ENSG00000114988

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264963 ENSG00000114988 HEK293_OSMI2_2hA HEK293_TMG_2hB LMAN2L protein_coding protein_coding 29.17825 31.70845 24.00015 1.665831 0.564636 -0.4016776 27.52576 31.04978 21.83555 1.637795 0.2685305 -0.5077082 0.9426458 0.9792333 0.9103333 -0.0689 8.830372e-09 8.830372e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114988 E001 31.3846770 0.0141149659 2.238095e-03 7.960459e-03 2 96705929 96705974 46 - 1.291 1.578 0.992
ENSG00000114988 E002 378.5616040 0.0036457965 3.072290e-04 1.408845e-03 2 96705975 96706339 365 - 2.475 2.600 0.416
ENSG00000114988 E003 607.8282913 0.0005728700 1.151836e-05 7.545885e-05 2 96706340 96706876 537 - 2.712 2.794 0.271
ENSG00000114988 E004 281.4363597 0.0001804087 2.609763e-02 6.414366e-02 2 96706877 96707043 167 - 2.397 2.454 0.189
ENSG00000114988 E005 185.8415160 0.0002028828 9.365525e-01 9.640982e-01 2 96707044 96707116 73 - 2.247 2.257 0.035
ENSG00000114988 E006 174.5592390 0.0002063578 9.091829e-01 9.463117e-01 2 96707117 96707179 63 - 2.225 2.230 0.018
ENSG00000114988 E007 285.1980996 0.0001637718 9.386854e-01 9.655028e-01 2 96707180 96707398 219 - 2.433 2.443 0.033
ENSG00000114988 E008 0.8783198 0.0137090719 3.656797e-01 5.099875e-01 2 96707678 96707713 36 - 0.147 0.312 1.384
ENSG00000114988 E009 171.4279577 0.0002491800 4.258670e-01 5.687483e-01 2 96707714 96707833 120 - 2.200 2.231 0.102
ENSG00000114988 E010 155.5032962 0.0002667205 9.715879e-01 9.862425e-01 2 96711656 96711725 70 - 2.170 2.179 0.031
ENSG00000114988 E011 143.2959696 0.0012757828 5.430266e-01 6.736937e-01 2 96711726 96711770 45 - 2.147 2.133 -0.048
ENSG00000114988 E012 243.7723783 0.0030759636 3.751206e-01 5.195338e-01 2 96711864 96712025 162 - 2.384 2.358 -0.087
ENSG00000114988 E013 0.9933036 0.0126473843 5.923506e-01 7.149030e-01 2 96713107 96713139 33 - 0.344 0.253 -0.614
ENSG00000114988 E014 179.0767588 0.0008131486 1.333744e-02 3.670656e-02 2 96733519 96733601 83 - 2.277 2.212 -0.217
ENSG00000114988 E015 202.6251792 0.0002436602 1.706961e-06 1.348198e-05 2 96734409 96734526 118 - 2.361 2.250 -0.373
ENSG00000114988 E016 2.4691272 0.0119250074 3.684613e-02 8.517760e-02 2 96734527 96734687 161 - 0.701 0.365 -1.611
ENSG00000114988 E017 4.7598120 0.0034140201 7.454694e-04 3.062495e-03 2 96737137 96737217 81 - 0.976 0.527 -1.836
ENSG00000114988 E018 182.7483499 0.0009388466 2.122915e-06 1.641740e-05 2 96737949 96738067 119 - 2.326 2.196 -0.435
ENSG00000114988 E019 162.2972926 0.0012058864 1.109274e-09 1.631335e-08 2 96739854 96740064 211 - 2.304 2.120 -0.615