ENSG00000114529

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264848 ENSG00000114529 HEK293_OSMI2_2hA HEK293_TMG_2hB C3orf52 protein_coding protein_coding 10.51022 7.811842 12.56166 1.20039 0.1575924 0.6845946 8.5978853 7.0496511 9.7134454 1.23933039 0.4293039 0.4618707 0.82137083 0.8964667 0.77270000 -0.123766667 0.02017786 0.02017786 FALSE TRUE
ENST00000431717 ENSG00000114529 HEK293_OSMI2_2hA HEK293_TMG_2hB C3orf52 protein_coding protein_coding 10.51022 7.811842 12.56166 1.20039 0.1575924 0.6845946 0.6994965 0.4602148 0.6798163 0.09374674 0.2179904 0.5528922 0.06961667 0.0606000 0.05433333 -0.006266667 0.90722597 0.02017786 FALSE TRUE
MSTRG.23426.3 ENSG00000114529 HEK293_OSMI2_2hA HEK293_TMG_2hB C3orf52 protein_coding   10.51022 7.811842 12.56166 1.20039 0.1575924 0.6845946 0.7013293 0.1292253 1.4137402 0.07451389 0.1980324 3.3541926 0.05968750 0.0190000 0.11276667 0.093766667 0.05829260 0.02017786 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114529 E001 0.7331366 0.0172060497 0.3091825037 0.4514506279 3 112086335 112086364 30 + 0.313 0.146 -1.396
ENSG00000114529 E002 4.3534401 0.0037069516 0.1508811196 0.2628653253 3 112086365 112086388 24 + 0.798 0.624 -0.717
ENSG00000114529 E003 31.4000977 0.0103256937 0.2973367572 0.4386592997 3 112086389 112086436 48 + 1.534 1.484 -0.171
ENSG00000114529 E004 30.9582369 0.0129303083 0.3953054271 0.5391219296 3 112086437 112086437 1 + 1.524 1.484 -0.138
ENSG00000114529 E005 55.2320902 0.0007977036 0.0166675206 0.0442093943 3 112086438 112086545 108 + 1.784 1.709 -0.256
ENSG00000114529 E006 72.7625525 0.0004330448 0.0156896816 0.0420407218 3 112093360 112093489 130 + 1.897 1.837 -0.199
ENSG00000114529 E007 68.8695749 0.0004317160 0.0095073542 0.0275559526 3 112102838 112102965 128 + 1.876 1.806 -0.235
ENSG00000114529 E008 61.6833562 0.0004244943 0.1305888507 0.2349758373 3 112109543 112109613 71 + 1.814 1.786 -0.092
ENSG00000114529 E009 0.7320925 0.0450967957 0.0467539491 0.1033872841 3 112109614 112109828 215 + 0.365 0.000 -12.002
ENSG00000114529 E010 0.0000000       3 112111452 112111453 2 +      
ENSG00000114529 E011 0.6955713 0.0180741381 0.7388583729 0.8286339386 3 112111454 112111780 327 + 0.184 0.256 0.608
ENSG00000114529 E012 0.1451727 0.0436932542 0.6858712118   3 112111892 112112074 183 + 0.102 0.000 -9.741
ENSG00000114529 E013 0.4460135 0.0257682512 0.1554767669 0.2690257705 3 112112339 112112459 121 + 0.253 0.000 -11.313
ENSG00000114529 E014 86.4523936 0.0003984311 0.2185854489 0.3487217368 3 112112964 112113145 182 + 1.949 1.943 -0.021
ENSG00000114529 E015 88.2719145 0.0031401133 0.6028418381 0.7237363620 3 112116642 112116867 226 + 1.925 1.981 0.190
ENSG00000114529 E016 44.6171600 0.0005559369 0.1757660421 0.2956856997 3 112116868 112116906 39 + 1.608 1.716 0.365
ENSG00000114529 E017 329.6072627 0.0066348979 0.0001517662 0.0007547949 3 112116907 112118226 1320 + 2.446 2.597 0.502
ENSG00000114529 E018 3.0916602 0.0076395770 0.6721584626 0.7782331812 3 112119469 112119562 94 + 0.620 0.581 -0.170
ENSG00000114529 E019 2.6185663 0.0066507062 0.3959540244 0.5397422761 3 112119563 112119641 79 + 0.591 0.478 -0.530
ENSG00000114529 E020 28.3203646 0.0197561702 0.0049494877 0.0157909329 3 112128233 112130896 2664 + 1.554 1.310 -0.844
ENSG00000114529 E021 4.2586320 0.0112237883 0.0714610593 0.1457651418 3 112130897 112131004 108 + 0.816 0.580 -0.983
ENSG00000114529 E022 0.3289534 0.0299106114 0.8064540714   3 112139943 112139981 39 + 0.102 0.147 0.606