ENSG00000115091

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263238 ENSG00000115091 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR3 protein_coding protein_coding 51.56879 16.70334 86.44792 0.5448566 4.119349 2.370998 10.86211 6.268867 17.54004 0.7633276 0.9349797 1.482898 0.2562792 0.3735667 0.2028000 -0.17076667 0.0001365791 0.0001331086 FALSE TRUE
ENST00000443297 ENSG00000115091 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR3 protein_coding protein_coding 51.56879 16.70334 86.44792 0.5448566 4.119349 2.370998 15.01526 3.083996 27.03396 0.2606937 1.3579880 3.127763 0.2498917 0.1852333 0.3126000 0.12736667 0.0001331086 0.0001331086   FALSE
ENST00000446821 ENSG00000115091 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR3 protein_coding nonsense_mediated_decay 51.56879 16.70334 86.44792 0.5448566 4.119349 2.370998 23.67243 6.848005 38.32027 0.1588722 2.0397196 2.482623 0.4537375 0.4113667 0.4430333 0.03166667 0.6091981620 0.0001331086 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115091 E001 4.1956863 0.0041159394 8.813354e-02 1.722812e-01 2 113889801 113889848 48 + 0.723 0.455 -1.211
ENSG00000115091 E002 5.4314404 0.0030075008 3.247646e-01 4.681821e-01 2 113890046 113890062 17 + 0.789 0.672 -0.475
ENSG00000115091 E003 6.0205503 0.0026187752 1.905887e-01 3.144997e-01 2 113890063 113890064 2 + 0.835 0.672 -0.655
ENSG00000115091 E004 21.2028087 0.0008354877 3.829670e-03 1.266398e-02 2 113890065 113890084 20 + 1.338 1.105 -0.823
ENSG00000115091 E005 26.3170507 0.0007029250 8.124694e-04 3.303650e-03 2 113890085 113890088 4 + 1.430 1.182 -0.867
ENSG00000115091 E006 34.9792187 0.0006285073 7.516038e-03 2.255454e-02 2 113890089 113890092 4 + 1.531 1.377 -0.528
ENSG00000115091 E007 47.7841383 0.0004368603 7.079311e-05 3.839439e-04 2 113890093 113890097 5 + 1.673 1.459 -0.732
ENSG00000115091 E008 147.6630091 0.0112965369 1.567507e-03 5.853963e-03 2 113890098 113890171 74 + 2.148 1.980 -0.563
ENSG00000115091 E009 266.7971614 0.0014801789 4.269948e-10 6.770978e-09 2 113890172 113890323 152 + 2.403 2.240 -0.544
ENSG00000115091 E010 0.5911862 0.0193874923 3.232838e-01 4.665915e-01 2 113890598 113890778 181 + 0.227 0.000 -9.648
ENSG00000115091 E011 191.3768156 0.0001907346 8.456390e-08 8.706727e-07 2 113913172 113913227 56 + 2.253 2.126 -0.423
ENSG00000115091 E012 314.6595566 0.0001732017 1.382586e-06 1.113634e-05 2 113916884 113917008 125 + 2.457 2.382 -0.249
ENSG00000115091 E013 222.4330443 0.0002266015 3.647292e-02 8.447978e-02 2 113927345 113927368 24 + 2.293 2.276 -0.058
ENSG00000115091 E014 331.2614645 0.0009156307 3.519106e-01 4.961185e-01 2 113927369 113927455 87 + 2.457 2.471 0.048
ENSG00000115091 E015 344.2370754 0.0004356026 3.370410e-02 7.916413e-02 2 113931301 113931396 96 + 2.480 2.470 -0.033
ENSG00000115091 E016 2.0755546 0.0069256097 5.494383e-01 6.791685e-01 2 113933856 113934278 423 + 0.406 0.540 0.678
ENSG00000115091 E017 333.4199550 0.0001443526 3.316428e-01 4.752834e-01 2 113934279 113934383 105 + 2.459 2.479 0.066
ENSG00000115091 E018 173.7437602 0.0016014151 4.751176e-02 1.047537e-01 2 113934384 113934386 3 + 2.190 2.155 -0.115
ENSG00000115091 E019 0.8052696 0.2073366014 4.499627e-01 5.911437e-01 2 113934387 113934640 254 + 0.180 0.350 1.271
ENSG00000115091 E020 384.7543124 0.0003663973 1.221729e-02 3.405271e-02 2 113939959 113940102 144 + 2.529 2.514 -0.052
ENSG00000115091 E021 0.2924217 0.0274228856 8.372299e-01   2 113940103 113940143 41 + 0.128 0.000 -8.648
ENSG00000115091 E022 426.1201566 0.0015758557 5.810368e-01 7.056495e-01 2 113942186 113942359 174 + 2.563 2.585 0.074
ENSG00000115091 E023 1.4038426 0.0103071703 5.039001e-01 6.398325e-01 2 113950824 113951478 655 + 0.307 0.455 0.847
ENSG00000115091 E024 352.8407043 0.0004134660 3.362056e-01 4.800218e-01 2 113951479 113951571 93 + 2.483 2.502 0.061
ENSG00000115091 E025 457.8573453 0.0005573589 7.685305e-01 8.504142e-01 2 113951720 113951845 126 + 2.590 2.637 0.158
ENSG00000115091 E026 12.1353904 0.0021384514 5.253717e-01 6.587514e-01 2 113951846 113955622 3777 + 1.039 1.145 0.381
ENSG00000115091 E027 374.9067545 0.0006163098 1.004843e-01 1.911904e-01 2 113955623 113955706 84 + 2.495 2.574 0.266
ENSG00000115091 E028 1326.7402979 0.0032663520 4.241286e-12 9.382284e-11 2 113957360 113962596 5237 + 3.001 3.206 0.681