ENSG00000115041

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360990 ENSG00000115041 HEK293_OSMI2_2hA HEK293_TMG_2hB KCNIP3 protein_coding protein_coding 1.641381 3.375153 0.9279031 0.1798654 0.0867973 -1.85171 0.37684777 1.68905007 0.0000000 0.07520245 0.00000000 -7.4085846 0.22364583 0.50243333 0.0000000 -0.50243333 4.704563e-14 4.704563e-14 FALSE TRUE
ENST00000461336 ENSG00000115041 HEK293_OSMI2_2hA HEK293_TMG_2hB KCNIP3 protein_coding processed_transcript 1.641381 3.375153 0.9279031 0.1798654 0.0867973 -1.85171 0.09007391 0.09475133 0.0000000 0.09475133 0.00000000 -3.3888966 0.05418333 0.02643333 0.0000000 -0.02643333 9.880456e-01 4.704563e-14 FALSE FALSE
ENST00000468529 ENSG00000115041 HEK293_OSMI2_2hA HEK293_TMG_2hB KCNIP3 protein_coding protein_coding 1.641381 3.375153 0.9279031 0.1798654 0.0867973 -1.85171 1.13352850 1.56828637 0.8940925 0.11801023 0.05451396 -0.8038166 0.69292500 0.46350000 0.9691667 0.50566667 2.561773e-11 4.704563e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115041 E001 0.2998086 0.0284999694 0.3297313024   2 95297327 95297337 11 + 0.214 0.067 -1.933
ENSG00000115041 E002 0.2998086 0.0284999694 0.3297313024   2 95297338 95297346 9 + 0.214 0.067 -1.933
ENSG00000115041 E003 0.2998086 0.0284999694 0.3297313024   2 95297347 95297453 107 + 0.214 0.067 -1.933
ENSG00000115041 E004 0.2998086 0.0284999694 0.3297313024   2 95298683 95299120 438 + 0.214 0.067 -1.933
ENSG00000115041 E005 1.1331762 0.1087963603 0.8178349502 0.884814785 2 95303044 95303503 460 + 0.214 0.267 0.417
ENSG00000115041 E006 0.0000000       2 95310222 95310236 15 +      
ENSG00000115041 E007 0.0000000       2 95310355 95310520 166 +      
ENSG00000115041 E008 0.0000000       2 95310521 95313896 3376 +      
ENSG00000115041 E009 9.6466130 0.0021469323 0.0002499794 0.001175162 2 95346728 95347122 395 + 1.211 0.813 -1.470
ENSG00000115041 E010 0.2214452 0.0379320809 1.0000000000   2 95355037 95355282 246 + 0.000 0.067 7.371
ENSG00000115041 E011 13.8534478 0.0013230237 0.0558376717 0.119411193 2 95374296 95374420 125 + 1.211 1.021 -0.682
ENSG00000115041 E012 15.2916374 0.0012516444 0.7641938682 0.847321716 2 95374848 95374917 70 + 1.072 1.103 0.112
ENSG00000115041 E013 19.9688250 0.0012341167 0.7270570284 0.819907811 2 95375138 95375208 71 + 1.227 1.195 -0.113
ENSG00000115041 E014 17.9736865 0.0012031437 0.9553710427 0.975998975 2 95381596 95381703 108 + 1.157 1.162 0.018
ENSG00000115041 E015 15.0143558 0.0013393478 0.5673747492 0.694206375 2 95382377 95382481 105 + 1.048 1.108 0.219
ENSG00000115041 E016 10.9223013 0.0019121334 0.8298821921 0.893194686 2 95383232 95383294 63 + 0.995 0.970 -0.094
ENSG00000115041 E017 137.4995949 0.0003979423 0.0092414841 0.026889853 2 95384002 95386077 2076 + 1.966 2.035 0.231