.06413644 2.1818438 0.065416667 0.02946667 0.09910000 0.06963333 0.807649102 0.003232941 FALSE TRUE
ENST00000476824 ENSG00000115232 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA4 protein_coding retained_intron 0.5295137 0.3301335 0.8647849 0.06775199 0.0126561 1.362827 0.075003017 0.00000000 0.09732914 0.00000000 0.04910238 3.4239699 0.085420833 0.00000000 0.11410000 0.11410000 0.478440076 0.003232941 FALSE TRUE
ENST00000484404 ENSG00000115232 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA4 protein_coding retained_intron 0.5295137 0.3301335 0.8647849 0.06775199 0.0126561 1.362827 0.002758781 0.02207025 0.00000000 0.02207025 0.00000000 -1.6812354 0.007258333 0.05806667 0.00000000 -0.05806667 0.371317591 0.003232941 FALSE TRUE
ENST00000490435 ENSG00000115232 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA4 protein_coding retained_intron 0.5295137 0.3301335 0.8647849 0.06775199 0.0126561 1.362827 0.010872525 0.03173248 0.00000000 0.03173248 0.00000000 -2.0611706 0.027308333 0.07660000 0.00000000 -0.07660000 0.480892468 0.003232941 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115232 E001 0.0000000       2 181457202 181457206 5 +      
ENSG00000115232 E002 0.4481018 0.034139709 0.2254210842 0.356917013 2 181457207 181457385 179 + 0.087 0.290 2.102
ENSG00000115232 E003 0.5996172 0.181962377 0.5202164951 0.654205584 2 181457386 181457403 18 + 0.160 0.287 1.077
ENSG00000115232 E004 0.5996172 0.181962377 0.5202164951 0.654205584 2 181457404 181457427 24 + 0.160 0.287 1.077
ENSG00000115232 E005 2.9591770 0.006226282 0.0857315844 0.168559924 2 181457428 181457712 285 + 0.678 0.386 -1.396
ENSG00000115232 E006 2.4380224 0.030465700 0.0878671773 0.171881144 2 181457713 181457851 139 + 0.613 0.291 -1.698
ENSG00000115232 E007 1.2587586 0.011314914 0.2109925785 0.339712325 2 181458196 181458240 45 + 0.407 0.170 -1.698
ENSG00000115232 E008 1.6274528 0.010287510 0.4139759047 0.557398265 2 181458241 181458317 77 + 0.443 0.292 -0.890
ENSG00000115232 E009 0.0000000       2 181458318 181459391 1074 +      
ENSG00000115232 E010 2.5495920 0.006337964 0.3145084887 0.457220501 2 181474960 181475066 107 + 0.476 0.638 0.745
ENSG00000115232 E011 0.1482932 0.041159753 0.2249307806   2 181475067 181475158 92 + 0.000 0.169 11.833
ENSG00000115232 E012 3.8218793 0.062618415 0.5108142759 0.645970750 2 181475159 181475288 130 + 0.637 0.755 0.492
ENSG00000115232 E013 0.0000000       2 181475289 181475290 2 +      
ENSG00000115232 E014 0.4428904 0.571580864 0.1436099136 0.252923428 2 181475820 181476218 399 + 0.000 0.305 12.262
ENSG00000115232 E015 3.2557619 0.004805333 0.7558797444 0.841091252 2 181478757 181478824 68 + 0.636 0.587 -0.214
ENSG00000115232 E016 0.0000000       2 181478825 181479716 892 +      
ENSG00000115232 E017 3.4040802 0.043248953 0.4272610267 0.570091629 2 181480137 181480266 130 + 0.589 0.721 0.563
ENSG00000115232 E018 2.3896707 0.103898930 0.3307342637 0.474319123 2 181481598 181481683 86 + 0.443 0.636 0.908
ENSG00000115232 E019 1.6951184 0.008783761 0.7452588228 0.833360179 2 181482360 181482422 63 + 0.407 0.464 0.300
ENSG00000115232 E020 4.0263607 0.010449854 0.7593377923 0.843709567 2 181482514 181482651 138 + 0.678 0.724 0.188
ENSG00000115232 E021 5.3904363 0.003729970 0.7507700225 0.837367922 2 181485881 181485992 112 + 0.785 0.828 0.168
ENSG00000115232 E022 0.8804994 0.260820355 0.5221010287 0.655961546 2 181485993 181486309 317 + 0.323 0.168 -1.230
ENSG00000115232 E023 0.0000000       2 181493034 181493324 291 +      
ENSG00000115232 E024 3.6726161 0.008019529 0.9027810443 0.942101798 2 181493325 181493419 95 + 0.658 0.638 -0.084
ENSG00000115232 E025 3.8041729 0.004557949 0.4729308826 0.611956181 2 181494722 181494812 91 + 0.698 0.588 -0.476
ENSG00000115232 E026 1.3297351 0.009906444 0.0174278985 0.045886385 2 181495371 181495416 46 + 0.476 0.000 -13.676
ENSG00000115232 E027 1.9240417 0.007324298 0.0368762136 0.085231536 2 181495783 181495832 50 + 0.563 0.170 -2.477
ENSG00000115232 E028 3.6028026 0.004883603 0.0282355934 0.068479198 2 181495833 181495937 105 + 0.752 0.386 -1.700
ENSG00000115232 E029 0.2214452 0.041311299 0.2218656791   2 181498281 181498571 291 + 0.000 0.170 11.838
ENSG00000115232 E030 0.0000000       2 181498572 181498622 51 +      
ENSG00000115232 E031 4.3308416 0.004884060 0.0339610719 0.079677802 2 181498623 181498777 155 + 0.801 0.464 -1.476
ENSG00000115232 E032 4.6543827 0.003507481 0.1499559974 0.261614457 2 181509658 181509805 148 + 0.801 0.587 -0.892
ENSG00000115232 E033 2.2475803 0.013007554 0.3906508643 0.534621356 2 181509806 181509807 2 + 0.443 0.587 0.693
ENSG00000115232 E034 2.8376205 0.124963508 0.5628008175 0.690348839 2 181511699 181511771 73 + 0.536 0.635 0.447
ENSG00000115232 E035 0.9597786 0.253727431 0.4184341191 0.561696393 2 181511772 181511775 4 + 0.221 0.384 1.096
ENSG00000115232 E036 2.9023561 0.108620795 0.4447458427 0.586310606 2 181522191 181522341 151 + 0.635 0.463 -0.800
ENSG00000115232 E037 0.0000000       2 181523335 181523436 102 +      
ENSG00000115232 E038 2.2476846 0.010414669 0.0191485037 0.049661541 2 181523437 181523532 96 + 0.613 0.170 -2.699
ENSG00000115232 E039 1.5092494 0.009123582 0.1061957522 0.199917192 2 181524171 181524250 80 + 0.476 0.170 -2.061
ENSG00000115232 E040 0.0000000       2 181524251 181524365 115 +      
ENSG00000115232 E041 1.9499643 0.008250520 0.1795007291 0.300508785 2 181525202 181525291 90 + 0.536 0.291 -1.352
ENSG00000115232 E042 2.6561462 0.012322482 0.1484829661 0.259611201 2 181527297 181527387 91 + 0.636 0.386 -1.217
ENSG00000115232 E043 0.0000000       2 181527388 181527450 63 +      
ENSG00000115232 E044 2.9087108 0.008671088 0.9830394261 0.993463823 2 181529541 181529648 108 + 0.589 0.587 -0.009
ENSG00000115232 E045 2.0574699 0.008013664 0.6082620574 0.728046636 2 181530524 181530649 126 + 0.443 0.530 0.430
ENSG00000115232 E046 2.9644716 0.010024402 0.8694205702 0.920059875 2 181531657 181531776 120 + 0.564 0.588 0.110
ENSG00000115232 E047 3.8773354 0.062884951 0.4680884900 0.607512281 2 181534272 181534370 99 + 0.613 0.731 0.496
ENSG00000115232 E048 4.4779848 0.013912550 0.5442455250 0.674732392 2 181534816 181534935 120 + 0.678 0.763 0.348
ENSG00000115232 E049 26.6588578 0.001088813 0.0002317162 0.001098713 2 181535432 181538940 3509 + 1.335 1.555 0.758