ENSG00000114473

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265239 ENSG00000114473 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCG protein_coding protein_coding 2.687658 1.72133 3.716408 0.09949618 0.2617242 1.105905 0.2160164 0.19434836 0.39913820 0.09776162 0.06381389 1.001558 0.08376667 0.10966667 0.106200000 -0.003466667 1.00000000 0.02242005 FALSE  
ENST00000455191 ENSG00000114473 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCG protein_coding protein_coding 2.687658 1.72133 3.716408 0.09949618 0.2617242 1.105905 1.8608824 1.19152635 2.47025852 0.07444257 0.21531563 1.045622 0.68182500 0.70063333 0.677933333 -0.022700000 0.99240623 0.02242005 FALSE  
ENST00000463651 ENSG00000114473 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCG protein_coding processed_transcript 2.687658 1.72133 3.716408 0.09949618 0.2617242 1.105905 0.1689703 0.00000000 0.35071928 0.00000000 0.35071928 5.172805 0.05507917 0.00000000 0.082733333 0.082733333 0.92873931 0.02242005    
ENST00000469822 ENSG00000114473 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCG protein_coding processed_transcript 2.687658 1.72133 3.716408 0.09949618 0.2617242 1.105905 0.1675647 0.10495764 0.11227016 0.10495764 0.04276646 0.088970 0.06559167 0.05480000 0.030700000 -0.024100000 0.96327450 0.02242005    
ENST00000478903 ENSG00000114473 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCG protein_coding retained_intron 2.687658 1.72133 3.716408 0.09949618 0.2617242 1.105905 0.0223101 0.09589772 0.01534807 0.02563719 0.01534807 -2.062724 0.01137917 0.05736667 0.003633333 -0.053733333 0.02242005 0.02242005 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114473 E001 0.5244761 0.1806805871 1.000000000 1.00000000 3 197889077 197889077 1 - 0.172 0.159 -0.134
ENSG00000114473 E002 20.1185289 0.0010738151 0.007001292 0.02122673 3 197889078 197889412 335 - 1.230 1.428 0.689
ENSG00000114473 E003 31.8467094 0.0009996953 0.024318613 0.06047159 3 197889413 197889714 302 - 1.449 1.582 0.454
ENSG00000114473 E004 14.8268388 0.0022055505 0.542119821 0.67294142 3 197891446 197891547 102 - 1.171 1.224 0.188
ENSG00000114473 E005 16.3963247 0.0059863199 0.473247433 0.61223654 3 197892628 197892759 132 - 1.205 1.267 0.220
ENSG00000114473 E006 2.3999509 0.2769148797 0.377574467 0.52189839 3 197906368 197906695 328 - 0.389 0.704 1.484
ENSG00000114473 E007 0.7426990 0.0449468007 0.117466422 0.21633431 3 197912485 197912536 52 - 0.094 0.365 2.441
ENSG00000114473 E008 13.5882832 0.0015167634 0.032646989 0.07709410 3 197912675 197912749 75 - 1.067 1.257 0.678
ENSG00000114473 E009 0.4407149 0.0230425733 0.968693454 0.98439464 3 197912750 197912853 104 - 0.172 0.157 -0.150
ENSG00000114473 E010 1.3618961 0.0108647759 0.024998733 0.06187125 3 197912854 197913284 431 - 0.172 0.559 2.436
ENSG00000114473 E011 0.2903454 0.3153406744 0.507554510   3 197913351 197913495 145 - 0.171 0.001 -8.438
ENSG00000114473 E012 1.5802233 0.0085299587 0.708688411 0.80629175 3 197913722 197913880 159 - 0.431 0.364 -0.370
ENSG00000114473 E013 16.6770778 0.0012031437 0.223910713 0.35508243 3 197913881 197914042 162 - 1.198 1.297 0.347
ENSG00000114473 E014 0.0000000       3 197916172 197916420 249 -      
ENSG00000114473 E015 10.3173136 0.0017654162 0.408087500 0.55166155 3 197926024 197926096 73 - 1.009 1.092 0.304
ENSG00000114473 E016 6.9227032 0.0026280176 0.106796088 0.20082384 3 197926097 197926105 9 - 0.965 0.764 -0.777
ENSG00000114473 E017 13.9962488 0.0013479497 0.757139030 0.84205726 3 197932174 197932302 129 - 1.178 1.150 -0.099
ENSG00000114473 E018 16.5273989 0.0011735394 0.064546237 0.13428903 3 197938548 197938659 112 - 1.293 1.136 -0.557
ENSG00000114473 E019 9.0864162 0.0031747993 0.003364164 0.01133436 3 197938660 197938665 6 - 1.110 0.764 -1.305
ENSG00000114473 E020 13.8296682 0.0016986783 0.005445707 0.01714226 3 197938666 197938775 110 - 1.254 0.989 -0.956
ENSG00000114473 E021 6.9211430 0.0038835197 0.595973351 0.71797630 3 197938776 197938780 5 - 0.917 0.852 -0.249
ENSG00000114473 E022 0.0000000       3 197938781 197939032 252 -      
ENSG00000114473 E023 0.4720498 0.1542038879 1.000000000 1.00000000 3 197943757 197943777 21 - 0.171 0.158 -0.143
ENSG00000114473 E024 16.9905502 0.0012358245 0.066655970 0.13782619 3 197943778 197943897 120 - 1.304 1.150 -0.545
ENSG00000114473 E025 20.9239616 0.0049241935 0.045099393 0.10037883 3 197943898 197944051 154 - 1.389 1.224 -0.576
ENSG00000114473 E026 10.9773378 0.0220569211 0.242327835 0.37691838 3 197945620 197945686 67 - 1.117 0.972 -0.533
ENSG00000114473 E027 0.0000000       3 197949373 197949449 77 -      
ENSG00000114473 E028 1.1050782 0.0131134238 0.698551519 0.79848489 3 197949541 197949838 298 - 0.294 0.364 0.436
ENSG00000114473 E029 6.7250897 0.0189288713 0.333918805 0.47768208 3 197949839 197949925 87 - 0.930 0.796 -0.515
ENSG00000114473 E030 0.8878717 0.0194049651 0.274048051 0.41314931 3 197956641 197959528 2888 - 0.172 0.364 1.439
ENSG00000114473 E031 4.3263822 0.0038870539 0.587834133 0.71108750 3 197959529 197959719 191 - 0.688 0.764 0.311
ENSG00000114473 E032 3.0905394 0.0056096506 0.135697167 0.24208435 3 197959845 197960015 171 - 0.502 0.730 1.003
ENSG00000114473 E033 0.6266857 0.0180267292 0.562749906 0.69030427 3 197960022 197960142 121 - 0.172 0.273 0.850