ENSG00000114544

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315891 ENSG00000114544 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A3 protein_coding protein_coding 29.51175 38.35104 24.41585 2.62347 1.134585 -0.6512327 2.927253 0.000000 5.394072 0.0000000 1.2039888 9.0779032 0.10580833 0.00000000 0.21796667 0.21796667 1.798863e-25 1.798863e-25 FALSE TRUE
ENST00000346785 ENSG00000114544 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A3 protein_coding protein_coding 29.51175 38.35104 24.41585 2.62347 1.134585 -0.6512327 1.506881 5.387338 1.200827 0.5522118 0.6242474 -2.1562546 0.04684583 0.13990000 0.05146667 -0.08843333 5.003559e-01 1.798863e-25 FALSE TRUE
ENST00000360370 ENSG00000114544 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A3 protein_coding protein_coding 29.51175 38.35104 24.41585 2.62347 1.134585 -0.6512327 19.999620 28.729218 12.665506 1.2323931 0.8425893 -1.1809775 0.67158333 0.75210000 0.52306667 -0.22903333 4.809680e-03 1.798863e-25 FALSE TRUE
MSTRG.23609.7 ENSG00000114544 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A3 protein_coding   29.51175 38.35104 24.41585 2.62347 1.134585 -0.6512327 2.558115 2.070231 1.635799 0.4002238 0.9400252 -0.3379555 0.08743333 0.05323333 0.06463333 0.01140000 9.928721e-01 1.798863e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114544 E001 1.6479881 0.0092835082 6.788949e-01 7.832563e-01 3 126006357 126006357 1 - 0.449 0.381 -0.365
ENSG00000114544 E002 3.0045987 0.0119785531 6.057171e-01 7.260570e-01 3 126006358 126006362 5 - 0.513 0.607 0.428
ENSG00000114544 E003 3.0077192 0.0072778483 2.977176e-01 4.390639e-01 3 126006363 126006372 10 - 0.449 0.631 0.856
ENSG00000114544 E004 17.6341092 0.0315441791 4.309926e-01 5.735880e-01 3 126006373 126006423 51 - 1.163 1.266 0.362
ENSG00000114544 E005 189.2996298 0.0104667857 3.206251e-03 1.087349e-02 3 126006424 126006564 141 - 2.109 2.289 0.600
ENSG00000114544 E006 141.2239714 0.0068081599 3.024279e-05 1.798081e-04 3 126006565 126006628 64 - 1.942 2.173 0.776
ENSG00000114544 E007 183.9286733 0.0013086577 7.151026e-13 1.796261e-11 3 126006629 126006716 88 - 2.032 2.292 0.869
ENSG00000114544 E008 243.4568574 0.0010151683 3.283919e-10 5.308265e-09 3 126006717 126006855 139 - 2.205 2.400 0.652
ENSG00000114544 E009 352.9634987 0.0020631956 1.805185e-07 1.745098e-06 3 126006856 126007113 258 - 2.389 2.554 0.550
ENSG00000114544 E010 284.6691536 0.0001628346 2.379154e-02 5.938465e-02 3 126007114 126007225 112 - 2.371 2.432 0.203
ENSG00000114544 E011 340.4442988 0.0001454788 4.240996e-01 5.670916e-01 3 126008732 126008880 149 - 2.498 2.490 -0.024
ENSG00000114544 E012 327.4410552 0.0001677027 1.736532e-01 2.929365e-01 3 126012615 126012749 135 - 2.490 2.471 -0.064
ENSG00000114544 E013 261.9096384 0.0001890088 1.193273e-01 2.189781e-01 3 126015494 126015573 80 - 2.397 2.369 -0.091
ENSG00000114544 E014 242.7184815 0.0017518415 2.475865e-02 6.138049e-02 3 126016731 126016783 53 - 2.384 2.326 -0.193
ENSG00000114544 E015 259.9040989 0.0010742952 2.837188e-02 6.875402e-02 3 126016784 126016875 92 - 2.408 2.358 -0.165
ENSG00000114544 E016 169.7760417 0.0002453262 9.552001e-01 9.758822e-01 3 126022786 126022821 36 - 2.182 2.193 0.036
ENSG00000114544 E017 248.8646120 0.0002057634 2.942047e-01 4.353010e-01 3 126022822 126022932 111 - 2.367 2.350 -0.054
ENSG00000114544 E018 40.0834101 0.0007176405 1.674221e-13 4.617500e-12 3 126022933 126024802 1870 - 1.814 1.416 -1.359
ENSG00000114544 E019 5.7186958 0.0328130900 3.434909e-02 8.042979e-02 3 126024803 126024905 103 - 0.982 0.677 -1.195
ENSG00000114544 E020 18.1517439 0.0018772643 4.230902e-08 4.631257e-07 3 126024906 126025790 885 - 1.496 1.062 -1.523
ENSG00000114544 E021 2.6032660 0.1266869846 1.265366e-02 3.509703e-02 3 126026303 126026328 26 - 0.810 0.291 -2.514
ENSG00000114544 E022 3.1160862 0.2093948162 1.255749e-01 2.279654e-01 3 126026329 126026334 6 - 0.778 0.437 -1.528
ENSG00000114544 E023 154.5892275 0.0002434799 5.695992e-01 6.961455e-01 3 126026335 126026383 49 - 2.131 2.158 0.089
ENSG00000114544 E024 113.8615126 0.0003021907 1.936871e-01 3.184144e-01 3 126026384 126026392 9 - 1.980 2.036 0.189
ENSG00000114544 E025 127.4153379 0.0002663221 8.398944e-01 9.000219e-01 3 126026393 126026411 19 - 2.057 2.073 0.053
ENSG00000114544 E026 162.0180265 0.0002476359 7.040610e-01 8.026662e-01 3 126026412 126026479 68 - 2.172 2.169 -0.008
ENSG00000114544 E027 0.6590396 0.0285973899 9.756030e-02 1.867662e-01 3 126033604 126033606 3 - 0.372 0.092 -2.531
ENSG00000114544 E028 129.3691266 0.0002720059 1.421523e-02 3.871469e-02 3 126033607 126033644 38 - 2.121 2.049 -0.240
ENSG00000114544 E029 147.1994904 0.0003093021 1.287480e-04 6.534389e-04 3 126033645 126033678 34 - 2.202 2.093 -0.364
ENSG00000114544 E030 6.2721701 0.0252575293 7.963525e-01 8.700044e-01 3 126050898 126050942 45 - 0.777 0.825 0.193
ENSG00000114544 E031 192.3885077 0.0007327083 2.043555e-06 1.586402e-05 3 126050943 126051050 108 - 2.329 2.202 -0.425
ENSG00000114544 E032 0.8448967 0.2834971446 4.048002e-01 5.484936e-01 3 126056358 126056513 156 - 0.372 0.170 -1.504
ENSG00000114544 E033 0.3299976 0.0274424043 4.549302e-01   3 126056514 126056838 325 - 0.000 0.167 10.058
ENSG00000114544 E034 0.9858280 0.0557571126 9.939764e-01 1.000000e+00 3 126067486 126067586 101 - 0.280 0.287 0.049
ENSG00000114544 E035 131.4174011 0.0004111848 2.011701e-05 1.246886e-04 3 126067947 126067962 16 - 2.166 2.036 -0.437
ENSG00000114544 E036 317.3231211 0.0009366908 2.548009e-05 1.541837e-04 3 126067963 126068246 284 - 2.524 2.431 -0.310
ENSG00000114544 E037 0.0000000       3 126070201 126070416 216 -      
ENSG00000114544 E038 0.4847352 0.2270552175 3.132770e-01 4.558389e-01 3 126073153 126073269 117 - 0.280 0.092 -1.951
ENSG00000114544 E039 0.0000000       3 126078974 126079034 61 -      
ENSG00000114544 E040 1.3360607 0.5153526269 5.897616e-01 7.127956e-01 3 126083876 126083928 53 - 0.374 0.307 -0.409
ENSG00000114544 E041 2.5109826 0.0120197943 1.296086e-01 2.336047e-01 3 126083929 126084053 125 - 0.665 0.422 -1.141
ENSG00000114544 E042 0.1817044 0.0397675501 1.000000e+00   3 126084054 126084092 39 - 0.000 0.091 9.048
ENSG00000114544 E043 98.8147080 0.0020711688 3.427339e-01 4.867567e-01 3 126084093 126084304 212 - 1.978 1.947 -0.105
ENSG00000114544 E044 0.0000000       3 126101429 126101561 133 -