ENSG00000114439

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325805 ENSG00000114439 HEK293_OSMI2_2hA HEK293_TMG_2hB BBX protein_coding protein_coding 9.298943 1.701874 17.98994 0.1044982 0.8101944 3.394344 3.6630665 0.23305329 6.4893875 0.11734728 0.4460522 4.7409592 0.28227917 0.1296667 0.36106667 0.23140000 1.406594e-01 1.407552e-15 FALSE TRUE
ENST00000415149 ENSG00000114439 HEK293_OSMI2_2hA HEK293_TMG_2hB BBX protein_coding protein_coding 9.298943 1.701874 17.98994 0.1044982 0.8101944 3.394344 2.0233198 0.07406164 4.9583207 0.07406164 0.2664249 5.8851668 0.13759167 0.0489000 0.27570000 0.22680000 5.385267e-02 1.407552e-15 FALSE TRUE
ENST00000443253 ENSG00000114439 HEK293_OSMI2_2hA HEK293_TMG_2hB BBX protein_coding protein_coding 9.298943 1.701874 17.98994 0.1044982 0.8101944 3.394344 0.4702452 0.00000000 0.9380164 0.00000000 0.4696175 6.5668401 0.07029167 0.0000000 0.05016667 0.05016667 5.599793e-01 1.407552e-15   FALSE
ENST00000456419 ENSG00000114439 HEK293_OSMI2_2hA HEK293_TMG_2hB BBX protein_coding protein_coding 9.298943 1.701874 17.98994 0.1044982 0.8101944 3.394344 0.4372670 0.00000000 1.7317075 0.00000000 0.9185296 7.4443586 0.02571250 0.0000000 0.09853333 0.09853333 5.045907e-01 1.407552e-15 FALSE FALSE
ENST00000458347 ENSG00000114439 HEK293_OSMI2_2hA HEK293_TMG_2hB BBX protein_coding protein_coding 9.298943 1.701874 17.98994 0.1044982 0.8101944 3.394344 0.4428976 0.95435481 0.0000000 0.21486960 0.0000000 -6.5914921 0.22389583 0.5590667 0.00000000 -0.55906667 1.407552e-15 1.407552e-15 FALSE FALSE
MSTRG.23382.10 ENSG00000114439 HEK293_OSMI2_2hA HEK293_TMG_2hB BBX protein_coding   9.298943 1.701874 17.98994 0.1044982 0.8101944 3.394344 0.2518768 0.10192604 0.2401226 0.10192604 0.1313665 1.1600899 0.05020417 0.0673000 0.01273333 -0.05456667 9.795305e-01 1.407552e-15 FALSE TRUE
MSTRG.23382.15 ENSG00000114439 HEK293_OSMI2_2hA HEK293_TMG_2hB BBX protein_coding   9.298943 1.701874 17.98994 0.1044982 0.8101944 3.394344 0.3236606 0.26981461 0.2289846 0.26981461 0.2289846 -0.2275534 0.07677917 0.1573000 0.01270000 -0.14460000 7.476149e-01 1.407552e-15 FALSE TRUE
MSTRG.23382.4 ENSG00000114439 HEK293_OSMI2_2hA HEK293_TMG_2hB BBX protein_coding   9.298943 1.701874 17.98994 0.1044982 0.8101944 3.394344 0.7104623 0.00000000 1.2227433 0.00000000 0.2870118 6.9457286 0.05268333 0.0000000 0.06963333 0.06963333 8.097243e-03 1.407552e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114439 E001 0.2987644 0.0274779274 1.000000e+00   3 107522936 107522960 25 + 0.058 0.000 -29.631
ENSG00000114439 E002 0.2987644 0.0274779274 1.000000e+00   3 107522961 107522961 1 + 0.058 0.000 -29.618
ENSG00000114439 E003 0.2987644 0.0274779274 1.000000e+00   3 107522962 107522965 4 + 0.058 0.000 -29.618
ENSG00000114439 E004 2.2487287 0.0066976612 5.252309e-01 6.586359e-01 3 107522966 107522985 20 + 0.286 0.598 1.671
ENSG00000114439 E005 5.0668738 0.0309730820 9.349619e-01 9.630637e-01 3 107522986 107522990 5 + 0.508 0.735 0.998
ENSG00000114439 E006 7.6049037 0.0257895433 8.902184e-01 9.338583e-01 3 107522991 107523002 12 + 0.640 0.839 0.814
ENSG00000114439 E007 15.7113076 0.0118070934 6.824423e-02 1.404542e-01 3 107523003 107523042 40 + 0.919 0.840 -0.301
ENSG00000114439 E008 27.7166847 0.0186732532 3.800494e-03 1.258288e-02 3 107523043 107523107 65 + 1.146 0.924 -0.812
ENSG00000114439 E009 0.8952612 0.0148599357 4.952987e-01 6.321307e-01 3 107523454 107523651 198 + 0.133 0.394 2.048
ENSG00000114439 E010 0.8084787 0.1086032207 3.868172e-01 5.309782e-01 3 107524107 107524194 88 + 0.109 0.397 2.384
ENSG00000114439 E011 1.0425102 0.0121144838 5.941872e-01 7.164578e-01 3 107524357 107524567 211 + 0.155 0.394 1.785
ENSG00000114439 E012 1.6242331 0.0083403833 3.717435e-01 5.162114e-01 3 107525391 107525401 11 + 0.252 0.000 -32.078
ENSG00000114439 E013 3.4518268 0.0611279092 9.572116e-01 9.771890e-01 3 107525402 107525487 86 + 0.398 0.598 0.984
ENSG00000114439 E014 2.0898264 0.1009030989 9.202376e-01 9.536159e-01 3 107525488 107525490 3 + 0.285 0.395 0.677
ENSG00000114439 E015 41.7489284 0.0093512055 1.364051e-02 3.740433e-02 3 107526327 107526398 72 + 1.304 1.274 -0.106
ENSG00000114439 E016 0.4449813 0.0214546315 1.823493e-01 3.041649e-01 3 107526399 107526750 352 + 0.058 0.394 3.370
ENSG00000114439 E017 0.0000000       3 107599313 107599588 276 +      
ENSG00000114439 E018 0.5997190 0.1496394693 1.000000e+00 1.000000e+00 3 107638502 107638545 44 + 0.109 0.000 -30.621
ENSG00000114439 E019 1.7599546 0.1740568182 9.657786e-01 9.824749e-01 3 107641791 107641864 74 + 0.251 0.392 0.903
ENSG00000114439 E020 52.6609161 0.0096985053 1.185217e-02 3.317805e-02 3 107645836 107645909 74 + 1.399 1.393 -0.021
ENSG00000114439 E021 0.1451727 0.0431306375 5.371990e-01   3 107645910 107645929 20 + 0.030 0.000 -28.618
ENSG00000114439 E022 0.0000000       3 107645930 107645932 3 +      
ENSG00000114439 E023 0.0000000       3 107645933 107645933 1 +      
ENSG00000114439 E024 0.0000000       3 107645934 107646087 154 +      
ENSG00000114439 E025 0.0000000       3 107657062 107657172 111 +      
ENSG00000114439 E026 0.0000000       3 107659568 107659770 203 +      
ENSG00000114439 E027 1.1009004 0.0404007322 5.872682e-01 7.105844e-01 3 107661828 107661944 117 + 0.155 0.395 1.792
ENSG00000114439 E028 0.0000000       3 107662589 107662880 292 +      
ENSG00000114439 E029 0.0000000       3 107674805 107674836 32 +      
ENSG00000114439 E030 0.0000000       3 107677427 107677470 44 +      
ENSG00000114439 E031 0.0000000       3 107684556 107684709 154 +      
ENSG00000114439 E032 73.0645316 0.0028551333 5.401555e-05 3.018342e-04 3 107710452 107710622 171 + 1.541 1.442 -0.339
ENSG00000114439 E033 0.2944980 0.3827082966 1.000000e+00   3 107711275 107711364 90 + 0.058 0.000 -29.617
ENSG00000114439 E034 0.0000000       3 107716459 107716606 148 +      
ENSG00000114439 E035 79.5702936 0.0003101275 2.185344e-07 2.079392e-06 3 107716607 107716849 243 + 1.581 1.393 -0.648
ENSG00000114439 E036 76.3878425 0.0003405022 4.411368e-05 2.518823e-04 3 107728765 107728960 196 + 1.559 1.486 -0.249
ENSG00000114439 E037 41.3237895 0.0005348543 3.097758e-03 1.055353e-02 3 107732956 107733023 68 + 1.303 1.238 -0.230
ENSG00000114439 E038 45.4728917 0.0036477430 1.076425e-03 4.222846e-03 3 107744630 107744710 81 + 1.344 1.237 -0.375
ENSG00000114439 E039 45.2776772 0.0005334071 9.976095e-03 2.870506e-02 3 107747965 107748039 75 + 1.336 1.337 0.004
ENSG00000114439 E040 47.6615499 0.3723223491 2.280204e-01 3.600604e-01 3 107755598 107755678 81 + 1.352 1.431 0.273
ENSG00000114439 E041 221.7591400 0.0170744378 3.443002e-04 1.557242e-03 3 107772628 107773636 1009 + 2.009 2.016 0.024
ENSG00000114439 E042 67.8140576 0.0005061884 3.285197e-03 1.110691e-02 3 107774719 107774857 139 + 1.503 1.526 0.080
ENSG00000114439 E043 0.0000000       3 107776205 107776349 145 +      
ENSG00000114439 E044 55.2103841 0.0005782187 3.877290e-04 1.727316e-03 3 107778371 107778502 132 + 1.421 1.337 -0.293
ENSG00000114439 E045 34.1436544 0.0005924617 2.651120e-04 1.237640e-03 3 107778503 107778519 17 + 1.229 0.995 -0.844
ENSG00000114439 E046 25.4868979 0.0007665372 3.199747e-03 1.085551e-02 3 107789787 107789876 90 + 1.110 0.924 -0.681
ENSG00000114439 E047 44.1978511 0.0004743204 8.784992e-02 1.718519e-01 3 107791240 107791299 60 + 1.318 1.418 0.346
ENSG00000114439 E048 53.8424763 0.0004378353 6.615910e-03 2.022893e-02 3 107798523 107798590 68 + 1.406 1.418 0.041
ENSG00000114439 E049 36.1751012 0.0005774919 8.421145e-03 2.484095e-02 3 107798591 107798600 10 + 1.245 1.199 -0.164
ENSG00000114439 E050 72.0678921 0.0003650677 1.176961e-02 3.298251e-02 3 107798601 107798711 111 + 1.525 1.597 0.246
ENSG00000114439 E051 24.4265761 0.0007608371 4.480750e-01 5.893993e-01 3 107798712 107798720 9 + 1.072 1.238 0.593
ENSG00000114439 E052 69.7321404 0.0017148530 1.217140e-03 4.698212e-03 3 107801095 107801281 187 + 1.516 1.507 -0.033
ENSG00000114439 E053 1015.0902098 0.0460278348 1.392811e-06 1.120838e-05 3 107805370 107811339 5970 + 2.618 3.122 1.677