ENSG00000114850

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265044 ENSG00000114850 HEK293_OSMI2_2hA HEK293_TMG_2hB SSR3 protein_coding protein_coding 162.5537 147.9219 231.8144 7.004765 3.896057 0.6480992 45.409614 20.15569 83.979651 7.108040 3.872158 2.0583091 0.23797500 0.1326333 0.36190000 0.22926667 0.002126559 0.0009172464 FALSE TRUE
ENST00000467789 ENSG00000114850 HEK293_OSMI2_2hA HEK293_TMG_2hB SSR3 protein_coding protein_coding 162.5537 147.9219 231.8144 7.004765 3.896057 0.6480992 32.966114 18.87482 56.934619 2.163880 4.078727 1.5923322 0.18665000 0.1294333 0.24553333 0.11610000 0.012349358 0.0009172464 FALSE TRUE
ENST00000476217 ENSG00000114850 HEK293_OSMI2_2hA HEK293_TMG_2hB SSR3 protein_coding protein_coding 162.5537 147.9219 231.8144 7.004765 3.896057 0.6480992 51.166800 54.25525 63.608899 1.030778 3.480869 0.2294268 0.33843333 0.3690000 0.27466667 -0.09433333 0.070303718 0.0009172464 FALSE TRUE
ENST00000496050 ENSG00000114850 HEK293_OSMI2_2hA HEK293_TMG_2hB SSR3 protein_coding protein_coding 162.5537 147.9219 231.8144 7.004765 3.896057 0.6480992 9.401858 20.36272 5.763778 2.286250 3.959804 -1.8190510 0.06878333 0.1381667 0.02466667 -0.11350000 0.327059623 0.0009172464 FALSE TRUE
ENST00000498205 ENSG00000114850 HEK293_OSMI2_2hA HEK293_TMG_2hB SSR3 protein_coding retained_intron 162.5537 147.9219 231.8144 7.004765 3.896057 0.6480992 17.325234 30.36624 10.580041 3.580364 5.306683 -1.5202350 0.13010417 0.2041333 0.04620000 -0.15793333 0.465261214 0.0009172464 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114850 E001 3718.4350088 0.0408552634 8.390011e-04 3.398248e-03 3 156539553 156542820 3268 - 3.637 3.385 -0.838
ENSG00000114850 E002 572.5927250 0.0001094015 6.437622e-65 7.670366e-62 3 156542821 156543003 183 - 2.844 2.527 -1.055
ENSG00000114850 E003 302.7518799 0.0002238106 3.805181e-50 2.340520e-47 3 156543004 156543007 4 - 2.583 2.191 -1.307
ENSG00000114850 E004 484.0354170 0.0009007344 3.233150e-13 8.545069e-12 3 156543008 156543061 54 - 2.738 2.544 -0.647
ENSG00000114850 E005 877.9351270 0.0003252001 3.263591e-04 1.486316e-03 3 156543062 156543140 79 - 2.924 2.950 0.088
ENSG00000114850 E006 686.5012512 0.0004240265 4.280174e-14 1.282002e-12 3 156543141 156543181 41 - 2.787 2.886 0.329
ENSG00000114850 E007 1172.3926666 0.0003968260 1.199927e-34 2.877502e-32 3 156543182 156543269 88 - 3.002 3.140 0.460
ENSG00000114850 E008 31.3433926 0.0007085400 1.004707e-01 1.911818e-01 3 156543954 156544293 340 - 1.542 1.410 -0.455
ENSG00000114850 E009 23.4852091 0.0008070246 8.173468e-03 2.422237e-02 3 156544294 156544307 14 - 1.306 1.474 0.581
ENSG00000114850 E010 1429.2185820 0.0011878218 4.765967e-23 4.242749e-21 3 156544308 156544439 132 - 3.084 3.227 0.474
ENSG00000114850 E011 2.9463884 0.0053111710 9.321172e-01 9.612462e-01 3 156548805 156548865 61 - 0.603 0.573 -0.136
ENSG00000114850 E012 19.7765244 0.0010952591 9.408189e-04 3.757068e-03 3 156548866 156548904 39 - 1.206 1.439 0.815
ENSG00000114850 E013 1467.3748840 0.0029098301 7.901607e-08 8.186240e-07 3 156548905 156549003 99 - 3.114 3.214 0.333
ENSG00000114850 E014 1.9593378 0.0222234425 1.438981e-01 2.533180e-01 3 156549004 156549099 96 - 0.378 0.621 1.191
ENSG00000114850 E015 2.5153522 0.0307741564 5.638957e-01 6.912891e-01 3 156551398 156551516 119 - 0.578 0.452 -0.604
ENSG00000114850 E016 1699.0810058 0.0057402320 1.924868e-03 6.992971e-03 3 156553655 156553781 127 - 3.192 3.257 0.217
ENSG00000114850 E017 0.7792333 0.0306239423 5.543216e-01 6.833258e-01 3 156553993 156554125 133 - 0.285 0.164 -1.019
ENSG00000114850 E018 5.4367473 0.0089392452 8.419304e-01 9.014423e-01 3 156554737 156554956 220 - 0.801 0.811 0.038
ENSG00000114850 E019 1281.2084392 0.0060414648 8.009493e-02 1.597001e-01 3 156554957 156555149 193 - 3.086 3.110 0.080