ENSG00000115020

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264380 ENSG00000115020 HEK293_OSMI2_2hA HEK293_TMG_2hB PIKFYVE protein_coding protein_coding 5.331109 1.433812 8.009622 0.1139096 0.1198413 2.473651 2.21086366 0.20919856 3.672322 0.12043202 0.4191636 4.0703056 0.34595833 0.13773333 0.4602 0.32246667 1.055470e-01 8.846354e-08 FALSE TRUE
ENST00000392202 ENSG00000115020 HEK293_OSMI2_2hA HEK293_TMG_2hB PIKFYVE protein_coding protein_coding 5.331109 1.433812 8.009622 0.1139096 0.1198413 2.473651 0.03611418 0.07866410 0.000000 0.04600006 0.0000000 -3.1483500 0.02179583 0.05166667 0.0000 -0.05166667 6.371558e-03 8.846354e-08 FALSE TRUE
MSTRG.19881.2 ENSG00000115020 HEK293_OSMI2_2hA HEK293_TMG_2hB PIKFYVE protein_coding   5.331109 1.433812 8.009622 0.1139096 0.1198413 2.473651 0.98032473 0.08527293 1.765037 0.08527293 0.4591424 4.2196389 0.16795417 0.06356667 0.2192 0.15563333 2.255201e-01 8.846354e-08 FALSE TRUE
MSTRG.19881.7 ENSG00000115020 HEK293_OSMI2_2hA HEK293_TMG_2hB PIKFYVE protein_coding   5.331109 1.433812 8.009622 0.1139096 0.1198413 2.473651 1.53501547 0.96912806 1.594188 0.01508820 0.2439037 0.7122742 0.38878333 0.68243333 0.1986 -0.48383333 8.846354e-08 8.846354e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115020 E001 1.6327659 0.0088587064 1.526050e-01 2.652187e-01 2 208266255 208266266 12 + 0.336 0.000 -19.672
ENSG00000115020 E002 1.9251877 0.0075894677 1.055899e-01 1.989981e-01 2 208266267 208266277 11 + 0.376 0.000 -19.902
ENSG00000115020 E003 2.7001545 0.0055231969 2.778039e-01 4.174197e-01 2 208266278 208266342 65 + 0.448 0.301 -0.854
ENSG00000115020 E004 1.3556576 0.0120555330 8.460762e-01 9.042916e-01 2 208266343 208266356 14 + 0.267 0.301 0.234
ENSG00000115020 E005 1.2041422 0.1263592127 1.000000e+00 1.000000e+00 2 208266357 208266362 6 + 0.241 0.301 0.433
ENSG00000115020 E006 5.5869321 0.0320854585 6.749986e-01 7.804054e-01 2 208266363 208266415 53 + 0.653 0.699 0.193
ENSG00000115020 E007 21.0286095 0.0155391408 8.256256e-03 2.443217e-02 2 208271511 208271691 181 + 1.176 0.955 -0.805
ENSG00000115020 E008 20.8450418 0.0705572785 4.551358e-02 1.011367e-01 2 208273584 208273733 150 + 1.169 0.963 -0.752
ENSG00000115020 E009 0.3729606 0.0284641409 1.783724e-01 2.990982e-01 2 208274018 208274020 3 + 0.044 0.301 3.236
ENSG00000115020 E010 0.9620705 0.0121989077 8.192449e-01 8.858616e-01 2 208274021 208274053 33 + 0.185 0.301 0.913
ENSG00000115020 E011 13.3208508 0.0020425513 1.092549e-01 2.044531e-01 2 208276712 208276830 119 + 0.982 0.903 -0.298
ENSG00000115020 E012 13.8345048 0.0017370477 7.954279e-02 1.588152e-01 2 208277537 208277708 172 + 1.001 0.902 -0.368
ENSG00000115020 E013 26.4998069 0.0007883299 2.034650e-05 1.259545e-04 2 208285726 208285933 208 + 1.280 0.902 -1.368
ENSG00000115020 E014 22.7836961 0.0008001085 9.330120e-04 3.729823e-03 2 208288729 208288818 90 + 1.212 0.954 -0.936
ENSG00000115020 E015 32.6926354 0.0006354456 8.765786e-03 2.569754e-02 2 208298641 208298779 139 + 1.349 1.254 -0.330
ENSG00000115020 E016 31.3762024 0.0011056551 7.399881e-04 3.042735e-03 2 208300937 208301094 158 + 1.340 1.145 -0.688
ENSG00000115020 E017 26.4185799 0.0048958276 9.616918e-02 1.846267e-01 2 208302242 208302353 112 + 1.252 1.230 -0.078
ENSG00000115020 E018 0.2934659 0.0299763183 1.789097e-01   2 208302354 208302580 227 + 0.044 0.300 3.231
ENSG00000115020 E019 28.0005555 0.0006972060 1.227504e-01 2.238827e-01 2 208304171 208304300 130 + 1.272 1.278 0.020
ENSG00000115020 E020 14.4562838 0.0012073419 3.703420e-01 5.147822e-01 2 208304301 208304318 18 + 1.005 1.041 0.129
ENSG00000115020 E021 27.2782478 0.0027483713 8.232669e-01 8.886312e-01 2 208304846 208305013 168 + 1.244 1.380 0.473
ENSG00000115020 E022 6.6806169 0.0024679189 1.094448e-02 3.102868e-02 2 208305014 208305549 536 + 0.621 1.113 1.912
ENSG00000115020 E023 20.8945345 0.0009372059 8.465699e-03 2.495151e-02 2 208312236 208312295 60 + 1.170 0.999 -0.618
ENSG00000115020 E024 24.9652131 0.0007779629 5.341649e-05 2.988393e-04 2 208314294 208314423 130 + 1.257 0.902 -1.290
ENSG00000115020 E025 29.9274648 0.0006247598 2.761050e-07 2.574050e-06 2 208315193 208315373 181 + 1.336 0.844 -1.789
ENSG00000115020 E026 19.7566645 0.0008959306 6.641111e-04 2.767433e-03 2 208317867 208317941 75 + 1.157 0.844 -1.159
ENSG00000115020 E027 24.0718270 0.0008175255 1.274252e-03 4.891460e-03 2 208320252 208320359 108 + 1.231 0.999 -0.834
ENSG00000115020 E028 25.1939351 0.0009995956 5.554672e-05 3.093955e-04 2 208324142 208324282 141 + 1.257 0.902 -1.290
ENSG00000115020 E029 26.5728703 0.0009376984 2.563163e-04 1.201502e-03 2 208324911 208325037 127 + 1.275 0.999 -0.988
ENSG00000115020 E030 114.0227808 0.0090003736 9.319464e-05 4.900615e-04 2 208325270 208326429 1160 + 1.875 1.766 -0.367
ENSG00000115020 E031 21.7394858 0.0009599469 1.317299e-02 3.631366e-02 2 208328180 208328280 101 + 1.182 1.041 -0.510
ENSG00000115020 E032 18.3359031 0.0009477627 1.406933e-01 2.489671e-01 2 208329842 208329913 72 + 1.103 1.078 -0.088
ENSG00000115020 E033 27.0080842 0.0007190774 6.662582e-02 1.377744e-01 2 208330523 208330694 172 + 1.260 1.230 -0.106
ENSG00000115020 E034 26.5086878 0.0009148452 4.585314e-02 1.017671e-01 2 208333315 208333493 179 + 1.255 1.203 -0.181
ENSG00000115020 E035 0.2924217 0.0293738511 1.000000e+00   2 208334372 208334503 132 + 0.084 0.000 -17.201
ENSG00000115020 E036 24.4388711 0.0013658563 2.748637e-03 9.517037e-03 2 208335306 208335419 114 + 1.236 1.041 -0.701
ENSG00000115020 E037 23.9636122 0.0008310450 3.388140e-03 1.140317e-02 2 208335793 208335901 109 + 1.228 1.041 -0.673
ENSG00000115020 E038 31.0869092 0.0006599263 1.011757e-01 1.922665e-01 2 208336046 208336200 155 + 1.317 1.321 0.017
ENSG00000115020 E039 21.0162717 0.0008882985 8.908212e-01 9.342630e-01 2 208336838 208336928 91 + 1.138 1.278 0.497
ENSG00000115020 E040 21.0305315 0.0009158693 1.392840e-01 2.470733e-01 2 208338508 208338568 61 + 1.157 1.145 -0.043
ENSG00000115020 E041 33.2955544 0.0005850675 5.056484e-01 6.413895e-01 2 208339418 208339555 138 + 1.330 1.431 0.350
ENSG00000115020 E042 33.1884366 0.0024575254 6.947426e-01 7.954942e-01 2 208340011 208340131 121 + 1.323 1.447 0.428
ENSG00000115020 E043 28.7384626 0.0007383498 2.350723e-01 3.684353e-01 2 208342554 208342649 96 + 1.277 1.322 0.155
ENSG00000115020 E044 29.5060572 0.0007342162 1.147553e-01 2.124723e-01 2 208345111 208345194 84 + 1.294 1.300 0.022
ENSG00000115020 E045 33.8783126 0.0034727502 4.328325e-01 5.752931e-01 2 208346050 208346147 98 + 1.343 1.430 0.304
ENSG00000115020 E046 44.8494160 0.0020281382 5.268249e-01 6.600100e-01 2 208347859 208348023 165 + 1.456 1.567 0.381
ENSG00000115020 E047 31.5415161 0.0006567684 8.455237e-01 9.039328e-01 2 208350024 208350083 60 + 1.305 1.446 0.489
ENSG00000115020 E048 42.6966993 0.0006400494 6.624039e-01 7.707169e-01 2 208350771 208350947 177 + 1.421 1.612 0.655
ENSG00000115020 E049 24.6192035 0.0008515804 4.098281e-01 5.534577e-01 2 208351352 208351455 104 + 1.182 1.414 0.812
ENSG00000115020 E050 34.0750207 0.0087221168 6.520890e-02 1.353808e-01 2 208352654 208352782 129 + 1.353 1.324 -0.103
ENSG00000115020 E051 55.5449174 0.0023904080 3.568806e-04 1.606853e-03 2 208353898 208354159 262 + 1.570 1.447 -0.425
ENSG00000115020 E052 28.9073442 0.0007123646 8.838248e-02 1.726486e-01 2 208354571 208354645 75 + 1.287 1.278 -0.031
ENSG00000115020 E053 430.9532614 0.0177498101 5.251277e-16 2.058003e-14 2 208355190 208358746 3557 + 2.330 2.875 1.817