ENSG00000115183

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263635 ENSG00000115183 HEK293_OSMI2_2hA HEK293_TMG_2hB TANC1 protein_coding protein_coding 4.354553 3.179233 4.440233 0.2276727 0.2269148 0.4806713 2.3754159 1.95519296 2.3412724 0.09028921 0.1566885 0.2587707 0.55233750 0.61966667 0.52963333 -0.09003333 0.553084430 0.004282629 FALSE TRUE
ENST00000470074 ENSG00000115183 HEK293_OSMI2_2hA HEK293_TMG_2hB TANC1 protein_coding retained_intron 4.354553 3.179233 4.440233 0.2276727 0.2269148 0.4806713 0.6930454 0.96816283 0.2202216 0.20244328 0.2202216 -2.0870514 0.17928333 0.30130000 0.04503333 -0.25626667 0.070879623 0.004282629 FALSE TRUE
MSTRG.19369.2 ENSG00000115183 HEK293_OSMI2_2hA HEK293_TMG_2hB TANC1 protein_coding   4.354553 3.179233 4.440233 0.2276727 0.2269148 0.4806713 0.4944757 0.05617656 0.8247040 0.03198292 0.2564205 3.6568726 0.09922917 0.01863333 0.18220000 0.16356667 0.004282629 0.004282629 FALSE TRUE
MSTRG.19369.5 ENSG00000115183 HEK293_OSMI2_2hA HEK293_TMG_2hB TANC1 protein_coding   4.354553 3.179233 4.440233 0.2276727 0.2269148 0.4806713 0.2986790 0.00000000 0.4003944 0.00000000 0.2425239 5.3589391 0.06052500 0.00000000 0.09546667 0.09546667 0.269239098 0.004282629 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115183 E001 0.2966881 0.0290785164 3.098182e-01   2 158968616 158968625 10 + 0.188 0.000 -10.062
ENSG00000115183 E002 0.5933762 0.0239011940 7.758836e-02 1.555898e-01 2 158968626 158968628 3 + 0.319 0.000 -13.426
ENSG00000115183 E003 0.8857980 0.0136968632 2.185228e-02 5.537297e-02 2 158968629 158968639 11 + 0.419 0.000 -14.058
ENSG00000115183 E004 1.0330470 0.0118313054 1.191172e-02 3.332309e-02 2 158968640 158968648 9 + 0.462 0.000 -14.276
ENSG00000115183 E005 2.9454460 0.0051047375 1.576889e-02 4.221235e-02 2 158968649 158968663 15 + 0.727 0.337 -1.882
ENSG00000115183 E006 13.8176070 0.0015730061 5.090987e-04 2.193578e-03 2 158968664 158968782 119 + 1.282 0.965 -1.141
ENSG00000115183 E007 15.8239850 0.0011578829 6.888194e-03 2.093476e-02 2 159001080 159001189 110 + 1.311 1.092 -0.780
ENSG00000115183 E008 16.9823064 0.0010525929 2.299566e-02 5.774045e-02 2 159065896 159065971 76 + 1.328 1.155 -0.610
ENSG00000115183 E009 27.9910510 0.0028257663 8.799054e-03 2.578190e-02 2 159097637 159097834 198 + 1.528 1.360 -0.579
ENSG00000115183 E010 10.6749107 0.0023491484 1.666141e-01 2.837849e-01 2 159136194 159136198 5 + 1.111 0.983 -0.467
ENSG00000115183 E011 21.8185631 0.0010073687 5.006449e-02 1.092784e-01 2 159136199 159136298 100 + 1.409 1.279 -0.452
ENSG00000115183 E012 0.2214452 0.0402930135 3.530584e-01   2 159147540 159149141 1602 + 0.000 0.144 11.112
ENSG00000115183 E013 9.6199582 0.0232687831 1.314281e-01 2.361329e-01 2 159149142 159149144 3 + 1.092 0.908 -0.679
ENSG00000115183 E014 23.5712693 0.0011797794 1.335598e-02 3.674859e-02 2 159149145 159149272 128 + 1.452 1.288 -0.571
ENSG00000115183 E015 0.1472490 0.0427558281 6.653645e-01   2 159149273 159150369 1097 + 0.104 0.000 -11.353
ENSG00000115183 E016 27.1699759 0.0018590823 4.175513e-02 9.428460e-02 2 159150370 159150556 187 + 1.499 1.375 -0.430
ENSG00000115183 E017 0.0000000       2 159150557 159150777 221 +      
ENSG00000115183 E018 24.4324149 0.0008738194 1.105122e-03 4.320216e-03 2 159163283 159163546 264 + 1.488 1.270 -0.757
ENSG00000115183 E019 20.3087504 0.0032892756 2.037213e-02 5.226618e-02 2 159169250 159169351 102 + 1.395 1.222 -0.604
ENSG00000115183 E020 10.4924478 0.0045063261 9.718952e-01 9.864343e-01 2 159169352 159169372 21 + 1.052 1.063 0.040
ENSG00000115183 E021 35.4852044 0.0048300910 1.135937e-01 2.107778e-01 2 159170524 159170805 282 + 1.605 1.518 -0.296
ENSG00000115183 E022 22.8019537 0.0008525856 8.879802e-02 1.732798e-01 2 159172121 159172272 152 + 1.427 1.321 -0.366
ENSG00000115183 E023 29.6360685 0.0006529902 2.809657e-01 4.208287e-01 2 159174953 159175184 232 + 1.510 1.459 -0.177
ENSG00000115183 E024 26.3059032 0.0007891052 5.426578e-01 6.733797e-01 2 159176352 159176518 167 + 1.413 1.471 0.197
ENSG00000115183 E025 74.8044734 0.0017801756 3.617868e-01 5.062070e-01 2 159178556 159179163 608 + 1.855 1.913 0.193
ENSG00000115183 E026 26.7978508 0.0007758701 7.722523e-01 8.529845e-01 2 159185791 159185899 109 + 1.444 1.441 -0.010
ENSG00000115183 E027 32.1943753 0.0006556107 8.778508e-01 9.255565e-01 2 159186902 159187024 123 + 1.518 1.525 0.024
ENSG00000115183 E028 40.3055741 0.0007367113 4.942504e-01 6.312095e-01 2 159194257 159194493 237 + 1.625 1.603 -0.072
ENSG00000115183 E029 32.6917572 0.0006845474 6.571821e-01 7.665999e-01 2 159196608 159196793 186 + 1.510 1.554 0.149
ENSG00000115183 E030 16.5923372 0.0011232080 8.408031e-01 9.006334e-01 2 159198975 159199017 43 + 1.236 1.269 0.116
ENSG00000115183 E031 18.8088181 0.0028416402 1.543703e-01 2.675883e-01 2 159199018 159199053 36 + 1.236 1.367 0.456
ENSG00000115183 E032 27.3239430 0.0025008602 1.682395e-01 2.859130e-01 2 159217497 159217630 134 + 1.399 1.509 0.378
ENSG00000115183 E033 24.1850943 0.0067249585 7.766270e-01 8.561467e-01 2 159219238 159219361 124 + 1.385 1.422 0.127
ENSG00000115183 E034 8.0504489 0.0414389912 5.146239e-01 6.493536e-01 2 159219362 159219691 330 + 0.904 1.002 0.367
ENSG00000115183 E035 26.7405670 0.0007543248 1.778186e-03 6.530172e-03 2 159219692 159219867 176 + 1.525 1.329 -0.675
ENSG00000115183 E036 27.7318204 0.0007698170 2.796710e-03 9.664520e-03 2 159224232 159224364 133 + 1.535 1.352 -0.630
ENSG00000115183 E037 2.0220973 0.0197909085 1.726074e-01 2.915968e-01 2 159224393 159225687 1295 + 0.569 0.337 -1.204
ENSG00000115183 E038 21.1558001 0.0038341138 1.349191e-01 2.409823e-01 2 159225688 159225779 92 + 1.390 1.287 -0.357
ENSG00000115183 E039 2.7545674 0.0799905395 2.791870e-01 4.189009e-01 2 159225780 159227818 2039 + 0.656 0.467 -0.867
ENSG00000115183 E040 30.7560724 0.0038537690 6.561584e-01 7.658583e-01 2 159227819 159227965 147 + 1.511 1.498 -0.044
ENSG00000115183 E041 4.4101433 0.0296427754 9.367773e-01 9.642470e-01 2 159227966 159228795 830 + 0.727 0.726 -0.007
ENSG00000115183 E042 26.3405033 0.0009193519 6.976935e-01 7.977593e-01 2 159228796 159228896 101 + 1.444 1.435 -0.032
ENSG00000115183 E043 226.9894382 0.0002319517 1.444247e-06 1.159258e-05 2 159229578 159231892 2315 + 2.299 2.420 0.404
ENSG00000115183 E044 93.4969445 0.0124136586 7.909930e-11 1.419987e-09 2 159231893 159232659 767 + 1.729 2.156 1.436
ENSG00000115183 E045 0.2934659 0.0287660948 8.121032e-01   2 159234381 159234427 47 + 0.104 0.143 0.530