ENSG00000114735

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000424388 ENSG00000114735 HEK293_OSMI2_2hA HEK293_TMG_2hB HEMK1 protein_coding nonsense_mediated_decay 11.4423 18.60711 7.384218 0.9070585 0.2352462 -1.33216 1.4507230 2.0305668 1.3707400 0.2723769 0.34278302 -0.5635282 0.1363667 0.10830000 0.18316667 0.07486667 0.334395566 0.007970379 TRUE  
ENST00000434410 ENSG00000114735 HEK293_OSMI2_2hA HEK293_TMG_2hB HEMK1 protein_coding protein_coding 11.4423 18.60711 7.384218 0.9070585 0.2352462 -1.33216 0.6691261 0.7920487 0.6975368 0.1348306 0.03568092 -0.1808848 0.0659750 0.04223333 0.09483333 0.05260000 0.007970379 0.007970379 FALSE  
ENST00000455834 ENSG00000114735 HEK293_OSMI2_2hA HEK293_TMG_2hB HEMK1 protein_coding protein_coding 11.4423 18.60711 7.384218 0.9070585 0.2352462 -1.33216 5.5894464 10.5846096 2.9091597 0.2970902 0.35289092 -1.8597054 0.4624583 0.57240000 0.39510000 -0.17730000 0.101936758 0.007970379 FALSE  
MSTRG.23005.2 ENSG00000114735 HEK293_OSMI2_2hA HEK293_TMG_2hB HEMK1 protein_coding   11.4423 18.60711 7.384218 0.9070585 0.2352462 -1.33216 1.6484982 2.5751832 0.9933734 0.2888567 0.03993778 -1.3654080 0.1425708 0.13803333 0.13513333 -0.00290000 0.986441276 0.007970379 FALSE  
MSTRG.23005.4 ENSG00000114735 HEK293_OSMI2_2hA HEK293_TMG_2hB HEMK1 protein_coding   11.4423 18.60711 7.384218 0.9070585 0.2352462 -1.33216 1.3226508 2.0572517 1.0520125 0.5044081 0.17825199 -0.9609134 0.1203417 0.10850000 0.14296667 0.03446667 0.664273126 0.007970379 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114735 E001 9.039681 0.0023057076 8.116071e-01 8.804339e-01 3 50569152 50569273 122 + 0.969 0.918 -0.191
ENSG00000114735 E002 3.948091 0.0100568021 9.664732e-01 9.829678e-01 3 50569431 50569477 47 + 0.636 0.610 -0.113
ENSG00000114735 E003 4.538245 0.0039920776 3.907683e-01 5.347165e-01 3 50569478 50569490 13 + 0.777 0.629 -0.613
ENSG00000114735 E004 4.828591 0.0040292643 1.598108e-01 2.748636e-01 3 50569491 50569492 2 + 0.850 0.629 -0.902
ENSG00000114735 E005 13.080659 0.0013856887 6.858837e-01 7.884960e-01 3 50569493 50569521 29 + 1.120 1.055 -0.236
ENSG00000114735 E006 24.439949 0.0008273605 9.830342e-01 9.934638e-01 3 50569522 50569545 24 + 1.343 1.320 -0.079
ENSG00000114735 E007 31.520126 0.0018134237 6.069946e-01 7.270510e-01 3 50569546 50569566 21 + 1.413 1.427 0.046
ENSG00000114735 E008 31.655746 0.0054540192 4.192501e-01 5.624929e-01 3 50569567 50569569 3 + 1.394 1.435 0.140
ENSG00000114735 E009 30.698961 0.0064658886 2.347982e-01 3.681295e-01 3 50569570 50569574 5 + 1.354 1.429 0.261
ENSG00000114735 E010 11.868653 0.0017826048 6.985478e-01 7.984849e-01 3 50569575 50569811 237 + 1.082 1.016 -0.238
ENSG00000114735 E011 6.074382 0.0027856938 5.919523e-01 7.145908e-01 3 50569812 50570505 694 + 0.735 0.790 0.223
ENSG00000114735 E012 1.682457 0.2824888259 7.066364e-01 8.047645e-01 3 50570506 50570801 296 + 0.425 0.369 -0.309
ENSG00000114735 E013 1.323287 0.0119305420 4.283669e-01 5.711511e-01 3 50570802 50570930 129 + 0.191 0.333 1.056
ENSG00000114735 E014 272.287775 0.0003191912 5.890777e-01 7.121780e-01 3 50570931 50571294 364 + 2.363 2.351 -0.041
ENSG00000114735 E015 118.508130 0.0060329934 6.654770e-01 7.731529e-01 3 50571295 50571332 38 + 2.000 1.998 -0.006
ENSG00000114735 E016 2.687363 0.0106941652 1.614321e-02 4.304792e-02 3 50571333 50571709 377 + 0.777 0.370 -1.891
ENSG00000114735 E017 174.853152 0.0019476450 9.744751e-01 9.880667e-01 3 50571710 50571801 92 + 2.184 2.159 -0.081
ENSG00000114735 E018 145.386903 0.0016181188 1.589085e-01 2.736827e-01 3 50572115 50572208 94 + 2.063 2.091 0.096
ENSG00000114735 E019 114.839101 0.0031971302 3.356665e-01 4.794618e-01 3 50577052 50577123 72 + 1.970 1.991 0.069
ENSG00000114735 E020 118.630263 0.0002536118 5.306985e-01 6.632445e-01 3 50577124 50577186 63 + 1.998 1.996 -0.007
ENSG00000114735 E021 153.042934 0.0002796290 1.569364e-01 2.710172e-01 3 50577509 50577573 65 + 2.087 2.108 0.072
ENSG00000114735 E022 111.110816 0.0010726259 4.419528e-06 3.184249e-05 3 50577826 50577875 50 + 1.829 2.004 0.591
ENSG00000114735 E023 147.884648 0.0002677497 3.478313e-07 3.175997e-06 3 50578821 50578926 106 + 1.963 2.120 0.527
ENSG00000114735 E024 161.308103 0.0002705432 3.647273e-05 2.122519e-04 3 50579844 50579939 96 + 2.035 2.149 0.381
ENSG00000114735 E025 6.923561 0.0023771525 1.790037e-01 2.998888e-01 3 50579940 50580115 176 + 0.969 0.776 -0.738
ENSG00000114735 E026 152.013527 0.0002738945 3.754563e-05 2.178933e-04 3 50580116 50580229 114 + 2.005 2.123 0.396
ENSG00000114735 E027 22.551178 0.0024866205 2.612241e-01 3.988694e-01 3 50580230 50580380 151 + 1.385 1.269 -0.402
ENSG00000114735 E028 148.234754 0.0004033081 4.696607e-05 2.664207e-04 3 50580381 50580495 115 + 1.998 2.117 0.400
ENSG00000114735 E029 131.331455 0.0002707119 3.946812e-01 5.385148e-01 3 50580496 50581611 1116 + 2.037 2.042 0.016
ENSG00000114735 E030 8.532121 0.1484492878 1.032786e-01 1.954647e-01 3 50581612 50581674 63 + 1.136 0.798 -1.264
ENSG00000114735 E031 94.201999 0.0110015335 3.666322e-11 6.953385e-10 3 50581675 50584034 2360 + 2.187 1.757 -1.443
ENSG00000114735 E032 31.921946 0.0443700411 3.549024e-02 8.259751e-02 3 50584035 50584335 301 + 1.644 1.353 -1.002
ENSG00000114735 E033 25.120938 0.0008020527 1.119313e-01 2.083972e-01 3 50584336 50584480 145 + 1.440 1.296 -0.501
ENSG00000114735 E034 213.682598 0.0034454197 1.013989e-15 3.822829e-14 3 50584481 50596168 11688 + 2.466 2.159 -1.023