ENSG00000115211

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347454 ENSG00000115211 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B4 protein_coding protein_coding 56.03004 78.85538 44.6422 6.93105 0.5552056 -0.8206608 30.97791 49.06252 22.354401 5.11169481 0.52935431 -1.1337111 0.53800833 0.62043333 0.50070000 -0.11973333 4.676710e-05 1.155052e-14 FALSE TRUE
ENST00000445933 ENSG00000115211 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B4 protein_coding protein_coding 56.03004 78.85538 44.6422 6.93105 0.5552056 -0.8206608 16.23969 21.13060 12.617023 2.58416705 0.59970924 -0.7435016 0.29320417 0.26636667 0.28240000 0.01603333 7.875446e-01 1.155052e-14 FALSE TRUE
ENST00000475582 ENSG00000115211 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B4 protein_coding retained_intron 56.03004 78.85538 44.6422 6.93105 0.5552056 -0.8206608 2.60922 1.19980 3.164065 0.08519562 0.08921316 1.3915625 0.05269583 0.01553333 0.07093333 0.05540000 1.155052e-14 1.155052e-14 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115211 E001 5.122648 0.0681690167 3.328809e-01 4.765503e-01 2 27364352 27364357 6 - 0.622 0.822 0.825
ENSG00000115211 E002 50.312487 0.0006245733 2.540808e-04 1.192194e-03 2 27364358 27364376 19 - 1.522 1.736 0.728
ENSG00000115211 E003 53.775593 0.0016208488 7.998756e-05 4.277885e-04 2 27364377 27364380 4 - 1.534 1.769 0.798
ENSG00000115211 E004 106.619533 0.0028012973 1.435969e-01 2.529075e-01 2 27364381 27364398 18 - 1.948 2.022 0.246
ENSG00000115211 E005 532.654063 0.0022468151 8.099621e-07 6.859098e-06 2 27364399 27364599 201 - 2.587 2.730 0.475
ENSG00000115211 E006 695.786234 0.0014122476 2.551721e-07 2.395876e-06 2 27364718 27364898 181 - 2.720 2.841 0.400
ENSG00000115211 E007 6.512667 0.0027810040 3.433384e-05 2.012202e-04 2 27364899 27365082 184 - 1.123 0.629 -1.914
ENSG00000115211 E008 13.936569 0.0014070698 5.648969e-16 2.205193e-14 2 27365558 27366758 1201 - 1.510 0.787 -2.616
ENSG00000115211 E009 240.303384 0.0002184117 1.378532e-04 6.941652e-04 2 27366759 27366762 4 - 2.276 2.380 0.346
ENSG00000115211 E010 643.632581 0.0011502503 7.152873e-06 4.914199e-05 2 27366763 27366936 174 - 2.701 2.803 0.338
ENSG00000115211 E011 33.984546 0.0112901476 3.797934e-17 1.718021e-15 2 27366937 27367073 137 - 1.854 1.193 -2.269
ENSG00000115211 E012 466.732285 0.0014988329 1.007415e-03 3.984045e-03 2 27367074 27367169 96 - 2.572 2.661 0.295
ENSG00000115211 E013 343.060858 0.0002520234 5.334330e-03 1.684092e-02 2 27367170 27367201 32 - 2.458 2.524 0.221
ENSG00000115211 E014 56.255883 0.0216388347 3.871292e-10 6.189592e-09 2 27367202 27367295 94 - 2.018 1.482 -1.814
ENSG00000115211 E015 53.137271 0.0128825813 9.334515e-11 1.655491e-09 2 27367296 27367456 161 - 1.968 1.495 -1.602
ENSG00000115211 E016 401.100655 0.0007706092 3.333420e-03 1.124497e-02 2 27367457 27367559 103 - 2.520 2.592 0.240
ENSG00000115211 E017 23.836518 0.0071161624 2.020155e-11 4.000338e-10 2 27367560 27367745 186 - 1.654 1.118 -1.862
ENSG00000115211 E018 333.495643 0.0001630458 8.961100e-02 1.745336e-01 2 27367746 27367822 77 - 2.461 2.502 0.139
ENSG00000115211 E019 33.139616 0.0012488472 4.144764e-19 2.386666e-17 2 27367823 27368024 202 - 1.798 1.255 -1.864
ENSG00000115211 E020 354.000145 0.0001828604 8.525688e-01 9.086422e-01 2 27368025 27368113 89 - 2.509 2.519 0.031
ENSG00000115211 E021 250.031835 0.0006959199 6.473924e-01 7.590642e-01 2 27368114 27368139 26 - 2.370 2.362 -0.027
ENSG00000115211 E022 43.046451 0.0004813976 3.003417e-28 4.340109e-26 2 27368140 27368371 232 - 1.925 1.346 -1.974
ENSG00000115211 E023 297.724586 0.0003205805 2.229223e-02 5.628152e-02 2 27368372 27368412 41 - 2.472 2.425 -0.156
ENSG00000115211 E024 299.564820 0.0002844714 2.159118e-02 5.483237e-02 2 27368413 27368463 51 - 2.475 2.428 -0.155
ENSG00000115211 E025 28.169687 0.0121561732 1.624539e-17 7.740545e-16 2 27368464 27368653 190 - 1.796 1.075 -2.498
ENSG00000115211 E026 247.009963 0.0002062886 8.741073e-04 3.523565e-03 2 27368654 27368669 16 - 2.411 2.337 -0.246
ENSG00000115211 E027 287.070124 0.0002035394 3.181464e-03 1.080141e-02 2 27368670 27368733 64 - 2.466 2.406 -0.201
ENSG00000115211 E028 15.219510 0.0011753233 4.636104e-15 1.603023e-13 2 27368734 27369005 272 - 1.522 0.848 -2.415
ENSG00000115211 E029 540.049148 0.0012467600 3.307278e-01 4.743191e-01 2 27369006 27369209 204 - 2.712 2.690 -0.071
ENSG00000115211 E030 144.831275 0.0003187445 7.960386e-01 8.697818e-01 2 27369210 27369212 3 - 2.131 2.128 -0.009
ENSG00000115211 E031 465.802822 0.0046823761 3.612959e-01 5.056958e-01 2 27369414 27369549 136 - 2.656 2.620 -0.118
ENSG00000115211 E032 16.183093 0.0015696798 1.421779e-07 1.402947e-06 2 27369550 27369875 326 - 1.452 1.014 -1.550
ENSG00000115211 E033 274.902299 0.0051138867 2.314747e-01 3.642309e-01 2 27369876 27369919 44 - 2.438 2.387 -0.170
ENSG00000115211 E034 33.574122 0.0316706797 7.378169e-01 8.278852e-01 2 27369920 27370105 186 - 1.523 1.484 -0.131
ENSG00000115211 E035 31.882600 0.0302242413 7.374160e-01 8.276042e-01 2 27370106 27370283 178 - 1.452 1.484 0.111
ENSG00000115211 E036 201.916085 0.0051880145 2.101959e-02 5.363023e-02 2 27370284 27370338 55 - 2.338 2.237 -0.337