ENSG00000114650

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000441517 ENSG00000114650 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAP protein_coding nonsense_mediated_decay 86.03606 105.1742 62.4474 7.139514 1.331638 -0.751974 6.532699 10.85026 2.887571 0.5771389 0.2402423 -1.906143 0.07160833 0.1036333 0.04613333 -0.05750000 2.338786e-08 2.338786e-08 FALSE TRUE
ENST00000648151 ENSG00000114650 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAP protein_coding protein_coding 86.03606 105.1742 62.4474 7.139514 1.331638 -0.751974 7.668856 13.96774 5.164350 2.3240404 1.2432626 -1.433682 0.08765417 0.1310667 0.08193333 -0.04913333 3.310604e-01 2.338786e-08 FALSE TRUE
MSTRG.22880.2 ENSG00000114650 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAP protein_coding   86.03606 105.1742 62.4474 7.139514 1.331638 -0.751974 51.968163 54.18161 40.383009 5.3688415 0.4528603 -0.423964 0.60880000 0.5146667 0.64716667 0.13250000 4.212449e-02 2.338786e-08 FALSE TRUE
MSTRG.22880.3 ENSG00000114650 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAP protein_coding   86.03606 105.1742 62.4474 7.139514 1.331638 -0.751974 6.375201 12.52548 2.483867 1.1118869 1.2479213 -2.329561 0.06820833 0.1199667 0.04016667 -0.07980000 5.338334e-01 2.338786e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114650 E001 5.465378 0.1725406315 2.020486e-01 3.287598e-01 3 47413681 47413712 32 - 0.510 0.869 1.516
ENSG00000114650 E002 20.778290 0.0180198049 3.609903e-07 3.284910e-06 3 47413713 47413735 23 - 0.772 1.425 2.379
ENSG00000114650 E003 1527.731580 0.0023727082 3.022445e-11 5.817854e-10 3 47413736 47414099 364 - 3.007 3.197 0.631
ENSG00000114650 E004 1399.107016 0.0021981103 1.263367e-07 1.258630e-06 3 47414180 47414386 207 - 2.998 3.151 0.509
ENSG00000114650 E005 850.986184 0.0027270360 6.809468e-05 3.709551e-04 3 47414572 47414652 81 - 2.793 2.931 0.461
ENSG00000114650 E006 1096.450269 0.0046177519 1.018533e-03 4.022657e-03 3 47414827 47414993 167 - 2.903 3.042 0.463
ENSG00000114650 E007 698.386305 0.0044883899 5.452446e-05 3.043547e-04 3 47415098 47415180 83 - 2.682 2.853 0.571
ENSG00000114650 E008 583.547066 0.0019977196 1.757553e-10 2.973682e-09 3 47417122 47417207 86 - 2.581 2.781 0.665
ENSG00000114650 E009 1264.112321 0.0001938714 4.452691e-30 7.558682e-28 3 47417304 47417823 520 - 2.940 3.107 0.554
ENSG00000114650 E010 40.850376 0.0005345276 3.200690e-04 1.461147e-03 3 47417824 47417826 3 - 1.393 1.642 0.854
ENSG00000114650 E011 432.697533 0.0011211821 1.149839e-01 2.128112e-01 3 47418134 47418249 116 - 2.555 2.616 0.203
ENSG00000114650 E012 586.881953 0.0026163717 1.065918e-02 3.035476e-02 3 47418321 47418522 202 - 2.659 2.759 0.334
ENSG00000114650 E013 782.735502 0.0001426295 9.251384e-04 3.703036e-03 3 47418655 47418843 189 - 2.803 2.873 0.231
ENSG00000114650 E014 601.164467 0.0002049880 3.248895e-01 4.683051e-01 3 47419328 47419384 57 - 2.735 2.740 0.015
ENSG00000114650 E015 1129.047783 0.0001914614 6.005146e-05 3.316977e-04 3 47419385 47419704 320 - 3.032 3.003 -0.097
ENSG00000114650 E016 431.018333 0.0001758276 5.656474e-03 1.770482e-02 3 47420554 47420618 65 - 2.616 2.585 -0.106
ENSG00000114650 E017 388.038978 0.0003212832 5.278485e-06 3.736337e-05 3 47420619 47420653 35 - 2.598 2.525 -0.242
ENSG00000114650 E018 623.921001 0.0012258196 9.097335e-04 3.648158e-03 3 47420654 47420772 119 - 2.790 2.740 -0.166
ENSG00000114650 E019 614.874050 0.0008266254 1.550838e-06 1.235499e-05 3 47420931 47421029 99 - 2.799 2.725 -0.245
ENSG00000114650 E020 10.525026 0.0077347988 8.305116e-02 1.643289e-01 3 47421030 47421365 336 - 1.145 0.978 -0.611
ENSG00000114650 E021 581.516747 0.0008753384 1.341089e-07 1.329489e-06 3 47422442 47422536 95 - 2.783 2.697 -0.287
ENSG00000114650 E022 19.153486 0.0284537957 3.937030e-04 1.750636e-03 3 47422537 47422793 257 - 1.484 1.115 -1.294
ENSG00000114650 E023 539.661197 0.0010723845 2.835575e-10 4.634154e-09 3 47423933 47424045 113 - 2.771 2.654 -0.390
ENSG00000114650 E024 10.461869 0.0080557971 1.214002e-05 7.909930e-05 3 47425275 47425484 210 - 1.276 0.826 -1.652
ENSG00000114650 E025 532.130622 0.0020609973 3.306010e-03 1.116563e-02 3 47425485 47425611 127 - 2.726 2.671 -0.184
ENSG00000114650 E026 642.665079 0.0013207456 2.363292e-04 1.118067e-03 3 47425997 47426169 173 - 2.809 2.750 -0.196
ENSG00000114650 E027 438.417052 0.0011162931 6.919325e-07 5.947304e-06 3 47427157 47427262 106 - 2.667 2.572 -0.317
ENSG00000114650 E028 599.709294 0.0029211906 9.701023e-06 6.469864e-05 3 47427447 47427638 192 - 2.813 2.705 -0.357
ENSG00000114650 E029 279.431197 0.0042383718 2.086724e-03 7.493007e-03 3 47427639 47427667 29 - 2.474 2.379 -0.315
ENSG00000114650 E030 257.967631 0.0037493210 4.801318e-04 2.083981e-03 3 47428513 47428525 13 - 2.447 2.340 -0.358
ENSG00000114650 E031 331.425888 0.0036625624 5.424385e-05 3.029669e-04 3 47428526 47428560 35 - 2.564 2.444 -0.400
ENSG00000114650 E032 454.838493 0.0017583886 4.605090e-09 6.045462e-08 3 47428561 47428670 110 - 2.708 2.576 -0.438
ENSG00000114650 E033 4.791044 0.0036066322 6.732435e-03 2.052823e-02 3 47428671 47429026 356 - 0.935 0.585 -1.420
ENSG00000114650 E034 1.627463 0.1713065823 5.985472e-01 7.201225e-01 3 47434853 47434924 72 - 0.446 0.347 -0.553
ENSG00000114650 E035 13.918302 0.0014949745 6.870551e-02 1.412225e-01 3 47434925 47434995 71 - 1.233 1.084 -0.533
ENSG00000114650 E036 10.449972 0.0016811454 4.391954e-02 9.824103e-02 3 47434996 47435007 12 - 1.145 0.957 -0.689
ENSG00000114650 E037 607.586374 0.0001109476 6.828095e-23 5.991487e-21 3 47435008 47435137 130 - 2.831 2.700 -0.436
ENSG00000114650 E038 531.564924 0.0017257032 9.192778e-13 2.271481e-11 3 47442872 47443091 220 - 2.790 2.633 -0.523
ENSG00000114650 E039 1.801478 0.0982932281 6.820846e-01 7.856084e-01 3 47443092 47443302 211 - 0.370 0.459 0.483
ENSG00000114650 E040 12.729282 0.0014141401 4.400726e-01 5.817895e-01 3 47466376 47466447 72 - 1.035 1.132 0.350
ENSG00000114650 E041 1.773479 0.0081327627 8.450357e-01 9.035976e-01 3 47472771 47472830 60 - 0.446 0.424 -0.113
ENSG00000114650 E042 2.872190 0.0055023218 5.989750e-02 1.264352e-01 3 47475423 47475798 376 - 0.738 0.461 -1.241
ENSG00000114650 E043 145.290991 0.0048148637 1.535340e-10 2.625141e-09 3 47475799 47476011 213 - 2.292 2.028 -0.884
ENSG00000114650 E044 0.147249 0.0429127491 2.496674e-01   3 47476939 47477126 188 - 0.161 0.000 -9.485