ENSG00000114796

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000242810 ENSG00000114796 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL24 protein_coding protein_coding 3.351633 1.239463 4.228857 0.3524783 0.447473 1.762367 1.1249146 0.07073988 1.7962779 0.07073988 0.1927268 4.4835946 0.21896250 0.03663333 0.42876667 0.39213333 0.0003337185 0.0003337185 FALSE TRUE
ENST00000454495 ENSG00000114796 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL24 protein_coding protein_coding 3.351633 1.239463 4.228857 0.3524783 0.447473 1.762367 0.2651585 0.00000000 0.3616599 0.00000000 0.1831117 5.2159113 0.04589167 0.00000000 0.07746667 0.07746667 0.3835069028 0.0003337185 FALSE FALSE
ENST00000454652 ENSG00000114796 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL24 protein_coding protein_coding 3.351633 1.239463 4.228857 0.3524783 0.447473 1.762367 0.3864180 0.25302656 0.4674704 0.12762067 0.2728540 0.8602028 0.22373333 0.28530000 0.12473333 -0.16056667 0.8129609889 0.0003337185 FALSE TRUE
ENST00000468001 ENSG00000114796 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL24 protein_coding protein_coding 3.351633 1.239463 4.228857 0.3524783 0.447473 1.762367 0.1226665 0.18359501 0.0000000 0.09266258 0.0000000 -4.2749698 0.05257500 0.17180000 0.00000000 -0.17180000 0.0617957045 0.0003337185 FALSE FALSE
ENST00000468101 ENSG00000114796 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL24 protein_coding protein_coding 3.351633 1.239463 4.228857 0.3524783 0.447473 1.762367 0.1427565 0.17798262 0.2822709 0.13202229 0.2822709 0.6367068 0.06046667 0.11750000 0.06360000 -0.05390000 0.5564727333 0.0003337185 FALSE FALSE
ENST00000476808 ENSG00000114796 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL24 protein_coding protein_coding 3.351633 1.239463 4.228857 0.3524783 0.447473 1.762367 0.1818076 0.02403433 0.2598413 0.01283874 0.1376606 2.9870486 0.06446667 0.02660000 0.07036667 0.04376667 0.7751154036 0.0003337185 FALSE TRUE
ENST00000481126 ENSG00000114796 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL24 protein_coding retained_intron 3.351633 1.239463 4.228857 0.3524783 0.447473 1.762367 0.2540543 0.41849182 0.0000000 0.21899118 0.0000000 -5.4211958 0.15940833 0.29733333 0.00000000 -0.29733333 0.0232492888 0.0003337185   FALSE
ENST00000482138 ENSG00000114796 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL24 protein_coding protein_coding 3.351633 1.239463 4.228857 0.3524783 0.447473 1.762367 0.2313467 0.00000000 0.4320191 0.00000000 0.2185120 5.4660367 0.03877917 0.00000000 0.09333333 0.09333333 0.3752352320 0.0003337185 FALSE TRUE
ENST00000493074 ENSG00000114796 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL24 protein_coding protein_coding 3.351633 1.239463 4.228857 0.3524783 0.447473 1.762367 0.2233253 0.00000000 0.3768775 0.00000000 0.2142185 5.2738051 0.04625833 0.00000000 0.08916667 0.08916667 0.4249210043 0.0003337185 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114796 E001 0.0000000       3 183635610 183635618 9 +      
ENSG00000114796 E002 0.0000000       3 183635619 183635619 1 +      
ENSG00000114796 E003 0.0000000       3 183635620 183635622 3 +      
ENSG00000114796 E004 0.0000000       3 183635623 183635634 12 +      
ENSG00000114796 E005 0.2966881 0.0272922113 1.000000e+00   3 183635635 183635642 8 + 0.101 0.000 -14.281
ENSG00000114796 E006 7.2818666 0.0325879883 1.637705e-04 8.082574e-04 3 183635643 183635747 105 + 0.645 1.214 2.168
ENSG00000114796 E007 4.0234531 0.0041334701 1.225161e-02 3.413733e-02 3 183635748 183635782 35 + 0.492 0.916 1.785
ENSG00000114796 E008 3.8449710 0.0045579491 9.087873e-02 1.765345e-01 3 183635783 183635793 11 + 0.510 0.822 1.335
ENSG00000114796 E009 5.5680076 0.0194821178 2.870209e-08 3.243573e-07 3 183636221 183636311 91 + 0.433 1.234 3.238
ENSG00000114796 E010 0.9995446 0.0136968632 2.616443e-04 1.223290e-03 3 183636312 183636450 139 + 0.054 0.701 4.935
ENSG00000114796 E011 1.8726410 0.5977804038 2.300424e-02 5.775817e-02 3 183636571 183636682 112 + 0.144 0.852 3.958
ENSG00000114796 E012 0.5879639 0.0221011578 6.071281e-01 7.271787e-01 3 183642907 183643479 573 + 0.144 0.256 1.028
ENSG00000114796 E013 5.1392091 0.0031339635 8.375689e-02 1.654291e-01 3 183643480 183643542 63 + 0.717 0.417 -1.385
ENSG00000114796 E014 0.0000000       3 183644086 183644167 82 +      
ENSG00000114796 E015 8.6641749 0.0123806210 6.301326e-02 1.317290e-01 3 183650296 183650356 61 + 0.901 0.626 -1.108
ENSG00000114796 E016 26.4731258 0.0008359352 5.388452e-03 1.698348e-02 3 183650357 183650738 382 + 1.343 1.117 -0.800
ENSG00000114796 E017 28.3927247 0.0017864764 7.379305e-03 2.220367e-02 3 183650739 183651276 538 + 1.373 1.167 -0.725
ENSG00000114796 E018 16.9951861 0.0275487784 4.572058e-02 1.015205e-01 3 183663458 183663642 185 + 1.167 0.915 -0.923
ENSG00000114796 E019 0.0000000       3 183664101 183664133 33 +      
ENSG00000114796 E020 15.3108722 0.0012482714 1.794891e-01 3.004946e-01 3 183664921 183665039 119 + 1.108 0.994 -0.418
ENSG00000114796 E021 17.8002757 0.0010375163 2.719707e-01 4.107890e-01 3 183671034 183671222 189 + 1.163 1.089 -0.265
ENSG00000114796 E022 15.9262572 0.0012090485 2.283655e-01 3.604752e-01 3 183672296 183672484 189 + 1.122 1.028 -0.340
ENSG00000114796 E023 0.5922303 0.0180734457 6.059872e-01 7.262623e-01 3 183672485 183673008 524 + 0.144 0.256 1.028
ENSG00000114796 E024 164.3063970 0.0440510125 8.463172e-01 9.044727e-01 3 183679086 183684519 5434 + 2.078 2.145 0.222