ENSG00000114554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393409 ENSG00000114554 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA1 protein_coding protein_coding 27.68681 39.1095 21.47036 4.103163 0.8168233 -0.8648698 2.298963 1.649299 4.645471 0.5536203 0.8996097 1.48835337 0.0950375 0.04016667 0.2141333 0.1739667 1.099479e-05 8.895441e-36 FALSE TRUE
ENST00000505278 ENSG00000114554 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA1 protein_coding processed_transcript 27.68681 39.1095 21.47036 4.103163 0.8168233 -0.8648698 7.502252 19.964925 0.000000 2.0846151 0.0000000 -10.96397440 0.2049792 0.51553333 0.0000000 -0.5155333 8.895441e-36 8.895441e-36 FALSE FALSE
MSTRG.23618.2 ENSG00000114554 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA1 protein_coding   27.68681 39.1095 21.47036 4.103163 0.8168233 -0.8648698 16.660699 16.605388 15.940219 2.4906004 0.1896105 -0.05894374 0.6570667 0.42366667 0.7449000 0.3212333 1.599338e-04 8.895441e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114554 E001 0.7406253 0.0156665659 7.743408e-03 2.313321e-02 3 126982693 126982709 17 + 0.432 0.000 -20.432
ENSG00000114554 E002 0.9620705 0.0122027189 4.575824e-02 1.015922e-01 3 126982710 126982740 31 + 0.432 0.118 -2.454
ENSG00000114554 E003 12.9246596 0.0024111413 5.406735e-08 5.785314e-07 3 126983115 126983287 173 + 1.331 0.877 -1.646
ENSG00000114554 E004 471.9085569 0.0051071848 7.237661e-12 1.541834e-10 3 126988521 126989787 1267 + 2.757 2.587 -0.565
ENSG00000114554 E005 154.2110405 0.0082485012 5.354839e-05 2.994976e-04 3 126991384 126991566 183 + 2.251 2.125 -0.421
ENSG00000114554 E006 134.1876301 0.0160106792 6.827357e-04 2.835830e-03 3 127003330 127003470 141 + 2.202 2.057 -0.485
ENSG00000114554 E007 98.7708244 0.0244403758 8.354727e-03 2.467808e-02 3 127004611 127004711 101 + 2.064 1.932 -0.444
ENSG00000114554 E008 96.5065477 0.0222451464 2.372333e-03 8.375538e-03 3 127004885 127005008 124 + 2.067 1.909 -0.531
ENSG00000114554 E009 126.9306633 0.0025744137 1.107085e-06 9.103432e-06 3 127005090 127005243 154 + 2.159 2.045 -0.381
ENSG00000114554 E010 125.9523055 0.0006398175 1.384034e-07 1.368982e-06 3 127006079 127006178 100 + 2.147 2.047 -0.335
ENSG00000114554 E011 142.9430440 0.0021313981 1.980116e-06 1.541829e-05 3 127007799 127007913 115 + 2.202 2.104 -0.328
ENSG00000114554 E012 206.1796409 0.0008250799 1.652736e-10 2.810646e-09 3 127011958 127012158 201 + 2.361 2.259 -0.340
ENSG00000114554 E013 124.4014439 0.0100569117 3.938818e-04 1.751184e-03 3 127014020 127014116 97 + 2.156 2.033 -0.411
ENSG00000114554 E014 138.4774577 0.0075835402 5.675680e-04 2.412314e-03 3 127014182 127014375 194 + 2.188 2.094 -0.314
ENSG00000114554 E015 152.3836905 0.0002410972 1.376126e-08 1.653472e-07 3 127014478 127014629 152 + 2.224 2.134 -0.301
ENSG00000114554 E016 144.7354080 0.0002565790 2.876192e-08 3.249752e-07 3 127014711 127014831 121 + 2.202 2.111 -0.303
ENSG00000114554 E017 173.7368266 0.0017968425 9.193734e-06 6.163436e-05 3 127015184 127015320 137 + 2.274 2.202 -0.240
ENSG00000114554 E018 208.9451763 0.0010495750 1.881248e-05 1.174057e-04 3 127016517 127016684 168 + 2.339 2.293 -0.152
ENSG00000114554 E019 169.9608477 0.0009598031 1.790648e-06 1.407605e-05 3 127016944 127017037 94 + 2.261 2.192 -0.231
ENSG00000114554 E020 254.4886368 0.0020857472 1.741285e-03 6.412309e-03 3 127017425 127017664 240 + 2.406 2.390 -0.054
ENSG00000114554 E021 226.5341233 0.0007175742 1.988320e-04 9.588178e-04 3 127017749 127017892 144 + 2.358 2.336 -0.073
ENSG00000114554 E022 277.5082679 0.0003247351 1.135307e-07 1.141737e-06 3 127018294 127018528 235 + 2.457 2.413 -0.145
ENSG00000114554 E023 218.5249352 0.0003393103 3.732023e-04 1.670259e-03 3 127020202 127020344 143 + 2.336 2.322 -0.045
ENSG00000114554 E024 258.9375757 0.0001772358 2.117866e-01 3.405883e-01 3 127022085 127022341 257 + 2.374 2.422 0.159
ENSG00000114554 E025 131.4414314 0.0002699029 3.258579e-01 4.692993e-01 3 127022752 127022818 67 + 2.085 2.130 0.149
ENSG00000114554 E026 7.1266649 0.0035049690 8.052407e-02 1.603701e-01 3 127026385 127027939 1555 + 0.979 0.839 -0.529
ENSG00000114554 E027 225.7504806 0.0001870294 1.809060e-03 6.627877e-03 3 127027940 127028086 147 + 2.343 2.344 0.001
ENSG00000114554 E028 271.4689585 0.0017957189 3.009909e-02 7.215321e-02 3 127028181 127028340 160 + 2.414 2.432 0.059
ENSG00000114554 E029 4.5920341 0.2560839395 5.171923e-01 6.516309e-01 3 127028777 127028992 216 + 0.763 0.703 -0.247
ENSG00000114554 E030 211.7440946 0.0010758527 9.498618e-01 9.726419e-01 3 127028993 127029096 104 + 2.269 2.346 0.258
ENSG00000114554 E031 227.0405164 0.0002222345 9.333175e-01 9.619767e-01 3 127029440 127029536 97 + 2.298 2.376 0.261
ENSG00000114554 E032 331.5077136 0.0001445957 4.229367e-01 5.660719e-01 3 127029874 127030064 191 + 2.474 2.535 0.200
ENSG00000114554 E033 348.1810206 0.0008369253 1.063749e-01 2.001924e-01 3 127030243 127030412 170 + 2.508 2.549 0.139
ENSG00000114554 E034 0.7416549 0.0592598977 7.956262e-01 8.694967e-01 3 127031855 127031961 107 + 0.226 0.211 -0.122
ENSG00000114554 E035 428.8679395 0.0001399925 9.454614e-01 9.697714e-01 3 127032387 127032599 213 + 2.576 2.653 0.258
ENSG00000114554 E036 315.2292840 0.0007079820 4.618737e-02 1.023830e-01 3 127032686 127032836 151 + 2.414 2.539 0.416
ENSG00000114554 E037 2984.2030707 0.0061103622 2.975265e-19 1.743982e-17 3 127033922 127037389 3468 + 3.247 3.585 1.126