ENSG00000114956

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264093 ENSG00000114956 HEK293_OSMI2_2hA HEK293_TMG_2hB DGUOK protein_coding protein_coding 135.2942 227.5875 92.4314 4.268211 2.026287 -1.299874 14.98293 24.15252 16.61683 1.203669 1.3795696 -0.5392579 0.1184917 0.1060667 0.1798000 0.07373333 0.000450032 0.000450032 FALSE  
ENST00000418996 ENSG00000114956 HEK293_OSMI2_2hA HEK293_TMG_2hB DGUOK protein_coding nonsense_mediated_decay 135.2942 227.5875 92.4314 4.268211 2.026287 -1.299874 52.62208 90.88573 31.40648 1.874816 1.4044359 -1.5326911 0.3810792 0.3993333 0.3394667 -0.05986667 0.003875210 0.000450032    
ENST00000629438 ENSG00000114956 HEK293_OSMI2_2hA HEK293_TMG_2hB DGUOK protein_coding protein_coding 135.2942 227.5875 92.4314 4.268211 2.026287 -1.299874 29.14937 44.40403 20.89652 2.681130 0.9093205 -1.0870629 0.2205333 0.1949667 0.2260000 0.03103333 0.304098747 0.000450032 FALSE  
MSTRG.18676.5 ENSG00000114956 HEK293_OSMI2_2hA HEK293_TMG_2hB DGUOK protein_coding   135.2942 227.5875 92.4314 4.268211 2.026287 -1.299874 19.23989 36.33647 9.54920 1.536021 0.4894799 -1.9268537 0.1351333 0.1600333 0.1035333 -0.05650000 0.005390765 0.000450032    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114956 E001 2.175598 0.0960790960 4.685397e-01 6.079522e-01 2 73926820 73926825 6 + 0.555 0.422 -0.654
ENSG00000114956 E002 2.544292 0.0584296861 3.681399e-01 5.125411e-01 2 73926826 73926827 2 + 0.613 0.456 -0.741
ENSG00000114956 E003 3.288038 0.0186438062 4.626459e-02 1.025217e-01 2 73926828 73926829 2 + 0.790 0.485 -1.331
ENSG00000114956 E004 4.549828 0.0950438507 7.327543e-02 1.487565e-01 2 73926830 73926830 1 + 0.916 0.587 -1.342
ENSG00000114956 E005 28.661372 0.0041361044 1.023158e-01 1.940458e-01 2 73926831 73926874 44 + 1.491 1.383 -0.370
ENSG00000114956 E006 36.336702 0.0014637894 1.015917e-01 1.929119e-01 2 73926875 73926879 5 + 1.576 1.485 -0.310
ENSG00000114956 E007 93.724025 0.0052196398 1.048996e-03 4.129000e-03 2 73926880 73926892 13 + 2.022 1.865 -0.527
ENSG00000114956 E008 97.648940 0.0046412414 3.018781e-04 1.387128e-03 2 73926893 73926893 1 + 2.047 1.880 -0.562
ENSG00000114956 E009 130.232680 0.0056671096 1.803422e-02 4.720657e-02 2 73926894 73926896 3 + 2.127 2.024 -0.347
ENSG00000114956 E010 271.713154 0.0023204693 8.196905e-02 1.626358e-01 2 73926897 73926907 11 + 2.403 2.360 -0.144
ENSG00000114956 E011 942.944702 0.0015004202 3.610491e-02 8.379026e-02 2 73926908 73927052 145 + 2.867 2.924 0.192
ENSG00000114956 E012 16.237439 0.0011394682 4.136494e-01 5.570956e-01 2 73932598 73932683 86 + 1.110 1.203 0.335
ENSG00000114956 E013 183.454588 0.0005444013 1.615705e-07 1.577054e-06 2 73938910 73939022 113 + 2.304 2.164 -0.468
ENSG00000114956 E014 5.354526 0.0439455183 9.457297e-01 9.699461e-01 2 73943172 73943275 104 + 0.751 0.756 0.018
ENSG00000114956 E015 1179.936506 0.0002982229 5.910193e-01 7.138238e-01 2 73946719 73946888 170 + 3.003 3.011 0.026
ENSG00000114956 E016 510.766728 0.0001154713 1.234464e-01 2.248643e-01 2 73946889 73946906 18 + 2.614 2.658 0.145
ENSG00000114956 E017 5.213212 0.0031687052 8.351519e-07 7.055071e-06 2 73946907 73947131 225 + 1.110 0.485 -2.533
ENSG00000114956 E018 243.243134 0.0001831634 2.515601e-01 3.878172e-01 2 73950585 73950600 16 + 2.336 2.322 -0.046
ENSG00000114956 E019 264.657200 0.0001675487 1.626786e-01 2.786500e-01 2 73950601 73950626 26 + 2.376 2.358 -0.061
ENSG00000114956 E020 492.862629 0.0001427105 1.791696e-05 1.123573e-04 2 73950627 73950732 106 + 2.677 2.617 -0.200
ENSG00000114956 E021 545.028467 0.0001444000 1.616452e-03 6.013273e-03 2 73957125 73957240 116 + 2.704 2.666 -0.126
ENSG00000114956 E022 1208.662180 0.0006332186 1.103936e-04 5.698098e-04 2 73958146 73958245 100 + 2.963 3.037 0.247
ENSG00000114956 E023 1195.740940 0.0024904972 1.519418e-03 5.699308e-03 2 73958710 73958961 252 + 2.944 3.036 0.307