ENSG00000114423

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394030 ENSG00000114423 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLB protein_coding protein_coding 3.198682 2.881499 3.051568 0.2107688 0.08708938 0.08245297 0.58543758 0.5544444 0.51857213 0.02129345 0.02833509 -0.09473099 0.19125417 0.1957000 0.16980000 -0.02590000 8.369945e-01 9.726854e-07 FALSE TRUE
ENST00000407712 ENSG00000114423 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLB protein_coding retained_intron 3.198682 2.881499 3.051568 0.2107688 0.08708938 0.08245297 0.21451976 0.6892002 0.00000000 0.25853080 0.00000000 -6.12763378 0.06992083 0.2325333 0.00000000 -0.23253333 9.726854e-07 9.726854e-07 FALSE TRUE
ENST00000642241 ENSG00000114423 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLB protein_coding nonsense_mediated_decay 3.198682 2.881499 3.051568 0.2107688 0.08708938 0.08245297 0.04313589 0.2289219 0.09665894 0.15585447 0.05976999 -1.16353437 0.01566667 0.0887000 0.03246667 -0.05623333 8.621465e-01 9.726854e-07 TRUE TRUE
MSTRG.23380.3 ENSG00000114423 HEK293_OSMI2_2hA HEK293_TMG_2hB CBLB protein_coding   3.198682 2.881499 3.051568 0.2107688 0.08708938 0.08245297 1.99668965 1.2447985 2.07842789 0.28176681 0.12954084 0.73496158 0.61590000 0.4264333 0.68380000 0.25736667 9.295437e-02 9.726854e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114423 E001 42.7492180 0.0034676970 0.0377615901 0.086888853 3 105655461 105658268 2808 - 1.575 1.692 0.400
ENSG00000114423 E002 3.1980371 0.0056458562 0.1943250203 0.319183382 3 105658269 105658282 14 - 0.727 0.530 -0.859
ENSG00000114423 E003 5.0350147 0.0061162257 0.5441770462 0.674686088 3 105658283 105658330 48 - 0.752 0.832 0.320
ENSG00000114423 E004 9.8739250 0.0018629760 0.0422284539 0.095140199 3 105658331 105658404 74 - 0.926 1.135 0.765
ENSG00000114423 E005 7.8884612 0.0023143864 0.0033748195 0.011363614 3 105658405 105658414 10 - 0.752 1.089 1.278
ENSG00000114423 E006 10.8240605 0.0074304505 0.0007345653 0.003023797 3 105658415 105658440 26 - 0.857 1.222 1.338
ENSG00000114423 E007 69.3261221 0.0049514209 0.0002387318 0.001127940 3 105658441 105658949 509 - 1.744 1.929 0.622
ENSG00000114423 E008 19.3138767 0.0049157114 0.6203102514 0.737516733 3 105658950 105658954 5 - 1.325 1.282 -0.151
ENSG00000114423 E009 47.5977714 0.0006813951 0.0018229792 0.006673326 3 105658955 105659229 275 - 1.602 1.756 0.522
ENSG00000114423 E010 22.3855955 0.0009302582 0.0744003465 0.150575517 3 105670233 105670352 120 - 1.299 1.426 0.440
ENSG00000114423 E011 1.0361675 0.0117781739 0.0652839562 0.135512832 3 105670353 105671020 668 - 0.456 0.128 -2.444
ENSG00000114423 E012 0.2903454 0.3075842746 0.3138463622   3 105671021 105671023 3 - 0.209 0.000 -12.375
ENSG00000114423 E013 0.8417882 0.0160704580 0.5772813841 0.702552412 3 105671024 105671046 23 - 0.209 0.307 0.728
ENSG00000114423 E014 1.3233924 0.0108357924 0.0013993894 0.005304994 3 105671047 105672336 1290 - 0.578 0.000 -15.298
ENSG00000114423 E015 0.2924217 0.0290785164 0.2323019798   3 105672337 105672462 126 - 0.209 0.000 -13.301
ENSG00000114423 E016 1.0308569 0.0193880720 0.0057768318 0.018025257 3 105672463 105673993 1531 - 0.501 0.000 -14.961
ENSG00000114423 E017 26.0142429 0.0008635614 0.1552398782 0.268714519 3 105678431 105678571 141 - 1.384 1.478 0.322
ENSG00000114423 E018 0.1817044 0.0395569380 0.4408372522   3 105680992 105681292 301 - 0.000 0.128 11.699
ENSG00000114423 E019 1.3265088 0.1453033511 0.2562508067 0.393221499 3 105681293 105681478 186 - 0.210 0.441 1.505
ENSG00000114423 E020 17.7360183 0.0010595379 0.6026738895 0.723618896 3 105681479 105681610 132 - 1.256 1.297 0.141
ENSG00000114423 E021 0.0000000       3 105681611 105681723 113 -      
ENSG00000114423 E022 13.8203159 0.0312091330 0.8951086651 0.936970054 3 105681724 105681818 95 - 1.184 1.171 -0.046
ENSG00000114423 E023 0.2965864 0.1657204377 0.2113033938   3 105681819 105682130 312 - 0.000 0.223 12.184
ENSG00000114423 E024 20.3430815 0.0029527609 0.8513313059 0.907813587 3 105685320 105685466 147 - 1.325 1.339 0.049
ENSG00000114423 E025 16.7470312 0.0011598730 0.7078183457 0.805611668 3 105693494 105693588 95 - 1.264 1.232 -0.111
ENSG00000114423 E026 36.4022797 0.0035023145 0.0089240394 0.026090008 3 105702094 105702459 366 - 1.647 1.484 -0.558
ENSG00000114423 E027 23.9103194 0.0142394892 0.1686797752 0.286455927 3 105703988 105704173 186 - 1.456 1.333 -0.423
ENSG00000114423 E028 25.2479987 0.0180453185 0.8919835490 0.935026545 3 105720047 105720250 204 - 1.431 1.409 -0.076
ENSG00000114423 E029 0.1451727 0.0429848495 0.5419078919   3 105724026 105724189 164 - 0.117 0.000 -12.290
ENSG00000114423 E030 16.9410332 0.0013696623 0.2209752701 0.351601676 3 105734009 105734140 132 - 1.305 1.205 -0.353
ENSG00000114423 E031 14.2932069 0.0012917307 0.6312834751 0.746310472 3 105737171 105737258 88 - 1.209 1.166 -0.151
ENSG00000114423 E032 17.2047387 0.0012402585 0.4596177302 0.599723120 3 105740494 105740631 138 - 1.292 1.232 -0.211
ENSG00000114423 E033 14.7395279 0.0532684992 0.3879313366 0.532041061 3 105745917 105746038 122 - 1.249 1.152 -0.345
ENSG00000114423 E034 0.0000000       3 105749622 105749765 144 -      
ENSG00000114423 E035 10.3904152 0.0195064317 0.9187269927 0.952650522 3 105751462 105751526 65 - 1.062 1.052 -0.038
ENSG00000114423 E036 12.0548496 0.0091079475 0.8497339629 0.906753355 3 105751527 105751618 92 - 1.106 1.124 0.066
ENSG00000114423 E037 0.7727888 0.0593491585 0.6032431465 0.724068500 3 105762122 105762400 279 - 0.209 0.305 0.719
ENSG00000114423 E038 10.6149598 0.0017285375 0.1553329781 0.268843738 3 105776396 105776464 69 - 1.137 0.995 -0.515
ENSG00000114423 E039 11.7202284 0.0018194895 0.0183276497 0.047847728 3 105776465 105776521 57 - 1.209 0.980 -0.829
ENSG00000114423 E040 7.8975965 0.0039910814 0.0140707594 0.038385795 3 105776522 105776522 1 - 1.073 0.787 -1.080
ENSG00000114423 E041 9.1487527 0.0019222623 0.0051983658 0.016469869 3 105776523 105776542 20 - 1.137 0.833 -1.128
ENSG00000114423 E042 0.0000000       3 105824183 105824241 59 -      
ENSG00000114423 E043 0.0000000       3 105839423 105839470 48 -      
ENSG00000114423 E044 22.3520502 0.0009592994 0.0004682144 0.002038513 3 105853414 105853664 251 - 1.479 1.224 -0.888
ENSG00000114423 E045 11.2126515 0.0016167422 0.0140457851 0.038329255 3 105867410 105867487 78 - 1.192 0.948 -0.888
ENSG00000114423 E046 10.7279664 0.0018728056 0.1575416712 0.271844403 3 105867488 105867591 104 - 1.137 0.995 -0.515
ENSG00000114423 E047 0.1451727 0.0429848495 0.5419078919   3 105868532 105868735 204 - 0.117 0.000 -12.290
ENSG00000114423 E048 4.3784428 0.0042813660 0.4904195566 0.627760228 3 105868736 105868911 176 - 0.775 0.678 -0.398
ENSG00000114423 E049 4.8016437 0.0033818761 0.0143512549 0.039028483 3 105868912 105869044 133 - 0.910 0.572 -1.382
ENSG00000114423 E050 0.0000000       3 105869337 105869422 86 -      
ENSG00000114423 E051 0.0000000       3 105869425 105869552 128 -