ENSG00000114770

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334444 ENSG00000114770 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC5 protein_coding protein_coding 20.53625 15.03652 20.41977 0.216938 0.5602093 0.4412436 11.385723 8.123680 10.1876773 0.21996214 0.1612207 0.3262605 0.55506250 0.54010000 0.49996667 -0.04013333 5.703004e-01 1.199378e-07 FALSE  
ENST00000382494 ENSG00000114770 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC5 protein_coding protein_coding 20.53625 15.03652 20.41977 0.216938 0.5602093 0.4412436 2.203003 2.149854 1.8480750 0.20096638 0.2861935 -0.2171253 0.10935833 0.14266667 0.09040000 -0.05226667 1.401370e-01 1.199378e-07 FALSE  
ENST00000392579 ENSG00000114770 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC5 protein_coding protein_coding 20.53625 15.03652 20.41977 0.216938 0.5602093 0.4412436 1.349802 1.302945 1.8401843 0.09694626 0.3346069 0.4948628 0.06797500 0.08673333 0.09073333 0.00400000 9.948540e-01 1.199378e-07 FALSE  
ENST00000427120 ENSG00000114770 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC5 protein_coding protein_coding 20.53625 15.03652 20.41977 0.216938 0.5602093 0.4412436 2.768586 1.049820 3.1422967 0.02233531 0.1663356 1.5725843 0.12639167 0.06980000 0.15366667 0.08386667 1.973728e-06 1.199378e-07 FALSE  
ENST00000446941 ENSG00000114770 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCC5 protein_coding protein_coding 20.53625 15.03652 20.41977 0.216938 0.5602093 0.4412436 1.121958 1.420835 0.7995425 0.26563399 0.1067348 -0.8216788 0.06052917 0.09436667 0.03943333 -0.05493333 3.461492e-02 1.199378e-07    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114770 E001 0.5932745 0.0327489103 8.051498e-01 8.760386e-01 3 183919934 183919937 4 - 0.191 0.246 0.465
ENSG00000114770 E002 0.5932745 0.0327489103 8.051498e-01 8.760386e-01 3 183919938 183919938 1 - 0.191 0.246 0.465
ENSG00000114770 E003 482.7134532 0.0049161348 4.399576e-19 2.529549e-17 3 183919939 183921401 1463 - 2.495 2.831 1.119
ENSG00000114770 E004 96.4147053 0.0003199978 8.346965e-03 2.465861e-02 3 183925555 183925659 105 - 1.924 2.047 0.413
ENSG00000114770 E005 83.9417546 0.0003199619 3.528062e-03 1.180698e-02 3 183925660 183925719 60 - 1.856 1.996 0.471
ENSG00000114770 E006 104.6827550 0.0002744242 4.355353e-02 9.756516e-02 3 183927330 183927443 114 - 1.973 2.070 0.327
ENSG00000114770 E007 96.4879124 0.0003429503 1.669752e-01 2.842661e-01 3 183928747 183928825 79 - 1.946 2.024 0.261
ENSG00000114770 E008 117.5963521 0.0005235300 2.632950e-01 4.011747e-01 3 183937901 183938060 160 - 2.038 2.103 0.219
ENSG00000114770 E009 1.2617653 0.0729239384 3.307262e-01 4.743191e-01 3 183942433 183942515 83 - 0.425 0.247 -1.113
ENSG00000114770 E010 110.6575404 0.0017293889 4.761285e-01 6.148117e-01 3 183942727 183942916 190 - 2.046 2.047 0.002
ENSG00000114770 E011 74.4531779 0.0003655248 8.890146e-01 9.330192e-01 3 183945850 183945939 90 - 1.861 1.894 0.112
ENSG00000114770 E012 84.9782227 0.0003265364 3.155435e-01 4.583066e-01 3 183947324 183947510 187 - 1.900 1.967 0.222
ENSG00000114770 E013 68.3185840 0.0003825024 2.149737e-01 3.444011e-01 3 183949753 183949881 129 - 1.799 1.879 0.271
ENSG00000114770 E014 74.8543772 0.0003208135 7.571207e-01 8.420556e-01 3 183949972 183950125 154 - 1.871 1.886 0.051
ENSG00000114770 E015 69.5524500 0.0003504819 7.413876e-01 8.305829e-01 3 183951441 183951570 130 - 1.841 1.854 0.046
ENSG00000114770 E016 79.7756926 0.0003285435 8.855187e-01 9.307733e-01 3 183951857 183952003 147 - 1.890 1.923 0.112
ENSG00000114770 E017 99.0941574 0.0006325459 1.799729e-01 3.011475e-01 3 183953086 183953270 185 - 1.960 2.036 0.258
ENSG00000114770 E018 80.5656690 0.0003316459 4.342502e-02 9.734059e-02 3 183959733 183959835 103 - 1.856 1.963 0.360
ENSG00000114770 E019 93.8527594 0.0002993924 5.636900e-01 6.911397e-01 3 183961511 183961654 144 - 1.974 1.981 0.023
ENSG00000114770 E020 93.9878417 0.0027529261 9.252965e-01 9.569650e-01 3 183963385 183963588 204 - 1.962 1.986 0.079
ENSG00000114770 E021 46.2020491 0.0099378761 1.425146e-01 2.514549e-01 3 183965185 183965257 73 - 1.701 1.624 -0.260
ENSG00000114770 E022 60.4855160 0.0006824957 2.185978e-01 3.487326e-01 3 183965377 183965501 125 - 1.797 1.767 -0.100
ENSG00000114770 E023 0.0000000       3 183967304 183967694 391 -      
ENSG00000114770 E024 43.9334325 0.0185624257 1.473842e-01 2.581379e-01 3 183967695 183967766 72 - 1.689 1.597 -0.312
ENSG00000114770 E025 114.7338410 0.0003940253 2.673174e-04 1.246523e-03 3 183971563 183971919 357 - 2.106 2.011 -0.319
ENSG00000114770 E026 1.1748942 0.1098091128 4.862707e-01 6.240561e-01 3 183971920 183972034 115 - 0.262 0.405 0.892
ENSG00000114770 E027 29.7162355 0.0088494473 2.753405e-03 9.531737e-03 3 183977517 183977517 1 - 1.570 1.360 -0.724
ENSG00000114770 E028 61.3846564 0.0059157787 3.805356e-03 1.259567e-02 3 183977518 183977624 107 - 1.854 1.713 -0.476
ENSG00000114770 E029 65.2067483 0.0003913699 2.345239e-04 1.110691e-03 3 183978503 183978651 149 - 1.879 1.744 -0.456
ENSG00000114770 E030 51.6187962 0.0004702751 1.309410e-02 3.612572e-02 3 183981727 183981874 148 - 1.763 1.668 -0.321
ENSG00000114770 E031 47.4452417 0.0004943599 1.116712e-01 2.080132e-01 3 183982451 183982624 174 - 1.708 1.654 -0.183
ENSG00000114770 E032 71.5554753 0.0068941080 2.768839e-05 1.660197e-04 3 183982774 183983007 234 - 1.946 1.727 -0.738
ENSG00000114770 E033 5.3551388 0.0074431631 6.940693e-03 2.106897e-02 3 183983435 183983576 142 - 0.928 0.567 -1.474
ENSG00000114770 E034 162.9591518 0.0010425717 1.710763e-05 1.077492e-04 3 183983753 183984663 911 - 2.132 2.294 0.539
ENSG00000114770 E035 65.0128846 0.0003687893 8.714393e-01 9.213007e-01 3 183984664 183984894 231 - 1.801 1.835 0.117
ENSG00000114770 E036 24.9528703 0.0008405377 2.648266e-02 6.491635e-02 3 183984895 183985043 149 - 1.465 1.336 -0.446
ENSG00000114770 E037 23.6618450 0.0015196252 6.974782e-01 7.975929e-01 3 183985044 183985303 260 - 1.394 1.393 -0.002
ENSG00000114770 E038 26.3895710 0.0100778619 4.587728e-01 5.990624e-01 3 183985304 183985378 75 - 1.453 1.419 -0.118
ENSG00000114770 E039 12.1750375 0.0244075357 3.995795e-01 5.433160e-01 3 183985379 183985455 77 - 1.155 1.081 -0.266
ENSG00000114770 E040 123.5110234 0.0009089909 1.702430e-23 1.595056e-21 3 183985456 183987769 2314 - 2.220 1.888 -1.113
ENSG00000114770 E041 40.9241858 0.0112811696 7.236765e-02 1.472861e-01 3 183987770 183987770 1 - 1.671 1.559 -0.383
ENSG00000114770 E042 112.2117251 0.0005434049 1.283620e-04 6.517243e-04 3 183987771 183987917 147 - 2.098 1.993 -0.354
ENSG00000114770 E043 56.4587734 0.0005305158 3.946112e-02 9.003261e-02 3 183988572 183988572 1 - 1.789 1.719 -0.237
ENSG00000114770 E044 143.1342201 0.0002488582 7.755831e-07 6.598343e-06 3 183988573 183988727 155 - 2.210 2.089 -0.403
ENSG00000114770 E045 122.7786190 0.0002337520 1.211737e-08 1.471632e-07 3 183989226 183989383 158 - 2.158 2.001 -0.526
ENSG00000114770 E046 20.0433223 0.0231566918 1.511002e-05 9.638206e-05 3 184000663 184001251 589 - 1.028 1.528 1.759
ENSG00000114770 E047 1.3244325 0.0933406339 1.715574e-01 2.902344e-01 3 184009889 184009977 89 - 0.191 0.470 1.822
ENSG00000114770 E048 122.5518766 0.0002646528 8.586862e-05 4.556737e-04 3 184014264 184014447 184 - 2.135 2.036 -0.331
ENSG00000114770 E049 0.1451727 0.0436061962 6.197689e-01   3 184017351 184017444 94 - 0.106 0.001 -7.694
ENSG00000114770 E050 48.0291480 0.0005895648 3.545077e-02 8.251983e-02 3 184017830 184017939 110 - 1.726 1.646 -0.271