ENSG00000115216

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379852 ENSG00000115216 HEK293_OSMI2_2hA HEK293_TMG_2hB NRBP1 protein_coding protein_coding 51.63949 56.47116 50.02032 8.098984 0.6481689 -0.1749672 37.056795 44.055100 34.441739 6.79816841 1.13056802 -0.3550597 0.7140292 0.77856667 0.68820000 -0.09036667 0.020695747 0.0003318079 FALSE  
ENST00000460499 ENSG00000115216 HEK293_OSMI2_2hA HEK293_TMG_2hB NRBP1 protein_coding retained_intron 51.63949 56.47116 50.02032 8.098984 0.6481689 -0.1749672 2.597642 1.381086 2.460043 0.09370776 0.04892196 0.8283243 0.0515000 0.02546667 0.04916667 0.02370000 0.003620345 0.0003318079 FALSE  
MSTRG.18127.2 ENSG00000115216 HEK293_OSMI2_2hA HEK293_TMG_2hB NRBP1 protein_coding   51.63949 56.47116 50.02032 8.098984 0.6481689 -0.1749672 8.989325 9.449096 9.908969 1.46545005 0.85644816 0.0684878 0.1745625 0.16760000 0.19853333 0.03093333 0.637153172 0.0003318079 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115216 E001 0.1515154 0.0434145022 3.750877e-01   2 27427790 27428182 393 + 0.139 0.000 -9.699
ENSG00000115216 E002 0.0000000       2 27428250 27428317 68 +      
ENSG00000115216 E003 7.3175073 0.0029461481 1.833561e-02 4.786652e-02 2 27428318 27428630 313 + 1.062 0.802 -0.978
ENSG00000115216 E004 48.9098129 0.0016918563 3.829534e-01 5.271016e-01 2 27428631 27428652 22 + 1.714 1.676 -0.130
ENSG00000115216 E005 195.3561083 0.0069289222 4.429133e-01 5.844642e-01 2 27428653 27428731 79 + 2.306 2.270 -0.122
ENSG00000115216 E006 1.0361649 0.0183098773 6.607827e-01 7.693976e-01 2 27429183 27429366 184 + 0.244 0.328 0.584
ENSG00000115216 E007 0.6266857 0.0180269204 7.536197e-01 8.394935e-01 2 27431677 27431991 315 + 0.244 0.194 -0.418
ENSG00000115216 E008 151.9269509 0.0076103551 2.227798e-01 3.536916e-01 2 27433249 27433253 5 + 2.213 2.151 -0.209
ENSG00000115216 E009 527.7446223 0.0020642973 1.445012e-03 5.456511e-03 2 27433254 27433483 230 + 2.762 2.683 -0.262
ENSG00000115216 E010 456.2390530 0.0011628348 1.732439e-05 1.089949e-04 2 27433673 27433795 123 + 2.708 2.616 -0.304
ENSG00000115216 E011 326.5115102 0.0052328090 5.253910e-02 1.136814e-01 2 27433989 27434044 56 + 2.551 2.475 -0.253
ENSG00000115216 E012 277.9484810 0.0003552437 7.412598e-05 3.999130e-04 2 27434045 27434090 46 + 2.488 2.409 -0.263
ENSG00000115216 E013 380.6785448 0.0004244165 2.404861e-03 8.476320e-03 2 27434471 27434560 90 + 2.608 2.556 -0.175
ENSG00000115216 E014 279.2501231 0.0001950682 5.622173e-02 1.200956e-01 2 27434722 27434762 41 + 2.463 2.433 -0.100
ENSG00000115216 E015 20.0485483 0.0099916111 1.648017e-06 1.305343e-05 2 27434763 27435132 370 + 1.523 1.098 -1.488
ENSG00000115216 E016 410.7786798 0.0011333929 2.770350e-02 6.742824e-02 2 27435133 27435227 95 + 2.635 2.589 -0.154
ENSG00000115216 E017 11.4986356 0.0242960216 1.963112e-01 3.216037e-01 2 27435582 27435722 141 + 1.173 1.014 -0.575
ENSG00000115216 E018 5.4992836 0.0924672006 8.107239e-01 8.799354e-01 2 27435723 27435746 24 + 0.770 0.809 0.155
ENSG00000115216 E019 57.1021395 0.0005051617 4.090182e-15 1.425242e-13 2 27435747 27436752 1006 + 1.938 1.582 -1.206
ENSG00000115216 E020 427.1724592 0.0001286445 1.745090e-03 6.424696e-03 2 27436753 27436836 84 + 2.655 2.612 -0.143
ENSG00000115216 E021 341.4297193 0.0001743459 6.626721e-03 2.025512e-02 2 27437047 27437105 59 + 2.557 2.516 -0.139
ENSG00000115216 E022 413.4752962 0.0001494195 9.913168e-01 9.986481e-01 2 27437262 27437360 99 + 2.608 2.619 0.037
ENSG00000115216 E023 475.0632934 0.0003469348 3.077795e-01 4.500212e-01 2 27439766 27439898 133 + 2.656 2.683 0.091
ENSG00000115216 E024 2.8400261 0.0053490406 1.120145e-02 3.164923e-02 2 27440315 27440402 88 + 0.770 0.382 -1.795
ENSG00000115216 E025 461.3024246 0.0001433363 1.261048e-01 2.287301e-01 2 27440403 27440508 106 + 2.639 2.676 0.125
ENSG00000115216 E026 4.5629504 0.0037572913 7.628186e-01 8.463318e-01 2 27440509 27440651 143 + 0.711 0.762 0.210
ENSG00000115216 E027 343.7259072 0.0007432304 8.454637e-03 2.492229e-02 2 27440652 27440702 51 + 2.489 2.559 0.234
ENSG00000115216 E028 523.4988625 0.0025292101 4.380002e-02 9.802344e-02 2 27440805 27440925 121 + 2.673 2.734 0.204
ENSG00000115216 E029 272.2971785 0.0003077334 5.429117e-02 1.167576e-01 2 27440926 27440940 15 + 2.398 2.453 0.184
ENSG00000115216 E030 373.1413918 0.0013953136 1.751578e-02 4.607422e-02 2 27441127 27441180 54 + 2.523 2.594 0.235
ENSG00000115216 E031 376.9831089 0.0013031938 2.343735e-03 8.288010e-03 2 27441267 27441330 64 + 2.517 2.604 0.290
ENSG00000115216 E032 10.1004213 0.0247934004 4.616154e-01 6.015449e-01 2 27441331 27441501 171 + 1.090 0.999 -0.331
ENSG00000115216 E033 331.8420952 0.0001946835 6.974734e-08 7.300234e-07 2 27441567 27441622 56 + 2.441 2.563 0.409
ENSG00000115216 E034 770.4274660 0.0036185379 9.263829e-09 1.149466e-07 2 27441708 27442365 658 + 2.760 2.937 0.589