ENSG00000114491

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000232607 ENSG00000114491 HEK293_OSMI2_2hA HEK293_TMG_2hB UMPS protein_coding protein_coding 43.41272 25.20457 59.57262 3.378864 2.214958 1.240634 10.408100 9.422498 13.789117 1.093345 0.2515269 0.5488643 0.2628458 0.3760000 0.2319000 -0.14410000 1.645310e-09 1.64531e-09 FALSE TRUE
ENST00000487622 ENSG00000114491 HEK293_OSMI2_2hA HEK293_TMG_2hB UMPS protein_coding retained_intron 43.41272 25.20457 59.57262 3.378864 2.214958 1.240634 6.686014 3.486787 6.758766 1.269407 0.8915544 0.9528627 0.1562000 0.1310000 0.1127000 -0.01830000 8.787630e-01 1.64531e-09 FALSE TRUE
ENST00000498715 ENSG00000114491 HEK293_OSMI2_2hA HEK293_TMG_2hB UMPS protein_coding processed_transcript 43.41272 25.20457 59.57262 3.378864 2.214958 1.240634 14.764044 9.006737 18.399212 1.943695 0.8684489 1.0297505 0.3373417 0.3485667 0.3087333 -0.03983333 6.871580e-01 1.64531e-09 FALSE TRUE
ENST00000628619 ENSG00000114491 HEK293_OSMI2_2hA HEK293_TMG_2hB UMPS protein_coding protein_coding 43.41272 25.20457 59.57262 3.378864 2.214958 1.240634 10.274148 2.280340 19.216948 1.140592 0.3936045 3.0694963 0.2100125 0.1041333 0.3229667 0.21883333 4.862906e-01 1.64531e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114491 E001 1.7726255 0.0138595015 8.003781e-02 1.596114e-01 3 124730421 124730427 7 + 0.554 0.241 -1.800
ENSG00000114491 E002 2.5142949 0.0155455893 4.194030e-02 9.462039e-02 3 124730428 124730432 5 + 0.674 0.324 -1.747
ENSG00000114491 E003 4.8298409 0.0780425493 7.309997e-01 8.227525e-01 3 124730433 124730444 12 + 0.789 0.712 -0.312
ENSG00000114491 E004 14.8982854 0.0122420059 7.357922e-01 8.264722e-01 3 124730445 124730451 7 + 1.217 1.178 -0.137
ENSG00000114491 E005 234.3649495 0.0035200101 7.143408e-07 6.123240e-06 3 124730452 124730627 176 + 2.454 2.265 -0.630
ENSG00000114491 E006 8.7538081 0.0018800673 1.523802e-02 4.102547e-02 3 124731506 124731604 99 + 1.106 0.839 -0.992
ENSG00000114491 E007 341.0813806 0.0019219822 1.201649e-04 6.147186e-04 3 124735093 124735246 154 + 2.587 2.476 -0.371
ENSG00000114491 E008 0.5964967 0.0212326003 4.441663e-01 5.857422e-01 3 124737195 124737222 28 + 0.270 0.136 -1.221
ENSG00000114491 E009 571.7628707 0.0002797113 3.035731e-03 1.037094e-02 3 124737568 124737914 347 + 2.784 2.739 -0.149
ENSG00000114491 E010 395.9373550 0.0002025262 8.478278e-01 9.055098e-01 3 124737915 124738130 216 + 2.603 2.610 0.021
ENSG00000114491 E011 294.9923618 0.0005348065 3.653600e-01 5.096708e-01 3 124738131 124738239 109 + 2.487 2.470 -0.055
ENSG00000114491 E012 7.8635981 0.0140231288 3.298161e-04 1.500076e-03 3 124738240 124738443 204 + 1.115 0.636 -1.857
ENSG00000114491 E013 3.7999090 0.0041060742 6.419972e-04 2.687352e-03 3 124738625 124738735 111 + 0.864 0.324 -2.508
ENSG00000114491 E014 442.8973018 0.0027941067 1.457114e-01 2.558159e-01 3 124740024 124740199 176 + 2.631 2.673 0.141
ENSG00000114491 E015 385.9721168 0.0032289058 4.571405e-02 1.015096e-01 3 124742152 124742266 115 + 2.559 2.625 0.218
ENSG00000114491 E016 6.0612389 0.0029008112 5.636062e-01 6.910593e-01 3 124742267 124742665 399 + 0.809 0.884 0.289
ENSG00000114491 E017 1282.7825879 0.0001711308 6.683312e-10 1.024463e-08 3 124743915 124749273 5359 + 3.085 3.143 0.191