ENSG00000114354

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000240851 ENSG00000114354 HEK293_OSMI2_2hA HEK293_TMG_2hB TFG protein_coding protein_coding 102.4356 110.664 111.3465 3.477891 1.018543 0.008869545 47.62205 43.916249 62.9898496 6.6055272 1.6221543 0.5202651 0.4681958 0.4005000 0.5656000 0.1651000 1.813183e-01 3.025326e-14 FALSE TRUE
ENST00000476228 ENSG00000114354 HEK293_OSMI2_2hA HEK293_TMG_2hB TFG protein_coding protein_coding 102.4356 110.664 111.3465 3.477891 1.018543 0.008869545 17.09476 24.011856 0.5910056 2.1140724 0.5910056 -5.3208254 0.1709125 0.2164333 0.0054000 -0.2110333 5.333805e-03 3.025326e-14 FALSE TRUE
ENST00000490574 ENSG00000114354 HEK293_OSMI2_2hA HEK293_TMG_2hB TFG protein_coding protein_coding 102.4356 110.664 111.3465 3.477891 1.018543 0.008869545 20.67699 29.361196 16.5890659 7.4187350 0.9224537 -0.8232999 0.1978625 0.2621667 0.1489000 -0.1132667 2.285847e-01 3.025326e-14 FALSE TRUE
ENST00000674645 ENSG00000114354 HEK293_OSMI2_2hA HEK293_TMG_2hB TFG protein_coding protein_coding 102.4356 110.664 111.3465 3.477891 1.018543 0.008869545 10.44488 8.359179 21.0236075 0.5550917 0.4116769 1.3295383 0.0997875 0.0760000 0.1888333 0.1128333 1.318051e-10 3.025326e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114354 E001 0.5085815 0.2755356459 6.365295e-01 7.505312e-01 3 100709295 100709316 22 + 0.120 0.222 1.065
ENSG00000114354 E002 7.3875613 0.0023400226 9.630624e-01 9.806623e-01 3 100709317 100709352 36 + 0.921 0.936 0.053
ENSG00000114354 E003 10.5891863 0.0185960476 3.038279e-01 4.458125e-01 3 100709353 100709361 9 + 1.119 1.023 -0.349
ENSG00000114354 E004 41.0562244 0.0005155905 8.831714e-03 2.586000e-02 3 100709362 100709413 52 + 1.684 1.562 -0.414
ENSG00000114354 E005 42.3806449 0.0005200282 8.265982e-03 2.445675e-02 3 100709414 100709428 15 + 1.695 1.574 -0.412
ENSG00000114354 E006 38.8691092 0.0005493022 1.774296e-02 4.658255e-02 3 100709429 100709431 3 + 1.654 1.542 -0.382
ENSG00000114354 E007 8.3587173 0.0020414141 3.888212e-01 5.329121e-01 3 100709432 100709439 8 + 1.011 0.936 -0.281
ENSG00000114354 E008 11.7112620 0.0018423544 2.786108e-01 4.182683e-01 3 100709440 100709456 17 + 1.149 1.065 -0.304
ENSG00000114354 E009 12.7304100 0.0141307383 7.272492e-01 8.200562e-01 3 100709457 100709461 5 + 1.108 1.164 0.201
ENSG00000114354 E010 12.7638212 0.0218383668 7.417245e-01 8.307712e-01 3 100709462 100709462 1 + 1.108 1.164 0.202
ENSG00000114354 E011 16.8651541 0.0150733165 1.399085e-01 2.478980e-01 3 100709463 100709471 9 + 1.159 1.330 0.603
ENSG00000114354 E012 40.9149159 0.0005236883 1.253270e-02 3.481098e-02 3 100709472 100709493 22 + 1.681 1.566 -0.391
ENSG00000114354 E013 108.9181663 0.0002920041 1.961958e-13 5.348786e-12 3 100709494 100709535 42 + 2.148 1.915 -0.781
ENSG00000114354 E014 115.7599214 0.0034019671 3.296486e-11 6.304355e-10 3 100709536 100709549 14 + 2.189 1.917 -0.911
ENSG00000114354 E015 170.7981760 0.0126775865 9.181143e-07 7.681856e-06 3 100709550 100709588 39 + 2.362 2.079 -0.946
ENSG00000114354 E016 180.3611259 0.0259892151 3.910697e-03 1.289299e-02 3 100709589 100709605 17 + 2.358 2.144 -0.715
ENSG00000114354 E017 168.1837243 0.0225925264 2.411274e-03 8.495446e-03 3 100709606 100709612 7 + 2.328 2.114 -0.714
ENSG00000114354 E018 340.7612202 0.0117098160 5.535248e-05 3.084405e-04 3 100709613 100709721 109 + 2.630 2.425 -0.682
ENSG00000114354 E019 2.1360488 0.0534787644 4.728595e-02 1.043457e-01 3 100709722 100709821 100 + 0.654 0.300 -1.822
ENSG00000114354 E020 4.8381728 0.0032435706 2.652307e-01 4.032677e-01 3 100709970 100710244 275 + 0.829 0.697 -0.531
ENSG00000114354 E021 2.0808783 0.1439536006 5.814683e-01 7.059970e-01 3 100710245 100710295 51 + 0.552 0.424 -0.633
ENSG00000114354 E022 3.3818032 0.0052496906 5.031159e-01 6.391041e-01 3 100710971 100711018 48 + 0.684 0.600 -0.361
ENSG00000114354 E023 3.7494784 0.0054101493 8.181003e-01 8.850210e-01 3 100711019 100711068 50 + 0.684 0.667 -0.071
ENSG00000114354 E024 221.3787282 0.0054320497 2.039087e-07 1.950808e-06 3 100713643 100713653 11 + 2.443 2.237 -0.687
ENSG00000114354 E025 905.6774989 0.0006064529 1.486526e-11 3.010991e-10 3 100713654 100713869 216 + 3.001 2.914 -0.290
ENSG00000114354 E026 767.8517537 0.0009716739 2.748641e-04 1.277469e-03 3 100719975 100720058 84 + 2.911 2.862 -0.164
ENSG00000114354 E027 1015.4545952 0.0006442632 7.556557e-03 2.266266e-02 3 100728712 100728858 147 + 3.018 2.997 -0.071
ENSG00000114354 E028 3.8469350 0.0040460998 7.908639e-03 2.354804e-02 3 100728859 100729830 972 + 0.849 0.475 -1.610
ENSG00000114354 E029 0.9243042 0.0144253059 9.845634e-01 9.944106e-01 3 100731742 100731895 154 + 0.292 0.300 0.052
ENSG00000114354 E030 952.6596451 0.0003968221 6.519470e-02 1.353572e-01 3 100732508 100732672 165 + 2.954 3.001 0.157
ENSG00000114354 E031 31.9469875 0.0006261665 1.344052e-34 3.198827e-32 3 100732673 100736575 3903 + 1.792 0.919 -3.064
ENSG00000114354 E032 792.6723393 0.0003473484 6.541614e-05 3.579795e-04 3 100736576 100736704 129 + 2.855 2.936 0.269
ENSG00000114354 E033 291.9633948 0.0001730499 3.163839e-06 2.354757e-05 3 100736705 100736716 12 + 2.399 2.520 0.403
ENSG00000114354 E034 5.4077846 0.0029937766 2.491228e-10 4.102535e-09 3 100739361 100739485 125 + 1.086 0.124 -5.075
ENSG00000114354 E035 4.0393528 0.0040497794 1.831047e-06 1.436442e-05 3 100742156 100742200 45 + 0.954 0.221 -3.590
ENSG00000114354 E036 46.0232363 0.0036735741 6.928148e-39 2.220841e-36 3 100742476 100744832 2357 + 1.944 1.053 -3.079
ENSG00000114354 E037 373.5707322 0.0001823301 2.445297e-06 1.866455e-05 3 100744833 100744837 5 + 2.511 2.622 0.371
ENSG00000114354 E038 655.5958493 0.0005459677 1.093393e-11 2.263332e-10 3 100744838 100744931 94 + 2.737 2.876 0.463
ENSG00000114354 E039 33.5428591 0.0007398044 9.296799e-42 3.623972e-39 3 100744932 100747245 2314 + 1.825 0.822 -3.545
ENSG00000114354 E040 2.8795540 0.0295969655 1.502162e-02 4.053615e-02 3 100747246 100747308 63 + 0.763 0.366 -1.857
ENSG00000114354 E041 2.4377949 0.0405028348 3.514411e-03 1.176752e-02 3 100747309 100747360 52 + 0.738 0.221 -2.752
ENSG00000114354 E042 3.0602142 0.0296088887 1.035909e-02 2.964769e-02 3 100747361 100747413 53 + 0.786 0.366 -1.947
ENSG00000114354 E043 3.2064430 0.0056014773 1.219010e-01 2.226206e-01 3 100747414 100747454 41 + 0.738 0.521 -0.948
ENSG00000114354 E044 321.9254610 0.0022469450 1.527719e-03 5.726817e-03 3 100748149 100748152 4 + 2.443 2.558 0.384
ENSG00000114354 E045 2800.4713503 0.0028854564 2.431816e-12 5.601901e-11 3 100748153 100748964 812 + 3.349 3.516 0.555