ENSG00000114698

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354952 ENSG00000114698 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR4 protein_coding protein_coding 0.5916757 0.4510626 0.8076745 0.03530814 0.07070707 0.8265639 0.13307459 0.10955706 0.11635607 0.09505080 0.11635607 0.07979564 0.26980833 0.21463333 0.14920000 -0.06543333 0.7715665188 0.0001173723 FALSE TRUE
ENST00000383083 ENSG00000114698 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR4 protein_coding protein_coding 0.5916757 0.4510626 0.8076745 0.03530814 0.07070707 0.8265639 0.10620163 0.06741482 0.21967131 0.06741482 0.10702545 1.56888897 0.16117917 0.16646667 0.28710000 0.12063333 0.6607170805 0.0001173723 FALSE TRUE
ENST00000433593 ENSG00000114698 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR4 protein_coding protein_coding 0.5916757 0.4510626 0.8076745 0.03530814 0.07070707 0.8265639 0.03530723 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.06548750 0.00000000 0.00000000 0.00000000   0.0001173723 FALSE TRUE
ENST00000446574 ENSG00000114698 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR4 protein_coding protein_coding 0.5916757 0.4510626 0.8076745 0.03530814 0.07070707 0.8265639 0.02404744 0.00000000 0.09231965 0.00000000 0.09231965 3.35501134 0.02744167 0.00000000 0.09803333 0.09803333 0.8858710890 0.0001173723 FALSE TRUE
ENST00000460350 ENSG00000114698 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR4 protein_coding protein_coding 0.5916757 0.4510626 0.8076745 0.03530814 0.07070707 0.8265639 0.09577968 0.10969864 0.09120927 0.06828140 0.09120927 -0.24206534 0.17795833 0.26056667 0.11693333 -0.14363333 0.6537997657 0.0001173723 FALSE TRUE
ENST00000475019 ENSG00000114698 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR4 protein_coding retained_intron 0.5916757 0.4510626 0.8076745 0.03530814 0.07070707 0.8265639 0.04646698 0.12943334 0.00000000 0.01694159 0.00000000 -3.80150367 0.07487917 0.29113333 0.00000000 -0.29113333 0.0001173723 0.0001173723 FALSE TRUE
ENST00000476202 ENSG00000114698 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR4 protein_coding protein_coding 0.5916757 0.4510626 0.8076745 0.03530814 0.07070707 0.8265639 0.04592360 0.00000000 0.03922912 0.00000000 0.03922912 2.29951182 0.06862917 0.00000000 0.04166667 0.04166667 0.9036727786 0.0001173723 FALSE FALSE
ENST00000493382 ENSG00000114698 HEK293_OSMI2_2hA HEK293_TMG_2hB PLSCR4 protein_coding protein_coding 0.5916757 0.4510626 0.8076745 0.03530814 0.07070707 0.8265639 0.05678126 0.03495874 0.21210261 0.03495874 0.10766156 2.30455300 0.07344583 0.06716667 0.25990000 0.19273333 0.6414832824 0.0001173723 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114698 E001 0.0000000       3 146192335 146192338 4 -      
ENSG00000114698 E002 0.0000000       3 146192339 146192404 66 -      
ENSG00000114698 E003 11.9178605 0.002383047 0.15424385 0.26744494 3 146192405 146194290 1886 - 1.055 1.181 0.455
ENSG00000114698 E004 2.2958685 0.007254766 0.78781444 0.86408500 3 146194291 146194356 66 - 0.539 0.498 -0.198
ENSG00000114698 E005 3.2039168 0.010659423 0.08140409 0.16175710 3 146194357 146194455 99 - 0.715 0.434 -1.286
ENSG00000114698 E006 4.0207009 0.041702916 0.08369876 0.16533872 3 146195124 146195282 159 - 0.791 0.498 -1.271
ENSG00000114698 E007 0.6599951 0.075594431 0.01089946 0.03092139 3 146196405 146196631 227 - 0.000 0.433 13.804
ENSG00000114698 E008 3.2139171 0.005250014 0.88938580 0.93329729 3 146196632 146196705 74 - 0.623 0.603 -0.088
ENSG00000114698 E009 3.6827341 0.010212453 0.22551277 0.35701788 3 146196706 146196793 88 - 0.735 0.554 -0.782
ENSG00000114698 E010 3.6001320 0.038769807 0.13194517 0.23682700 3 146199813 146200008 196 - 0.754 0.497 -1.128
ENSG00000114698 E011 1.0674006 0.012669035 0.73322331 0.82447395 3 146200009 146200039 31 - 0.298 0.360 0.387
ENSG00000114698 E012 2.1014772 0.007431150 0.88092832 0.92766316 3 146201035 146201077 43 - 0.473 0.498 0.127
ENSG00000114698 E013 2.9787528 0.012909965 0.47337097 0.61230019 3 146206526 146206586 61 - 0.539 0.648 0.485
ENSG00000114698 E014 3.9269033 0.116583088 0.22100543 0.35162885 3 146206587 146206761 175 - 0.596 0.791 0.813
ENSG00000114698 E015 5.7486587 0.003846527 0.30871534 0.45098930 3 146220815 146220925 111 - 0.773 0.896 0.482
ENSG00000114698 E016 2.4536249 0.008775935 0.56853876 0.69519181 3 146222065 146222092 28 - 0.507 0.602 0.438
ENSG00000114698 E017 0.0000000       3 146222093 146222199 107 -      
ENSG00000114698 E018 0.1451727 0.046785426 0.95623486   3 146222200 146222371 172 - 0.096 0.000 -10.715
ENSG00000114698 E019 0.1451727 0.046785426 0.95623486   3 146222372 146222433 62 - 0.096 0.000 -10.715
ENSG00000114698 E020 0.5953508 0.019079959 0.59150143 0.71427406 3 146223733 146223777 45 - 0.174 0.269 0.801
ENSG00000114698 E021 1.1426289 0.012119385 0.72708729 0.81992729 3 146250557 146250637 81 - 0.298 0.360 0.390
ENSG00000114698 E022 0.2987644 0.028173927 0.42743526   3 146250638 146250867 230 - 0.174 0.000 -11.686
ENSG00000114698 E023 4.1081461 0.004225337 0.83609402 0.89750988 3 146250960 146251079 120 - 0.715 0.687 -0.114
ENSG00000114698 E024 1.6294274 0.009190022 0.82150003 0.88744208 3 146251080 146251083 4 - 0.394 0.435 0.220
ENSG00000114698 E025 1.6294274 0.009190022 0.82150003 0.88744208 3 146251084 146251105 22 - 0.394 0.435 0.220
ENSG00000114698 E026 1.1124400 0.011904917 0.65801748 0.76724359 3 146251106 146251125 20 - 0.349 0.270 -0.518
ENSG00000114698 E027 0.5922303 0.018104494 0.64411749 0.75648522 3 146251126 146251143 18 - 0.240 0.155 -0.782
ENSG00000114698 E028 0.2966881 0.028018896 0.42763555   3 146251144 146251179 36 - 0.174 0.000 -11.686