ENSG00000114857

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000232978 ENSG00000114857 HEK293_OSMI2_2hA HEK293_TMG_2hB NKTR protein_coding protein_coding 16.10176 5.072045 25.26404 0.8047622 0.710579 2.314176 2.918218 0.94210174 4.5212078 0.32214576 0.32601254 2.250708 0.21484583 0.19940000 0.17900000 -0.02040000 1.000000e+00 1.956167e-12 FALSE TRUE
ENST00000429888 ENSG00000114857 HEK293_OSMI2_2hA HEK293_TMG_2hB NKTR protein_coding nonsense_mediated_decay 16.10176 5.072045 25.26404 0.8047622 0.710579 2.314176 1.492921 0.19561119 2.3157765 0.19561119 0.17341441 3.499722 0.08110417 0.02936667 0.09170000 0.06233333 2.326456e-01 1.956167e-12 FALSE TRUE
ENST00000460807 ENSG00000114857 HEK293_OSMI2_2hA HEK293_TMG_2hB NKTR protein_coding retained_intron 16.10176 5.072045 25.26404 0.8047622 0.710579 2.314176 1.480577 0.08696334 3.0412114 0.08696334 0.41482658 4.975799 0.06503333 0.01943333 0.11983333 0.10040000 7.653179e-02 1.956167e-12 FALSE TRUE
ENST00000472127 ENSG00000114857 HEK293_OSMI2_2hA HEK293_TMG_2hB NKTR protein_coding retained_intron 16.10176 5.072045 25.26404 0.8047622 0.710579 2.314176 1.484221 0.11066178 2.6385073 0.01515118 0.24338160 4.456139 0.07421250 0.02280000 0.10410000 0.08130000 1.209822e-05 1.956167e-12   FALSE
ENST00000490189 ENSG00000114857 HEK293_OSMI2_2hA HEK293_TMG_2hB NKTR protein_coding retained_intron 16.10176 5.072045 25.26404 0.8047622 0.710579 2.314176 0.830685 2.07058508 0.3429284 0.42472941 0.06686713 -2.559542 0.12731250 0.41776667 0.01346667 -0.40430000 1.956167e-12 1.956167e-12   FALSE
MSTRG.22813.8 ENSG00000114857 HEK293_OSMI2_2hA HEK293_TMG_2hB NKTR protein_coding   16.10176 5.072045 25.26404 0.8047622 0.710579 2.314176 4.645535 0.93257684 7.5648943 0.29548198 0.06786110 3.006544 0.25858333 0.17540000 0.29993333 0.12453333 1.577088e-02 1.956167e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114857 E001 0.0000000       3 42600067 42600083 17 +      
ENSG00000114857 E002 0.4375944 0.0276012953 1.000000e+00 1.000000e+00 3 42600084 42600586 503 + 0.132 0.000 -9.734
ENSG00000114857 E003 0.2924217 0.0295287182 1.000000e+00   3 42600587 42600597 11 + 0.092 0.000 -10.907
ENSG00000114857 E004 0.7363589 0.0156190560 4.503426e-01 5.914402e-01 3 42600598 42600654 57 + 0.202 0.000 -12.296
ENSG00000114857 E005 0.7342825 0.0174225422 4.509303e-01 5.919498e-01 3 42600655 42600659 5 + 0.202 0.000 -12.281
ENSG00000114857 E006 1.9293403 0.0075136679 7.336997e-02 1.489149e-01 3 42600660 42600671 12 + 0.405 0.000 -13.616
ENSG00000114857 E007 4.0694150 0.0056671886 5.239870e-01 6.576159e-01 3 42600672 42600681 10 + 0.585 0.566 -0.087
ENSG00000114857 E008 4.6669438 0.0123298585 3.634383e-01 5.078426e-01 3 42600682 42600685 4 + 0.636 0.566 -0.311
ENSG00000114857 E009 16.5116508 0.0017687262 4.778560e-01 6.163509e-01 3 42600686 42600717 32 + 1.084 1.131 0.166
ENSG00000114857 E010 18.4870852 0.0019151974 7.088024e-01 8.063684e-01 3 42600718 42600742 25 + 1.121 1.209 0.315
ENSG00000114857 E011 21.7345193 0.0008820245 3.586919e-01 5.030619e-01 3 42600743 42600760 18 + 1.196 1.232 0.129
ENSG00000114857 E012 20.7360455 0.0008602153 1.334386e-01 2.389145e-01 3 42600761 42600778 18 + 1.189 1.158 -0.111
ENSG00000114857 E013 0.8856842 0.0657655292 3.633066e-01 5.077201e-01 3 42600779 42600979 201 + 0.233 0.000 -12.216
ENSG00000114857 E014 0.5911862 0.0184234977 6.090321e-01 7.285933e-01 3 42600980 42600983 4 + 0.169 0.000 -11.967
ENSG00000114857 E015 34.7181225 0.0005911763 5.649794e-01 6.921696e-01 3 42600984 42601064 81 + 1.385 1.471 0.298
ENSG00000114857 E016 2.4305312 0.1314458503 5.940086e-02 1.256096e-01 3 42601065 42603056 1992 + 0.315 0.805 2.338
ENSG00000114857 E017 0.0000000       3 42611103 42611184 82 +      
ENSG00000114857 E018 37.7530795 0.0005886810 6.985206e-01 7.984689e-01 3 42617570 42617644 75 + 1.417 1.520 0.355
ENSG00000114857 E019 47.6620783 0.0011593365 6.358845e-01 7.500554e-01 3 42619020 42619127 108 + 1.514 1.615 0.345
ENSG00000114857 E020 8.7662142 0.0174821064 6.529404e-04 2.726178e-03 3 42619128 42619663 536 + 0.897 0.277 -2.948
ENSG00000114857 E021 38.0032207 0.0005821880 2.561893e-01 3.931557e-01 3 42619664 42619708 45 + 1.427 1.471 0.152
ENSG00000114857 E022 5.8666078 0.0236021149 4.204158e-01 5.636203e-01 3 42619709 42619818 110 + 0.702 0.661 -0.171
ENSG00000114857 E023 6.4265859 0.0561297019 3.581776e-01 5.025488e-01 3 42619819 42620015 197 + 0.742 0.662 -0.331
ENSG00000114857 E024 12.4824863 0.0013984194 5.959546e-02 1.259325e-01 3 42620016 42620043 28 + 1.001 0.860 -0.528
ENSG00000114857 E025 25.1068886 0.0028450075 2.103059e-05 1.297821e-04 3 42620044 42621004 961 + 1.301 0.911 -1.410
ENSG00000114857 E026 10.8101569 0.0015497638 2.344074e-03 8.289055e-03 3 42621005 42621428 424 + 0.963 0.566 -1.610
ENSG00000114857 E027 41.8459005 0.0005864822 3.478843e-05 2.034941e-04 3 42621429 42621516 88 + 1.500 1.276 -0.776
ENSG00000114857 E028 2.2365358 0.0495492922 8.416096e-01 9.012013e-01 3 42627186 42627199 14 + 0.406 0.443 0.202
ENSG00000114857 E029 8.6332569 0.0028626587 2.899974e-01 4.307587e-01 3 42627200 42627227 28 + 0.848 0.803 -0.175
ENSG00000114857 E030 148.1041119 0.0054526005 2.088804e-14 6.557044e-13 3 42627228 42630545 3318 + 2.047 1.702 -1.162
ENSG00000114857 E031 29.6418527 0.0006502737 2.089822e-02 5.337520e-02 3 42630546 42630575 30 + 1.340 1.255 -0.298
ENSG00000114857 E032 7.9585000 0.0020667966 6.437758e-03 1.976011e-02 3 42630576 42631032 457 + 0.848 0.445 -1.759
ENSG00000114857 E033 3.1795661 0.0049329496 1.247369e-01 2.267636e-01 3 42631033 42631170 138 + 0.528 0.277 -1.408
ENSG00000114857 E034 53.0489653 0.0006152843 2.519831e-06 1.918014e-05 3 42631171 42631316 146 + 1.600 1.368 -0.796
ENSG00000114857 E035 89.8343098 0.0240860874 2.082580e-03 7.479828e-03 3 42632601 42632823 223 + 1.815 1.668 -0.497
ENSG00000114857 E036 14.5863465 0.0011843115 1.585702e-03 5.912466e-03 3 42632824 42633112 289 + 1.076 0.738 -1.289
ENSG00000114857 E037 18.8126085 0.0010693564 3.134843e-01 4.560885e-01 3 42633209 42633579 371 + 1.140 1.158 0.065
ENSG00000114857 E038 44.3222930 0.0055026597 2.306644e-02 5.788902e-02 3 42633580 42633636 57 + 1.505 1.445 -0.206
ENSG00000114857 E039 70.7751909 0.0003273434 1.402358e-04 7.046082e-04 3 42633637 42633735 99 + 1.709 1.605 -0.352
ENSG00000114857 E040 69.0669372 0.0003454882 3.111005e-06 2.318988e-05 3 42634613 42634700 88 + 1.705 1.532 -0.588
ENSG00000114857 E041 0.2924217 0.0295287182 1.000000e+00   3 42634701 42635057 357 + 0.092 0.000 -10.907
ENSG00000114857 E042 0.0000000       3 42635080 42635220 141 +      
ENSG00000114857 E043 82.6923562 0.0003241446 2.214701e-07 2.105211e-06 3 42635221 42635366 146 + 1.784 1.605 -0.605
ENSG00000114857 E044 0.5933762 0.0232702197 6.107271e-01 7.300126e-01 3 42635367 42635481 115 + 0.169 0.000 -11.927
ENSG00000114857 E045 396.7826984 0.0182725357 2.135399e-05 1.315336e-04 3 42636868 42638226 1359 + 2.454 2.326 -0.427
ENSG00000114857 E046 260.6707091 0.0005318448 1.481395e-06 1.186161e-05 3 42638227 42638906 680 + 2.258 2.240 -0.062
ENSG00000114857 E047 58.6030586 0.0005273591 1.554142e-01 2.689502e-01 3 42638907 42638987 81 + 1.607 1.651 0.149
ENSG00000114857 E048 316.7276589 0.0001953041 1.414114e-01 2.499716e-01 3 42638988 42639750 763 + 2.323 2.421 0.328
ENSG00000114857 E049 106.0396238 0.0003117770 9.040205e-01 9.429287e-01 3 42642501 42642596 96 + 1.847 1.977 0.438
ENSG00000114857 E050 80.1347181 0.0018681231 5.534600e-01 6.826036e-01 3 42643339 42643395 57 + 1.731 1.833 0.347
ENSG00000114857 E051 6.9255773 0.0027739275 4.095469e-01 5.531562e-01 3 42643652 42643898 247 + 0.759 0.738 -0.086
ENSG00000114857 E052 25.5926082 0.0007609943 2.074296e-01 3.354210e-01 3 42643899 42643901 3 + 1.266 1.276 0.036
ENSG00000114857 E053 90.1686081 0.0003342012 1.172724e-01 2.160513e-01 3 42643902 42644003 102 + 1.789 1.844 0.186
ENSG00000114857 E054 885.0716443 0.0172752140 3.782612e-14 1.141817e-12 3 42645888 42649847 3960 + 2.678 3.162 1.609