ENSG00000114978

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396049 ENSG00000114978 HEK293_OSMI2_2hA HEK293_TMG_2hB MOB1A protein_coding protein_coding 28.24556 9.720202 52.85901 2.514639 0.6500406 2.441881 21.251099 8.97403 39.54053 2.411676 1.674527 2.138262 0.80223750 0.9176 0.7476 -0.1700 5.528745e-05 1.2356e-19 FALSE TRUE
ENST00000497054 ENSG00000114978 HEK293_OSMI2_2hA HEK293_TMG_2hB MOB1A protein_coding processed_transcript 28.24556 9.720202 52.85901 2.514639 0.6500406 2.441881 4.728528 0.00000 10.17529 0.000000 1.232393 9.992271 0.09615833 0.0000 0.1928 0.1928 1.235600e-19 1.2356e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114978 E001 2.8126643 0.1448917714 3.255923e-03 1.101965e-02 2 74152528 74152601 74 - 0.262 0.951 3.259
ENSG00000114978 E002 86.0556099 0.0003711604 1.329220e-49 7.844760e-47 2 74152602 74152779 178 - 1.654 2.245 1.984
ENSG00000114978 E003 77.8894503 0.0005483283 3.148742e-43 1.322660e-40 2 74152780 74152799 20 - 1.616 2.199 1.964
ENSG00000114978 E004 144.5800167 0.0003147876 7.108873e-61 7.523769e-58 2 74152800 74152881 82 - 1.917 2.433 1.726
ENSG00000114978 E005 2296.9388219 0.0003609159 2.807269e-07 2.613409e-06 2 74152882 74156417 3536 - 3.284 3.332 0.160
ENSG00000114978 E006 312.8872901 0.0001518999 8.518908e-05 4.525747e-04 2 74156418 74156645 228 - 2.451 2.370 -0.270
ENSG00000114978 E007 5.8948556 0.0188619811 7.824698e-01 8.603298e-01 2 74158654 74158771 118 - 0.776 0.827 0.201
ENSG00000114978 E008 0.2966881 0.0271987348 1.000000e+00   2 74159069 74159090 22 - 0.124 0.000 -8.288
ENSG00000114978 E009 115.4406532 0.0003694371 2.219542e-04 1.057772e-03 2 74159091 74159108 18 - 2.032 1.893 -0.467
ENSG00000114978 E010 280.8143452 0.0001833856 1.086797e-08 1.330815e-07 2 74159109 74159254 146 - 2.414 2.277 -0.458
ENSG00000114978 E011 0.7770552 0.0147586943 6.327297e-02 1.321625e-01 2 74164022 74165217 1196 - 0.124 0.464 2.527
ENSG00000114978 E012 273.0704070 0.0001800899 7.409987e-13 1.856387e-11 2 74165218 74165351 134 - 2.409 2.226 -0.612
ENSG00000114978 E013 218.3846784 0.0015181505 1.312526e-08 1.583280e-07 2 74167014 74167107 94 - 2.315 2.117 -0.663
ENSG00000114978 E014 235.2738601 0.0007298876 4.016571e-14 1.208205e-12 2 74172586 74172675 90 - 2.353 2.115 -0.795
ENSG00000114978 E015 200.2939849 0.0001911149 1.010549e-13 2.871107e-12 2 74172676 74172749 74 - 2.282 2.052 -0.772
ENSG00000114978 E016 85.1857219 0.0003906635 1.517845e-06 1.212273e-05 2 74172750 74172752 3 - 1.913 1.683 -0.775
ENSG00000114978 E017 2.5956625 0.0064779453 4.683408e-02 1.035355e-01 2 74178008 74178114 107 - 0.397 0.738 1.581
ENSG00000114978 E018 3.8907518 0.0043756596 3.714815e-02 8.576171e-02 2 74178115 74178281 167 - 0.543 0.868 1.357
ENSG00000114978 E019 0.4481018 0.0248914568 9.291331e-02 1.796834e-01 2 74178282 74178314 33 - 0.067 0.357 2.939
ENSG00000114978 E020 176.1046695 0.0004399000 7.336853e-09 9.266299e-08 2 74178661 74178898 238 - 2.220 2.029 -0.641