ENSG00000114812

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325123 ENSG00000114812 HEK293_OSMI2_2hA HEK293_TMG_2hB VIPR1 protein_coding protein_coding 5.248604 6.976105 4.341039 0.3360767 0.1694682 -0.6831285 2.0248929 3.04844551 1.69296815 0.41300980 0.19589139 -0.84474711 0.37097083 0.439533333 0.38770000 -0.05183333 0.785550466 0.005041964 FALSE TRUE
ENST00000439731 ENSG00000114812 HEK293_OSMI2_2hA HEK293_TMG_2hB VIPR1 protein_coding protein_coding 5.248604 6.976105 4.341039 0.3360767 0.1694682 -0.6831285 0.2151368 0.02142497 0.59610588 0.02142497 0.25729906 4.26958674 0.04445833 0.003366667 0.13930000 0.13593333 0.005041964 0.005041964 FALSE FALSE
ENST00000439910 ENSG00000114812 HEK293_OSMI2_2hA HEK293_TMG_2hB VIPR1 protein_coding nonsense_mediated_decay 5.248604 6.976105 4.341039 0.3360767 0.1694682 -0.6831285 0.3452364 0.57512409 0.09933507 0.29426668 0.09933507 -2.41998642 0.06024583 0.082633333 0.02343333 -0.05920000 0.601434486 0.005041964 FALSE TRUE
ENST00000443646 ENSG00000114812 HEK293_OSMI2_2hA HEK293_TMG_2hB VIPR1 protein_coding nonsense_mediated_decay 5.248604 6.976105 4.341039 0.3360767 0.1694682 -0.6831285 0.2176291 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.05890417 0.000000000 0.00000000 0.00000000   0.005041964 FALSE TRUE
ENST00000473575 ENSG00000114812 HEK293_OSMI2_2hA HEK293_TMG_2hB VIPR1 protein_coding processed_transcript 5.248604 6.976105 4.341039 0.3360767 0.1694682 -0.6831285 0.3394706 0.22672736 0.33841253 0.08187597 0.12886198 0.55757003 0.07146250 0.032133333 0.07683333 0.04470000 0.502378024 0.005041964 FALSE TRUE
ENST00000495189 ENSG00000114812 HEK293_OSMI2_2hA HEK293_TMG_2hB VIPR1 protein_coding retained_intron 5.248604 6.976105 4.341039 0.3360767 0.1694682 -0.6831285 0.3140098 0.27018207 0.26161598 0.09292732 0.06709526 -0.04479625 0.06357917 0.038000000 0.05983333 0.02183333 0.638050336 0.005041964 FALSE FALSE
ENST00000498102 ENSG00000114812 HEK293_OSMI2_2hA HEK293_TMG_2hB VIPR1 protein_coding retained_intron 5.248604 6.976105 4.341039 0.3360767 0.1694682 -0.6831285 0.5909624 0.41900573 0.44594531 0.05483732 0.04399848 0.08786387 0.11880000 0.059633333 0.10343333 0.04380000 0.171876115 0.005041964 FALSE FALSE
MSTRG.22792.15 ENSG00000114812 HEK293_OSMI2_2hA HEK293_TMG_2hB VIPR1 protein_coding   5.248604 6.976105 4.341039 0.3360767 0.1694682 -0.6831285 0.8939208 1.76515714 0.31967523 0.17695551 0.23610684 -2.42882935 0.15449167 0.252566667 0.07416667 -0.17840000 0.186730641 0.005041964 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114812 E001 0.0000000       3 42489299 42489479 181 +      
ENSG00000114812 E002 0.0000000       3 42489480 42489482 3 +      
ENSG00000114812 E003 0.0000000       3 42489483 42489493 11 +      
ENSG00000114812 E004 0.0000000       3 42489494 42489678 185 +      
ENSG00000114812 E005 0.0000000       3 42492328 42492530 203 +      
ENSG00000114812 E006 0.0000000       3 42500044 42500416 373 +      
ENSG00000114812 E007 0.0000000       3 42501912 42502229 318 +      
ENSG00000114812 E008 0.5901394 0.2944004655 1.0000000000 1.000000000 3 42502612 42502616 5 + 0.156 0.179 0.241
ENSG00000114812 E009 0.5901394 0.2944004655 1.0000000000 1.000000000 3 42502617 42502622 6 + 0.156 0.179 0.241
ENSG00000114812 E010 3.1795872 0.0766006365 0.0466721522 0.103244970 3 42502623 42502642 20 + 0.791 0.439 -1.567
ENSG00000114812 E011 4.0955741 0.0272938808 0.0029070263 0.009990701 3 42502643 42502663 21 + 0.921 0.474 -1.890
ENSG00000114812 E012 10.0916136 0.0049804307 0.0005562840 0.002370949 3 42502664 42502813 150 + 1.218 0.869 -1.280
ENSG00000114812 E013 0.1472490 0.0425976109 0.2761748350   3 42512751 42512949 199 + 0.156 0.000 -10.552
ENSG00000114812 E014 9.8397760 0.0018814964 0.0036187133 0.012064309 3 42513749 42513798 50 + 1.183 0.896 -1.050
ENSG00000114812 E015 13.7582958 0.0051144688 0.0525693643 0.113733893 3 42513799 42513854 56 + 1.251 1.081 -0.606
ENSG00000114812 E016 23.1004818 0.0181996904 0.2426480331 0.377277026 3 42519223 42519330 108 + 1.415 1.324 -0.316
ENSG00000114812 E017 31.6917560 0.0187476820 0.8149478177 0.882744811 3 42525887 42525993 107 + 1.456 1.498 0.145
ENSG00000114812 E018 12.0953489 0.0025683022 0.2870202057 0.427484056 3 42527393 42527395 3 + 1.002 1.123 0.440
ENSG00000114812 E019 28.8832552 0.0007650533 0.4875672001 0.625232806 3 42527396 42527496 101 + 1.408 1.466 0.200
ENSG00000114812 E020 3.1260905 0.0395907058 0.0100678490 0.028927773 3 42527497 42527652 156 + 0.820 0.396 -1.914
ENSG00000114812 E021 6.0306828 0.0033826844 0.0833160757 0.164759714 3 42527653 42527990 338 + 0.943 0.734 -0.811
ENSG00000114812 E022 32.9262089 0.0007144416 0.3748901908 0.519332402 3 42527991 42528123 133 + 1.456 1.524 0.232
ENSG00000114812 E023 0.1817044 0.0393827891 0.8384773048   3 42529734 42530251 518 + 0.000 0.095 8.651
ENSG00000114812 E024 32.4509822 0.0072065804 0.3289424873 0.472419331 3 42530779 42530912 134 + 1.429 1.514 0.290
ENSG00000114812 E025 16.1575494 0.0178354375 0.0434794811 0.097433845 3 42530913 42530932 20 + 1.021 1.259 0.855
ENSG00000114812 E026 27.3569114 0.0023823003 0.1223182726 0.223251441 3 42531471 42531531 61 + 1.328 1.452 0.430
ENSG00000114812 E027 33.7717684 0.0146062037 0.6398376056 0.753161480 3 42531803 42531869 67 + 1.475 1.525 0.172
ENSG00000114812 E028 41.8399048 0.0005946304 0.0603407341 0.127189059 3 42532242 42532333 92 + 1.517 1.636 0.404
ENSG00000114812 E029 11.1012182 0.0455420162 0.7982353416 0.871208894 3 42532580 42532733 154 + 1.071 1.057 -0.052
ENSG00000114812 E030 25.9233590 0.0008344227 0.0001127375 0.000580469 3 42532866 42534974 2109 + 1.550 1.304 -0.849
ENSG00000114812 E031 32.2659278 0.0007144416 0.6605739772 0.769220772 3 42534975 42535104 130 + 1.500 1.484 -0.055
ENSG00000114812 E032 15.0205089 0.0104577202 0.3129263224 0.455444651 3 42535343 42535384 42 + 1.230 1.140 -0.317
ENSG00000114812 E033 171.3761160 0.0073544817 0.0819001779 0.162541699 3 42536090 42537573 1484 + 2.151 2.232 0.269