ENSG00000114993

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000233330 ENSG00000114993 HEK293_OSMI2_2hA HEK293_TMG_2hB RTKN protein_coding protein_coding 21.22952 32.55192 12.91177 1.376558 0.4226291 -1.333382 3.8126415 6.2244414 2.4544763 0.55474803 0.51847574 -1.3389792 0.18332083 0.191300000 0.18796667 -0.003333333 9.816572e-01 3.374234e-08 FALSE TRUE
ENST00000272430 ENSG00000114993 HEK293_OSMI2_2hA HEK293_TMG_2hB RTKN protein_coding protein_coding 21.22952 32.55192 12.91177 1.376558 0.4226291 -1.333382 8.4057935 15.9867390 3.0003521 0.70162411 0.25036814 -2.4097737 0.35255833 0.491366667 0.23353333 -0.257833333 3.374234e-08 3.374234e-08 FALSE TRUE
ENST00000305557 ENSG00000114993 HEK293_OSMI2_2hA HEK293_TMG_2hB RTKN protein_coding protein_coding 21.22952 32.55192 12.91177 1.376558 0.4226291 -1.333382 1.0414131 1.3795178 1.0527577 0.11952442 0.15577464 -0.3867717 0.05558333 0.042266667 0.08240000 0.040133333 5.155774e-02 3.374234e-08 FALSE TRUE
ENST00000469859 ENSG00000114993 HEK293_OSMI2_2hA HEK293_TMG_2hB RTKN protein_coding retained_intron 21.22952 32.55192 12.91177 1.376558 0.4226291 -1.333382 1.1622291 0.7959696 1.0108434 0.09093233 0.15982146 0.3409643 0.06537917 0.024333333 0.07810000 0.053766667 7.058179e-05 3.374234e-08   FALSE
ENST00000472518 ENSG00000114993 HEK293_OSMI2_2hA HEK293_TMG_2hB RTKN protein_coding retained_intron 21.22952 32.55192 12.91177 1.376558 0.4226291 -1.333382 0.7138689 0.3017574 0.9734238 0.10149892 0.06337358 1.6573894 0.04336667 0.009366667 0.07530000 0.065933333 1.157724e-07 3.374234e-08 FALSE FALSE
ENST00000492013 ENSG00000114993 HEK293_OSMI2_2hA HEK293_TMG_2hB RTKN protein_coding retained_intron 21.22952 32.55192 12.91177 1.376558 0.4226291 -1.333382 2.5029979 2.5337784 2.3894728 0.20856967 0.11149862 -0.0842555 0.13248333 0.077833333 0.18570000 0.107866667 1.468985e-06 3.374234e-08 FALSE FALSE
ENST00000640304 ENSG00000114993 HEK293_OSMI2_2hA HEK293_TMG_2hB RTKN protein_coding protein_coding 21.22952 32.55192 12.91177 1.376558 0.4226291 -1.333382 1.8336107 2.8310673 0.9184900 0.06079448 0.18063790 -1.6134748 0.08881667 0.087400000 0.07176667 -0.015633333 6.981227e-01 3.374234e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114993 E001 5.266020 0.0030777950 6.278515e-01 7.435332e-01 2 74425835 74425835 1 - 0.768 0.699 -0.282
ENSG00000114993 E002 12.087166 0.0015656081 7.105988e-01 8.077281e-01 2 74425836 74425882 47 - 1.055 1.017 -0.138
ENSG00000114993 E003 219.796043 0.0026926678 8.009228e-04 3.262993e-03 2 74425883 74426179 297 - 2.128 2.264 0.453
ENSG00000114993 E004 228.846012 0.0015177366 3.580005e-07 3.260209e-06 2 74426180 74426405 226 - 2.102 2.287 0.620
ENSG00000114993 E005 182.159900 0.0030362365 6.185349e-04 2.601563e-03 2 74426406 74426574 169 - 2.031 2.184 0.513
ENSG00000114993 E006 22.811016 0.0008988485 1.377526e-01 2.449462e-01 2 74426575 74426759 185 - 1.371 1.252 -0.415
ENSG00000114993 E007 180.134835 0.0007088629 1.164023e-01 2.148236e-01 2 74427169 74427273 105 - 2.106 2.164 0.195
ENSG00000114993 E008 229.329065 0.0013111909 6.511170e-01 7.620729e-01 2 74427424 74427592 169 - 2.238 2.258 0.066
ENSG00000114993 E009 31.012826 0.0006692651 1.383845e-17 6.672569e-16 2 74427593 74428002 410 - 1.774 1.235 -1.851
ENSG00000114993 E010 175.035172 0.0002060403 9.672564e-01 9.834899e-01 2 74428268 74428396 129 - 2.134 2.139 0.018
ENSG00000114993 E011 150.384855 0.0003182326 5.597466e-01 6.878182e-01 2 74428631 74428737 107 - 2.089 2.072 -0.055
ENSG00000114993 E012 145.222650 0.0035540620 1.449387e-01 2.547544e-01 2 74428848 74428942 95 - 2.106 2.049 -0.190
ENSG00000114993 E013 194.449051 0.0002659377 1.523487e-01 2.648814e-01 2 74429828 74430027 200 - 2.217 2.177 -0.131
ENSG00000114993 E014 77.351590 0.0003465721 7.451883e-01 8.333150e-01 2 74430028 74430037 10 - 1.796 1.783 -0.041
ENSG00000114993 E015 73.684647 0.0003590436 4.827673e-01 6.208848e-01 2 74430252 74430254 3 - 1.791 1.760 -0.104
ENSG00000114993 E016 136.040386 0.0002650347 7.671275e-01 8.494261e-01 2 74430255 74430369 115 - 2.016 2.031 0.050
ENSG00000114993 E017 96.937412 0.0003335063 8.124013e-01 8.810090e-01 2 74430465 74430518 54 - 1.887 1.880 -0.022
ENSG00000114993 E018 81.204203 0.0080304428 3.736610e-01 5.180691e-01 2 74430616 74430677 62 - 1.751 1.818 0.226
ENSG00000114993 E019 8.081017 0.0022009844 1.263290e-05 8.200886e-05 2 74430678 74430929 252 - 1.210 0.714 -1.864
ENSG00000114993 E020 9.557074 0.0018177739 6.326043e-15 2.147760e-13 2 74431755 74432058 304 - 1.424 0.616 -3.027
ENSG00000114993 E021 9.742028 0.0093126079 5.723344e-15 1.951569e-13 2 74432059 74432466 408 - 1.453 0.598 -3.208
ENSG00000114993 E022 51.463500 0.0202744361 8.426486e-01 9.019563e-01 2 74432467 74432471 5 - 1.614 1.611 -0.011
ENSG00000114993 E023 105.352323 0.0085547649 7.750507e-01 8.550558e-01 2 74432472 74432560 89 - 1.923 1.917 -0.022
ENSG00000114993 E024 69.654382 0.0032953791 9.718739e-01 9.864324e-01 2 74432561 74432576 16 - 1.732 1.739 0.026
ENSG00000114993 E025 136.085913 0.0025070233 6.201105e-01 7.373903e-01 2 74432577 74432666 90 - 2.041 2.025 -0.054
ENSG00000114993 E026 20.580624 0.0009212254 2.038687e-06 1.583076e-05 2 74439551 74439977 427 - 1.505 1.132 -1.307
ENSG00000114993 E027 1.431828 0.0122102880 3.207258e-02 7.599722e-02 2 74439978 74440197 220 - 0.607 0.229 -2.127
ENSG00000114993 E028 21.278749 0.0008709802 2.642547e-05 1.592869e-04 2 74440353 74440631 279 - 1.489 1.159 -1.153
ENSG00000114993 E029 136.061252 0.0017930460 3.584365e-01 5.028415e-01 2 74441706 74442199 494 - 1.993 2.036 0.145
ENSG00000114993 E030 20.332257 0.0126917244 3.762177e-01 5.205699e-01 2 74442200 74442422 223 - 1.139 1.239 0.354