ENSG00000115159

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310454 ENSG00000115159 HEK293_OSMI2_2hA HEK293_TMG_2hB GPD2 protein_coding protein_coding 5.43745 1.849153 10.00648 0.3882363 0.294847 2.429658 0.88707272 0.07726891 2.504026 0.04281517 0.07011424 4.848388 0.11817500 0.05253333 0.2509 0.1983667 0.01670245 0.01670245 FALSE TRUE
ENST00000409674 ENSG00000115159 HEK293_OSMI2_2hA HEK293_TMG_2hB GPD2 protein_coding protein_coding 5.43745 1.849153 10.00648 0.3882363 0.294847 2.429658 0.08644743 0.15074137 0.000000 0.15074137 0.00000000 -4.006669 0.05740417 0.10576667 0.0000 -0.1057667 0.55337471 0.01670245 FALSE TRUE
ENST00000438166 ENSG00000115159 HEK293_OSMI2_2hA HEK293_TMG_2hB GPD2 protein_coding protein_coding 5.43745 1.849153 10.00648 0.3882363 0.294847 2.429658 3.78885943 0.45742561 7.016728 0.23170798 0.39237840 3.910044 0.52694583 0.23366667 0.7001 0.4664333 0.09368382 0.01670245 FALSE TRUE
ENST00000492005 ENSG00000115159 HEK293_OSMI2_2hA HEK293_TMG_2hB GPD2 protein_coding processed_transcript 5.43745 1.849153 10.00648 0.3882363 0.294847 2.429658 0.09163713 0.26051729 0.000000 0.26051729 0.00000000 -4.757649 0.06179167 0.18280000 0.0000 -0.1828000 0.59812967 0.01670245 FALSE FALSE
ENST00000496190 ENSG00000115159 HEK293_OSMI2_2hA HEK293_TMG_2hB GPD2 protein_coding processed_transcript 5.43745 1.849153 10.00648 0.3882363 0.294847 2.429658 0.31496719 0.85062424 0.000000 0.52997423 0.00000000 -6.427312 0.18129167 0.39366667 0.0000 -0.3936667 0.03790861 0.01670245   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115159 E001 0.1472490 0.0454961657 7.751432e-01   2 156435290 156435409 120 + 0.043 0.000 -15.788
ENSG00000115159 E002 11.3674524 0.0021823680 1.090548e-02 3.093432e-02 2 156435441 156435804 364 + 0.930 0.612 -1.282
ENSG00000115159 E003 7.1245487 0.0026011278 1.594017e-01 2.743168e-01 2 156436379 156436426 48 + 0.750 0.611 -0.585
ENSG00000115159 E004 11.4726808 0.0047628664 3.655294e-01 5.098433e-01 2 156436427 156436484 58 + 0.914 0.914 0.000
ENSG00000115159 E005 11.3370851 0.0015232098 6.112092e-01 7.303761e-01 2 156436485 156436513 29 + 0.903 0.965 0.235
ENSG00000115159 E006 0.8148214 0.0244297725 6.108840e-01 7.301356e-01 2 156436514 156436615 102 + 0.150 0.308 1.325
ENSG00000115159 E007 0.0000000       2 156473572 156473591 20 +      
ENSG00000115159 E008 0.0000000       2 156473592 156473636 45 +      
ENSG00000115159 E009 34.7807287 0.0030062881 6.882847e-04 2.856186e-03 2 156476098 156476207 110 + 1.374 1.158 -0.759
ENSG00000115159 E010 0.0000000       2 156495562 156495691 130 +      
ENSG00000115159 E011 46.6214914 0.0111232545 1.138372e-05 7.467494e-05 2 156496044 156496215 172 + 1.503 1.157 -1.208
ENSG00000115159 E012 0.5985731 0.0212361423 4.679015e-01 6.073425e-01 2 156501785 156501879 95 + 0.117 0.307 1.735
ENSG00000115159 E013 0.2998086 0.0279279249 1.551998e-01   2 156501880 156501881 2 + 0.043 0.307 3.320
ENSG00000115159 E014 18.4397155 0.0010115943 4.536076e-03 1.464312e-02 2 156510796 156510796 1 + 1.115 0.856 -0.963
ENSG00000115159 E015 39.7110552 0.0005630357 2.746852e-05 1.648772e-04 2 156510797 156510920 124 + 1.432 1.158 -0.960
ENSG00000115159 E016 32.8521484 0.0099012260 4.220840e-03 1.376007e-02 2 156512220 156512317 98 + 1.347 1.157 -0.667
ENSG00000115159 E017 37.6465226 0.0074319645 2.120988e-03 7.598903e-03 2 156513333 156513496 164 + 1.403 1.216 -0.655
ENSG00000115159 E018 34.8683303 0.0008030405 1.148514e-03 4.466262e-03 2 156549608 156549772 165 + 1.372 1.188 -0.645
ENSG00000115159 E019 37.3085027 0.0005651765 1.634772e-03 6.072483e-03 2 156550602 156550746 145 + 1.399 1.242 -0.548
ENSG00000115159 E020 45.0109567 0.0046116325 1.136126e-02 3.203007e-02 2 156557389 156557551 163 + 1.473 1.391 -0.280
ENSG00000115159 E021 27.7693374 0.0006865333 3.305017e-02 7.790731e-02 2 156557552 156557582 31 + 1.269 1.188 -0.288
ENSG00000115159 E022 48.4475603 0.0004412075 2.948897e-02 7.094541e-02 2 156568825 156568959 135 + 1.498 1.474 -0.080
ENSG00000115159 E023 65.9814857 0.0004252079 2.762413e-02 6.726272e-02 2 156569363 156569538 176 + 1.624 1.625 0.004
ENSG00000115159 E024 44.1493302 0.0040744330 7.374485e-02 1.495172e-01 2 156570087 156570218 132 + 1.456 1.443 -0.043
ENSG00000115159 E025 30.0783884 0.0065574918 4.621251e-01 6.020162e-01 2 156571134 156571171 38 + 1.288 1.354 0.231
ENSG00000115159 E026 43.6273318 0.0005709783 2.749250e-01 4.141517e-01 2 156571172 156571292 121 + 1.443 1.503 0.207
ENSG00000115159 E027 41.3378035 0.0006175574 2.614085e-01 3.990608e-01 2 156578889 156579001 113 + 1.420 1.475 0.188
ENSG00000115159 E028 0.5954526 0.0172671820 1.000000e+00 1.000000e+00 2 156579002 156579082 81 + 0.150 0.000 -17.779
ENSG00000115159 E029 0.5954526 0.0172671820 1.000000e+00 1.000000e+00 2 156579083 156579085 3 + 0.150 0.000 -17.779
ENSG00000115159 E030 34.0426150 0.0006172830 9.458575e-02 1.822610e-01 2 156579086 156579164 79 + 1.344 1.334 -0.035
ENSG00000115159 E031 0.1515154 0.0448189543 7.747451e-01   2 156579686 156579689 4 + 0.043 0.000 -15.779
ENSG00000115159 E032 29.8304555 0.0124945340 4.861545e-01 6.239618e-01 2 156579690 156579788 99 + 1.281 1.336 0.191
ENSG00000115159 E033 44.8918694 0.0025431411 3.397684e-01 4.836950e-01 2 156582793 156582914 122 + 1.451 1.518 0.228
ENSG00000115159 E034 459.2940562 0.0109548141 1.114030e-13 3.143428e-12 2 156582915 156586403 3489 + 2.395 2.785 1.300
ENSG00000115159 E035 0.0000000       2 156610724 156610849 126 +      
ENSG00000115159 E036 0.1515154 0.0448189543 7.747451e-01   2 156613475 156613735 261 + 0.043 0.000 -15.779