ENSG00000114790

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000465093 ENSG00000114790 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF26 protein_coding protein_coding 7.343995 6.761589 7.711875 0.2260238 0.2617122 0.1894569 5.388302 2.869528 7.2333076 0.3271636 0.3802852 1.330816 0.7070625 0.4263333 0.93790000 0.5115667 0.0001744575 0.0001744575 FALSE TRUE
ENST00000483068 ENSG00000114790 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF26 protein_coding retained_intron 7.343995 6.761589 7.711875 0.2260238 0.2617122 0.1894569 1.705963 3.853796 0.2441648 0.4376585 0.2441648 -3.926183 0.2593875 0.5681000 0.03223333 -0.5358667 0.0061161605 0.0001744575 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114790 E001 0.0000000       3 154121003 154121235 233 +      
ENSG00000114790 E002 2.9776226 0.1497619017 4.637309e-01 6.035065e-01 3 154121390 154121415 26 + 0.647 0.532 -0.517
ENSG00000114790 E003 5.4144976 0.0740804676 2.584894e-01 3.957591e-01 3 154121416 154121439 24 + 0.866 0.703 -0.651
ENSG00000114790 E004 18.0087865 0.0776196643 3.507658e-02 8.179456e-02 3 154121440 154121519 80 + 1.386 1.087 -1.056
ENSG00000114790 E005 131.7959574 0.0007381190 6.437685e-18 3.229018e-16 3 154121942 154123075 1134 + 2.215 1.963 -0.844
ENSG00000114790 E006 31.8303827 0.0008853221 1.161371e-04 5.962071e-04 3 154124410 154124449 40 + 1.598 1.384 -0.735
ENSG00000114790 E007 48.9952499 0.0018263991 1.816631e-07 1.754999e-06 3 154129574 154129719 146 + 1.791 1.535 -0.872
ENSG00000114790 E008 0.0000000       3 154129720 154129723 4 +      
ENSG00000114790 E009 36.8463250 0.0019684933 2.710071e-03 9.403718e-03 3 154149389 154149445 57 + 1.634 1.481 -0.524
ENSG00000114790 E010 52.3701670 0.0004905104 1.683582e-03 6.230702e-03 3 154152772 154152932 161 + 1.772 1.650 -0.415
ENSG00000114790 E011 59.1289541 0.0003948238 4.130777e-02 9.344708e-02 3 154187685 154187837 153 + 1.804 1.744 -0.204
ENSG00000114790 E012 52.8663358 0.0004226763 1.397199e-01 2.476403e-01 3 154191289 154191418 130 + 1.746 1.708 -0.130
ENSG00000114790 E013 43.9862362 0.0043941550 1.691510e-01 2.870812e-01 3 154194644 154194718 75 + 1.670 1.618 -0.175
ENSG00000114790 E014 44.8854451 0.0083560205 3.969464e-01 5.407215e-01 3 154217869 154217958 90 + 1.668 1.643 -0.082
ENSG00000114790 E015 0.3289534 0.0287308739 8.049100e-01   3 154225785 154225855 71 + 0.102 0.146 0.598
ENSG00000114790 E016 63.1808592 0.0021214935 5.769601e-01 7.023148e-01 3 154225856 154226010 155 + 1.800 1.806 0.018
ENSG00000114790 E017 77.1014140 0.0003568887 2.803646e-01 4.202342e-01 3 154240370 154240579 210 + 1.895 1.885 -0.035
ENSG00000114790 E018 46.6920370 0.0011552983 1.579794e-02 4.228176e-02 3 154253116 154253183 68 + 1.714 1.618 -0.328
ENSG00000114790 E019 42.8063378 0.0005579346 4.088009e-01 5.524101e-01 3 154254720 154254784 65 + 1.642 1.630 -0.041
ENSG00000114790 E020 39.2533637 0.0005572399 4.738881e-01 6.127850e-01 3 154254785 154254824 40 + 1.604 1.596 -0.027
ENSG00000114790 E021 308.1645355 0.0085789327 1.550850e-02 4.164655e-02 3 154255331 154256876 1546 + 2.426 2.556 0.434
ENSG00000114790 E022 256.8499653 0.0013397953 3.348689e-34 7.755489e-32 3 154256877 154257827 951 + 2.229 2.566 1.123