ENSG00000114745

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000695414 ENSG00000114745 HEK293_OSMI2_2hA HEK293_TMG_2hB GORASP1 protein_coding protein_coding 36.33535 49.71861 24.38932 1.616588 0.5093685 -1.027235 1.355363 1.099477 2.729316 1.0994771 0.2408337 1.303936 0.03901667 0.02156667 0.11193333 0.09036667 8.733874e-02 9.501763e-05 FALSE TRUE
ENST00000695430 ENSG00000114745 HEK293_OSMI2_2hA HEK293_TMG_2hB GORASP1 protein_coding protein_coding 36.33535 49.71861 24.38932 1.616588 0.5093685 -1.027235 3.498559 6.825368 2.416358 0.9719417 0.1566499 -1.494227 0.09408333 0.13643333 0.09936667 -0.03706667 3.091107e-01 9.501763e-05 FALSE TRUE
ENST00000695592 ENSG00000114745 HEK293_OSMI2_2hA HEK293_TMG_2hB GORASP1 protein_coding processed_transcript 36.33535 49.71861 24.38932 1.616588 0.5093685 -1.027235 20.296168 32.099780 11.175154 0.2505540 0.8412037 -1.521428 0.54628333 0.64670000 0.45730000 -0.18940000 9.501763e-05 9.501763e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114745 E001 15.135246 0.0176047935 3.004727e-04 1.381441e-03 3 39095222 39096598 1377 - 1.395 1.031 -1.291
ENSG00000114745 E002 1.947797 0.0075252937 4.104135e-01 5.540034e-01 3 39096599 39096613 15 - 0.536 0.402 -0.676
ENSG00000114745 E003 2.024069 0.0072022719 8.224309e-01 8.880375e-01 3 39096614 39096614 1 - 0.469 0.438 -0.161
ENSG00000114745 E004 2.024069 0.0072022719 8.224309e-01 8.880375e-01 3 39096615 39096621 7 - 0.469 0.438 -0.161
ENSG00000114745 E005 1.876820 0.0075869005 8.277486e-01 8.917261e-01 3 39096622 39096623 2 - 0.391 0.438 0.254
ENSG00000114745 E006 2.462708 0.0061986296 4.310718e-01 5.736611e-01 3 39096624 39096633 10 - 0.593 0.471 -0.577
ENSG00000114745 E007 2.281003 0.0064516380 3.274633e-01 4.709293e-01 3 39096634 39096636 3 - 0.593 0.438 -0.747
ENSG00000114745 E008 3.896737 0.0040188464 9.886851e-01 9.969716e-01 3 39096637 39096641 5 - 0.644 0.651 0.032
ENSG00000114745 E009 3.863326 0.0040505313 9.879079e-01 9.964975e-01 3 39096642 39096643 2 - 0.644 0.651 0.031
ENSG00000114745 E010 13.234650 0.0013114252 6.292618e-02 1.315905e-01 3 39096644 39096658 15 - 0.944 1.155 0.769
ENSG00000114745 E011 14.667533 0.0012035886 1.740723e-02 4.583938e-02 3 39096659 39096664 6 - 0.944 1.205 0.947
ENSG00000114745 E012 15.920788 0.0011606348 5.073166e-03 1.613065e-02 3 39096665 39096673 9 - 0.944 1.244 1.087
ENSG00000114745 E013 18.828284 0.0009889945 1.777161e-04 8.684204e-04 3 39096674 39096679 6 - 0.944 1.327 1.378
ENSG00000114745 E014 19.305531 0.0009986239 2.472780e-04 1.163993e-03 3 39096680 39096681 2 - 0.967 1.336 1.321
ENSG00000114745 E015 22.680837 0.0050696812 8.306474e-05 4.425175e-04 3 39096682 39096683 2 - 1.011 1.407 1.408
ENSG00000114745 E016 26.811501 0.0043418352 1.289970e-05 8.351763e-05 3 39096684 39096691 8 - 1.068 1.478 1.442
ENSG00000114745 E017 51.293804 0.0005568096 7.418119e-08 7.725470e-07 3 39096692 39096715 24 - 1.395 1.740 1.178
ENSG00000114745 E018 54.497031 0.0004588484 2.794442e-08 3.165313e-07 3 39096716 39096722 7 - 1.420 1.765 1.177
ENSG00000114745 E019 53.720904 0.0004590362 2.113230e-10 3.523855e-09 3 39096723 39096730 8 - 1.360 1.767 1.391
ENSG00000114745 E020 48.753678 0.0006278377 8.880566e-09 1.105168e-07 3 39096731 39096732 2 - 1.341 1.724 1.313
ENSG00000114745 E021 421.247013 0.0046053035 7.618241e-06 5.199353e-05 3 39096733 39096967 235 - 2.432 2.617 0.616
ENSG00000114745 E022 360.654280 0.0059977814 2.211600e-03 7.878990e-03 3 39096968 39097034 67 - 2.396 2.542 0.486
ENSG00000114745 E023 806.347852 0.0018928619 1.303678e-06 1.056231e-05 3 39097035 39097451 417 - 2.758 2.886 0.428
ENSG00000114745 E024 1413.835217 0.0003502976 1.091775e-01 2.043284e-01 3 39097452 39098489 1038 - 3.074 3.107 0.108
ENSG00000114745 E025 7.854373 0.0026836969 3.653883e-03 1.216636e-02 3 39098490 39098740 251 - 1.103 0.779 -1.221
ENSG00000114745 E026 254.460868 0.0001778155 1.727358e-02 4.555224e-02 3 39098741 39098815 75 - 2.385 2.340 -0.152
ENSG00000114745 E027 196.261785 0.0021520394 5.563992e-02 1.190784e-01 3 39098816 39098853 38 - 2.278 2.225 -0.179
ENSG00000114745 E028 189.725412 0.0020337633 2.040694e-01 3.312684e-01 3 39098854 39098893 40 - 2.247 2.216 -0.104
ENSG00000114745 E029 16.131056 0.0011255961 1.015958e-07 1.030078e-06 3 39098894 39099167 274 - 1.451 1.015 -1.542
ENSG00000114745 E030 14.611122 0.0012054488 8.692336e-05 4.606515e-04 3 39099168 39099352 185 - 1.360 1.024 -1.193
ENSG00000114745 E031 307.083205 0.0015964233 1.453581e-01 2.553447e-01 3 39099353 39099503 151 - 2.454 2.426 -0.094
ENSG00000114745 E032 255.920787 0.0031693944 7.766038e-02 1.557046e-01 3 39100305 39100434 130 - 2.392 2.343 -0.163
ENSG00000114745 E033 118.003210 0.0058136627 3.234801e-01 4.668134e-01 3 39100435 39100453 19 - 2.051 2.014 -0.122
ENSG00000114745 E034 93.132515 0.0038056676 5.817151e-01 7.062152e-01 3 39100454 39100454 1 - 1.933 1.919 -0.047
ENSG00000114745 E035 75.827292 0.0037121482 9.716550e-01 9.862801e-01 3 39100455 39100456 2 - 1.824 1.839 0.049
ENSG00000114745 E036 120.318064 0.0030809933 5.368430e-01 6.685370e-01 3 39100457 39100503 47 - 2.043 2.030 -0.045
ENSG00000114745 E037 17.542417 0.0019241654 1.317917e-10 2.281182e-09 3 39100504 39100746 243 - 1.526 1.015 -1.802
ENSG00000114745 E038 121.382174 0.0002922837 6.255177e-01 7.416184e-01 3 39100747 39100787 41 - 2.040 2.035 -0.016
ENSG00000114745 E039 142.645083 0.0002243601 3.148363e-04 1.440174e-03 3 39100788 39100850 63 - 2.176 2.074 -0.341
ENSG00000114745 E040 93.881980 0.0002968078 1.940120e-04 9.382498e-04 3 39100851 39100877 27 - 2.016 1.884 -0.443
ENSG00000114745 E041 16.105444 0.0106444470 1.509513e-05 9.630658e-05 3 39100878 39101015 138 - 1.436 1.033 -1.422
ENSG00000114745 E042 150.958210 0.0002660494 2.524197e-02 6.236979e-02 3 39101016 39101102 87 - 2.169 2.111 -0.194
ENSG00000114745 E043 8.884853 0.0618531099 3.167741e-03 1.076041e-02 3 39101103 39101182 80 - 1.230 0.765 -1.729
ENSG00000114745 E044 13.147722 0.0075997033 1.069418e-07 1.080696e-06 3 39101183 39101509 327 - 1.403 0.890 -1.846
ENSG00000114745 E045 6.073924 0.0141767823 1.331449e-02 3.665198e-02 3 39101510 39101570 61 - 1.011 0.692 -1.240
ENSG00000114745 E046 34.980195 0.0103083865 1.543620e-10 2.638345e-09 3 39101571 39102677 1107 - 1.788 1.316 -1.615
ENSG00000114745 E047 84.471040 0.0043895016 2.694327e-01 4.079460e-01 3 39102678 39102692 15 - 1.908 1.863 -0.150
ENSG00000114745 E048 210.880675 0.0036704555 2.761473e-02 6.724501e-02 3 39102693 39102839 147 - 2.322 2.251 -0.236
ENSG00000114745 E049 128.893403 0.0021365583 4.417463e-03 1.431216e-02 3 39102840 39102875 36 - 2.130 2.031 -0.332
ENSG00000114745 E050 97.101282 0.0004048452 3.263329e-02 7.706367e-02 3 39102876 39102881 6 - 1.988 1.917 -0.239
ENSG00000114745 E051 5.232788 0.0042171453 1.563310e-02 4.191817e-02 3 39102882 39102926 45 - 0.944 0.630 -1.252
ENSG00000114745 E052 5.507709 0.0224770854 6.382221e-05 3.501673e-04 3 39102927 39102951 25 - 1.086 0.532 -2.219
ENSG00000114745 E053 5.658076 0.0416255653 1.178380e-02 3.301593e-02 3 39102952 39102999 48 - 1.011 0.633 -1.491
ENSG00000114745 E054 7.420001 0.0112897630 1.157232e-02 3.251911e-02 3 39103000 39103107 108 - 1.069 0.764 -1.156
ENSG00000114745 E055 9.027293 0.0057752755 6.779865e-04 2.818452e-03 3 39103108 39103472 365 - 1.179 0.810 -1.371
ENSG00000114745 E056 159.536526 0.0029291495 1.982021e-02 5.110348e-02 3 39103473 39103547 75 - 2.207 2.129 -0.260
ENSG00000114745 E057 80.947869 0.0067644067 3.979671e-02 9.064790e-02 3 39103548 39103553 6 - 1.933 1.830 -0.346
ENSG00000114745 E058 2.849487 0.0124228094 1.607034e-01 2.760379e-01 3 39103554 39103725 172 - 0.690 0.471 -0.990
ENSG00000114745 E059 2.434595 0.0062040954 1.895650e-01 3.132136e-01 3 39106386 39106567 182 - 0.644 0.438 -0.969
ENSG00000114745 E060 1.437139 0.0090263257 3.767550e-01 5.210813e-01 3 39106568 39106634 67 - 0.469 0.320 -0.840
ENSG00000114745 E061 1.038343 0.0264048074 7.439572e-02 1.505712e-01 3 39106969 39106987 19 - 0.469 0.157 -2.156
ENSG00000114745 E062 0.891094 0.2143999092 2.418435e-01 3.763589e-01 3 39106988 39106992 5 - 0.391 0.161 -1.703
ENSG00000114745 E063 2.654178 0.2796970106 4.140372e-01 5.574531e-01 3 39106993 39107182 190 - 0.645 0.453 -0.893
ENSG00000114745 E064 2.399335 0.3741582310 3.922515e-01 5.361883e-01 3 39107183 39107478 296 - 0.646 0.413 -1.111
ENSG00000114745 E065 136.625780 0.0106995586 2.903687e-02 7.007844e-02 3 39107479 39108063 585 - 2.163 2.053 -0.369
ENSG00000114745 E066 0.000000       3 39108215 39108369 155 -