ENSG00000115073

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289228 ENSG00000115073 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR1B protein_coding protein_coding 48.07638 70.33893 38.78789 3.537624 1.356627 -0.8585502 38.190123 63.375649 29.264432 2.9879647 0.6262221 -1.1145151 0.7698125 0.9013 0.7552000 -0.14610000 2.060023e-17 1.925735e-19 FALSE TRUE
ENST00000451664 ENSG00000115073 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR1B protein_coding retained_intron 48.07638 70.33893 38.78789 3.537624 1.356627 -0.8585502 6.914858 4.560249 6.358003 0.2623895 0.3896925 0.4785682 0.1627958 0.0648 0.1636333 0.09883333 1.925735e-19 1.925735e-19 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115073 E001 922.49323 0.0035564441 2.775560e-05 1.663834e-04 2 97655939 97656556 618 - 2.818 2.953 0.450
ENSG00000115073 E002 971.90957 0.0001586721 9.286248e-13 2.292782e-11 2 97656557 97656960 404 - 2.862 2.967 0.348
ENSG00000115073 E003 380.60977 0.0012077885 2.319272e-01 3.647480e-01 2 97657152 97657192 41 - 2.500 2.544 0.145
ENSG00000115073 E004 464.84917 0.0006566814 2.871332e-02 6.942848e-02 2 97657448 97657509 62 - 2.575 2.634 0.196
ENSG00000115073 E005 374.55239 0.0006838212 3.338668e-02 7.854906e-02 2 97657943 97657977 35 - 2.478 2.540 0.207
ENSG00000115073 E006 575.03975 0.0005494474 1.581864e-01 2.726986e-01 2 97657978 97658117 140 - 2.682 2.721 0.131
ENSG00000115073 E007 445.62827 0.0012794890 5.755797e-01 7.011495e-01 2 97658224 97658316 93 - 2.601 2.601 0.001
ENSG00000115073 E008 602.90071 0.0005250909 1.434299e-03 5.420838e-03 2 97658427 97658643 217 - 2.765 2.720 -0.147
ENSG00000115073 E009 71.93033 0.0007179943 8.965910e-14 2.565808e-12 2 97658644 97658813 170 - 2.015 1.705 -1.045
ENSG00000115073 E010 47.92255 0.0245601816 1.483087e-03 5.582291e-03 2 97658814 97658878 65 - 1.828 1.544 -0.965
ENSG00000115073 E011 377.63538 0.0004332595 2.134859e-06 1.650180e-05 2 97658879 97659003 125 - 2.592 2.505 -0.291
ENSG00000115073 E012 412.55633 0.0001610205 5.403804e-05 3.019510e-04 2 97659352 97659477 126 - 2.613 2.549 -0.214
ENSG00000115073 E013 12.74839 0.0017764300 1.544814e-01 2.677318e-01 2 97659478 97659891 414 - 1.181 1.053 -0.461
ENSG00000115073 E014 299.67187 0.0002151067 1.088368e-06 8.963140e-06 2 97660571 97660646 76 - 2.494 2.398 -0.321
ENSG00000115073 E015 215.47537 0.0009695415 9.204065e-07 7.698377e-06 2 97661882 97661946 65 - 2.374 2.245 -0.430
ENSG00000115073 E016 21.47177 0.0223447393 3.411672e-05 2.001211e-04 2 97663452 97663842 391 - 1.551 1.144 -1.419
ENSG00000115073 E017 127.55786 0.0020025306 1.063596e-04 5.512557e-04 2 97663843 97664044 202 - 2.154 2.016 -0.460