ENSG00000114626

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000232744 ENSG00000114626 HEK293_OSMI2_2hA HEK293_TMG_2hB ABTB1 protein_coding protein_coding 3.204083 5.831085 1.870636 0.6168503 0.0978362 -1.635016 1.1006305 2.89148015 0.54397584 0.49929992 0.32952407 -2.38889409 0.31297917 0.51526667 0.29460000 -0.22066667 6.515766e-01 5.492029e-05 FALSE  
ENST00000453791 ENSG00000114626 HEK293_OSMI2_2hA HEK293_TMG_2hB ABTB1 protein_coding protein_coding 3.204083 5.831085 1.870636 0.6168503 0.0978362 -1.635016 0.1911082 0.56306833 0.00000000 0.06633229 0.00000000 -5.84063527 0.04338750 0.09946667 0.00000000 -0.09946667 5.492029e-05 5.492029e-05 FALSE  
ENST00000464431 ENSG00000114626 HEK293_OSMI2_2hA HEK293_TMG_2hB ABTB1 protein_coding retained_intron 3.204083 5.831085 1.870636 0.6168503 0.0978362 -1.635016 0.3663620 0.27032440 0.25225007 0.02765903 0.01906608 -0.09615418 0.14329167 0.04686667 0.13653333 0.08966667 1.334125e-02 5.492029e-05 FALSE  
ENST00000466612 ENSG00000114626 HEK293_OSMI2_2hA HEK293_TMG_2hB ABTB1 protein_coding processed_transcript 3.204083 5.831085 1.870636 0.6168503 0.0978362 -1.635016 0.1400170 0.11332842 0.19472148 0.03230043 0.02426647 0.73115716 0.05586667 0.01923333 0.10330000 0.08406667 8.650220e-04 5.492029e-05    
ENST00000468137 ENSG00000114626 HEK293_OSMI2_2hA HEK293_TMG_2hB ABTB1 protein_coding protein_coding 3.204083 5.831085 1.870636 0.6168503 0.0978362 -1.635016 0.2032089 0.01796411 0.15381063 0.01796411 0.15381063 2.55038086 0.08055000 0.00340000 0.07680000 0.07340000 7.836355e-01 5.492029e-05 FALSE  
ENST00000475042 ENSG00000114626 HEK293_OSMI2_2hA HEK293_TMG_2hB ABTB1 protein_coding nonsense_mediated_decay 3.204083 5.831085 1.870636 0.6168503 0.0978362 -1.635016 0.5664990 0.97900475 0.05192463 0.49290229 0.05192463 -3.99739230 0.14652917 0.16366667 0.03090000 -0.13276667 5.889664e-01 5.492029e-05 FALSE  
ENST00000475265 ENSG00000114626 HEK293_OSMI2_2hA HEK293_TMG_2hB ABTB1 protein_coding retained_intron 3.204083 5.831085 1.870636 0.6168503 0.0978362 -1.635016 0.0355378 0.00000000 0.16955920 0.00000000 0.08638572 4.16638770 0.01650833 0.00000000 0.08606667 0.08606667 4.565289e-02 5.492029e-05    
MSTRG.23624.2 ENSG00000114626 HEK293_OSMI2_2hA HEK293_TMG_2hB ABTB1 protein_coding   3.204083 5.831085 1.870636 0.6168503 0.0978362 -1.635016 0.3975840 0.66827304 0.46204220 0.45660549 0.23763879 -0.52295032 0.13325000 0.10200000 0.24980000 0.14780000 8.128509e-01 5.492029e-05 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114626 E001 1.5457760 0.0097695581 9.957655e-02 1.898332e-01 3 127672935 127672944 10 + 0.000 0.373 10.731
ENSG00000114626 E002 1.6972914 0.0091168058 4.236232e-01 5.666785e-01 3 127672945 127672946 2 + 0.211 0.372 1.119
ENSG00000114626 E003 2.8733184 0.0073858378 3.633077e-01 5.077201e-01 3 127672947 127672951 5 + 0.615 0.457 -0.743
ENSG00000114626 E004 2.8733184 0.0073858378 3.633077e-01 5.077201e-01 3 127672952 127672957 6 + 0.615 0.457 -0.743
ENSG00000114626 E005 12.5028590 0.0051322732 5.075318e-01 6.430152e-01 3 127672958 127673013 56 + 0.960 1.041 0.298
ENSG00000114626 E006 15.4513462 0.0018559081 8.369201e-01 8.980064e-01 3 127673014 127673033 20 + 1.130 1.109 -0.077
ENSG00000114626 E007 19.1339956 0.0010715620 7.268959e-01 8.197993e-01 3 127673034 127673081 48 + 1.169 1.202 0.117
ENSG00000114626 E008 1.2793957 0.2538687571 4.736050e-02 1.044725e-01 3 127673082 127673305 224 + 0.615 0.180 -2.607
ENSG00000114626 E009 0.4741261 0.0222110162 9.417584e-02 1.816614e-01 3 127673306 127673383 78 + 0.352 0.068 -2.883
ENSG00000114626 E010 1.3338852 0.0106087324 1.303133e-02 3.598495e-02 3 127673384 127673608 225 + 0.616 0.179 -2.619
ENSG00000114626 E011 1.2962207 0.0115960215 1.321177e-02 3.640521e-02 3 127674110 127674344 235 + 0.616 0.179 -2.620
ENSG00000114626 E012 2.9346544 0.0154487567 8.409645e-01 9.007593e-01 3 127674345 127674390 46 + 0.544 0.506 -0.182
ENSG00000114626 E013 18.5449875 0.0010973234 5.249977e-01 6.584158e-01 3 127674391 127674418 28 + 1.130 1.192 0.221
ENSG00000114626 E014 14.1908151 0.0012983629 9.350957e-01 9.631379e-01 3 127674419 127674453 35 + 1.065 1.074 0.030
ENSG00000114626 E015 20.4101639 0.0010124236 1.094572e-01 2.047669e-01 3 127674545 127674600 56 + 1.088 1.246 0.562
ENSG00000114626 E016 0.1515154 0.0425051257 1.199749e-01   3 127674601 127674601 1 + 0.211 0.000 -13.869
ENSG00000114626 E017 1.1436611 0.0161742252 5.372643e-03 1.694239e-02 3 127675486 127675969 484 + 0.615 0.127 -3.204
ENSG00000114626 E018 23.9542337 0.0194244647 1.840942e-01 3.063660e-01 3 127675970 127676084 115 + 1.150 1.309 0.562
ENSG00000114626 E019 20.6706811 0.0113481495 2.569336e-01 3.939565e-01 3 127676085 127676114 30 + 1.110 1.238 0.456
ENSG00000114626 E020 0.3332198 0.0285201715 3.434050e-01   3 127676115 127676271 157 + 0.211 0.068 -1.883
ENSG00000114626 E021 37.0781436 0.0006571328 5.017522e-01 6.379003e-01 3 127676272 127676431 160 + 1.425 1.472 0.161
ENSG00000114626 E022 0.0000000       3 127676432 127676435 4 +      
ENSG00000114626 E023 21.1530833 0.0234466814 9.204608e-01 9.537951e-01 3 127676536 127676581 46 + 1.237 1.243 0.023
ENSG00000114626 E024 4.3258882 0.0781171638 5.421579e-03 1.707384e-02 3 127676582 127676966 385 + 0.988 0.486 -2.081
ENSG00000114626 E025 13.1215429 0.0580974322 8.924193e-01 9.352530e-01 3 127676967 127676971 5 + 1.041 1.052 0.038
ENSG00000114626 E026 25.2401274 0.0047190264 4.249823e-01 5.679312e-01 3 127676972 127677083 112 + 1.252 1.322 0.246
ENSG00000114626 E027 1.2533568 0.0112419693 6.574799e-01 7.668291e-01 3 127677084 127677167 84 + 0.352 0.267 -0.560
ENSG00000114626 E028 14.9917125 0.0012859543 9.646274e-02 1.850496e-01 3 127677168 127677176 9 + 0.929 1.121 0.702
ENSG00000114626 E029 30.5427998 0.0007126932 3.229282e-01 4.662869e-01 3 127677177 127677286 110 + 1.322 1.399 0.267
ENSG00000114626 E030 25.9788118 0.0008021709 9.723576e-01 9.867542e-01 3 127677465 127677563 99 + 1.322 1.319 -0.013
ENSG00000114626 E031 4.7920576 0.0094222424 7.128911e-02 1.454636e-01 3 127677564 127677675 112 + 0.860 0.590 -1.112
ENSG00000114626 E032 32.1310351 0.0009335802 2.862921e-02 6.926754e-02 3 127677676 127677806 131 + 1.525 1.372 -0.527
ENSG00000114626 E033 21.4198564 0.0009273725 9.104088e-01 9.470348e-01 3 127677807 127677843 37 + 1.252 1.241 -0.038
ENSG00000114626 E034 17.7048658 0.0011440802 1.127186e-07 1.134233e-06 3 127677844 127679572 1729 + 1.483 1.041 -1.555
ENSG00000114626 E035 2.7439713 0.0170081472 9.238604e-06 6.189793e-05 3 127679573 127679679 107 + 0.960 0.266 -3.266
ENSG00000114626 E036 5.3842163 0.0031062216 1.615559e-04 7.986845e-04 3 127679680 127679984 305 + 1.065 0.569 -1.971
ENSG00000114626 E037 46.3925779 0.0230423252 1.962342e-01 3.215180e-01 3 127679985 127680185 201 + 1.465 1.586 0.414
ENSG00000114626 E038 53.2370012 0.0005433862 1.609288e-02 4.294410e-02 3 127680269 127680528 260 + 1.500 1.647 0.502
ENSG00000114626 E039 32.1268571 0.0007317450 5.969042e-03 1.852532e-02 3 127680529 127680926 398 + 1.221 1.446 0.785
ENSG00000114626 E040 0.6642364 0.0264365996 2.129400e-01 3.419962e-01 3 127682122 127682285 164 + 0.352 0.127 -1.883