ENSG00000115170

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263640 ENSG00000115170 HEK293_OSMI2_2hA HEK293_TMG_2hB ACVR1 protein_coding protein_coding 4.776154 3.515593 5.148728 0.2937517 0.2313125 0.5491493 0.4060701 0.2229801 0.5898515 0.2229801 0.58985152 1.3643985 0.1006792 0.05893333 0.1252333 0.0663000 9.629185e-01 5.16321e-09 FALSE TRUE
ENST00000410057 ENSG00000115170 HEK293_OSMI2_2hA HEK293_TMG_2hB ACVR1 protein_coding protein_coding 4.776154 3.515593 5.148728 0.2937517 0.2313125 0.5491493 0.5154690 0.0000000 1.1486268 0.0000000 0.23536663 6.8562721 0.0881875 0.00000000 0.2246000 0.2246000 5.163210e-09 5.16321e-09 FALSE TRUE
ENST00000434821 ENSG00000115170 HEK293_OSMI2_2hA HEK293_TMG_2hB ACVR1 protein_coding protein_coding 4.776154 3.515593 5.148728 0.2937517 0.2313125 0.5491493 0.9220328 0.4811758 1.6687052 0.1741528 0.09797862 1.7730374 0.1946708 0.14566667 0.3243000 0.1786333 1.668452e-01 5.16321e-09 FALSE TRUE
ENST00000682690 ENSG00000115170 HEK293_OSMI2_2hA HEK293_TMG_2hB ACVR1 protein_coding processed_transcript 4.776154 3.515593 5.148728 0.2937517 0.2313125 0.5491493 2.3737561 2.4287771 1.4786345 0.4494793 0.77032543 -0.7121683 0.5108958 0.67790000 0.2745000 -0.4034000 4.027745e-01 5.16321e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115170 E001 0.1817044 0.0419090114 3.708928e-01   2 157736251 157736443 193 - 0.000 0.142 10.907
ENSG00000115170 E002 0.0000000       2 157736444 157736445 2 -      
ENSG00000115170 E003 0.5848540 0.0757749572 5.302057e-02 1.145204e-01 2 157736446 157736448 3 - 0.000 0.335 14.317
ENSG00000115170 E004 1.3232866 0.0138265119 2.023139e-02 5.196984e-02 2 157736449 157736460 12 - 0.105 0.521 3.075
ENSG00000115170 E005 2.0596560 0.0517450272 1.353029e-02 3.714996e-02 2 157736461 157736502 42 - 0.190 0.654 2.675
ENSG00000115170 E006 2.4326166 0.0929297067 3.147963e-02 7.484402e-02 2 157736503 157736520 18 - 0.261 0.695 2.259
ENSG00000115170 E007 22.4216918 0.0012313527 5.726387e-07 5.009451e-06 2 157736521 157736621 101 - 1.144 1.533 1.358
ENSG00000115170 E008 104.7087155 0.0080722716 7.706330e-06 5.254305e-05 2 157736622 157737315 694 - 1.892 2.138 0.822
ENSG00000115170 E009 81.7408307 0.0051694029 1.544592e-01 2.676984e-01 2 157737316 157737665 350 - 1.870 1.965 0.318
ENSG00000115170 E010 42.0426660 0.0018309271 6.493871e-01 7.606732e-01 2 157738440 157738564 125 - 1.608 1.656 0.162
ENSG00000115170 E011 19.8779200 0.0053030530 8.903944e-01 9.339757e-01 2 157738565 157738570 6 - 1.301 1.331 0.107
ENSG00000115170 E012 0.3289534 0.0303489411 8.342716e-01   2 157738571 157741654 3084 - 0.105 0.142 0.487
ENSG00000115170 E013 0.4428904 0.4100310722 2.149171e-01 3.443352e-01 2 157760876 157760879 4 - 0.000 0.257 13.394
ENSG00000115170 E014 42.4066599 0.0020299920 9.218594e-01 9.546908e-01 2 157760880 157761077 198 - 1.626 1.641 0.053
ENSG00000115170 E015 0.0000000       2 157761078 157761742 665 -      
ENSG00000115170 E016 0.1482932 0.0413813170 3.733382e-01   2 157764127 157764437 311 - 0.000 0.141 12.848
ENSG00000115170 E017 50.8965764 0.0004327973 6.237492e-01 7.402451e-01 2 157765921 157766196 276 - 1.691 1.737 0.155
ENSG00000115170 E018 39.1589601 0.0006551123 4.250350e-01 5.679775e-01 2 157770368 157770514 147 - 1.572 1.637 0.224
ENSG00000115170 E019 0.0000000       2 157770515 157771365 851 -      
ENSG00000115170 E020 31.1631241 0.0007079650 3.879371e-02 8.879997e-02 2 157774088 157774187 100 - 1.552 1.447 -0.361
ENSG00000115170 E021 19.9937436 0.0009644163 1.398848e-03 5.303332e-03 2 157778131 157778149 19 - 1.411 1.183 -0.795
ENSG00000115170 E022 33.1461279 0.0006365312 1.872092e-04 9.089474e-04 2 157778150 157778342 193 - 1.614 1.409 -0.703
ENSG00000115170 E023 15.2572094 0.0012294467 8.880873e-02 1.732953e-01 2 157780337 157780405 69 - 1.263 1.137 -0.446
ENSG00000115170 E024 10.3333114 0.0018055296 1.388080e-01 2.464504e-01 2 157780406 157780407 2 - 1.108 0.977 -0.480
ENSG00000115170 E025 34.6358214 0.0006288736 2.232745e-04 1.063155e-03 2 157780408 157780600 193 - 1.631 1.434 -0.674
ENSG00000115170 E026 0.0000000       2 157790132 157790237 106 -      
ENSG00000115170 E027 0.0000000       2 157792770 157792853 84 -      
ENSG00000115170 E028 15.3421096 0.0011592500 1.536062e-04 7.631046e-04 2 157799427 157799428 2 - 1.329 1.011 -1.138
ENSG00000115170 E029 21.5051845 0.0011823464 9.746766e-05 5.101521e-04 2 157799429 157799500 72 - 1.459 1.183 -0.962
ENSG00000115170 E030 0.0000000       2 157806737 157806996 260 -      
ENSG00000115170 E031 2.0358243 0.0394750490 3.044148e-01 4.464246e-01 2 157818269 157818376 108 - 0.376 0.569 0.974
ENSG00000115170 E032 1.2449508 0.2441433475 2.497704e-01 3.856450e-01 2 157818377 157818384 8 - 0.190 0.472 1.838
ENSG00000115170 E033 21.7507031 0.0223993920 7.042457e-03 2.133413e-02 2 157818385 157818559 175 - 1.455 1.197 -0.900
ENSG00000115170 E034 0.1817044 0.0419090114 3.708928e-01   2 157819403 157819489 87 - 0.000 0.142 12.851
ENSG00000115170 E035 0.4804688 0.0210991163 7.459498e-01 8.338425e-01 2 157826528 157826646 119 - 0.190 0.142 -0.513
ENSG00000115170 E036 0.1482932 0.0413813170 3.733382e-01   2 157838241 157838327 87 - 0.000 0.141 12.848
ENSG00000115170 E037 0.3666179 0.0294060222 8.342933e-01 8.962538e-01 2 157860033 157860054 22 - 0.105 0.142 0.490
ENSG00000115170 E038 0.3666179 0.0294060222 8.342933e-01 8.962538e-01 2 157860055 157860179 125 - 0.105 0.142 0.490
ENSG00000115170 E039 0.0000000       2 157874864 157875111 248 -      
ENSG00000115170 E040 0.0000000       2 157875535 157875741 207 -      
ENSG00000115170 E041 0.3289534 0.0303489411 8.342716e-01   2 157875742 157875795 54 - 0.105 0.142 0.487
ENSG00000115170 E042 9.3828965 0.0234387032 1.063103e-01 2.000990e-01 2 157875796 157876330 535 - 1.089 0.901 -0.697