ENSG00000114346

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000232458 ENSG00000114346 HEK293_OSMI2_2hA HEK293_TMG_2hB ECT2 protein_coding protein_coding 23.36209 5.797173 40.96057 0.4786194 2.105646 2.81868 13.5508998 1.00432638 24.9434670 0.26956077 1.86686432 4.6206464 0.42756250 0.1744000 0.608466667 0.43406667 7.411471e-07 7.329414e-22 FALSE TRUE
ENST00000392692 ENSG00000114346 HEK293_OSMI2_2hA HEK293_TMG_2hB ECT2 protein_coding protein_coding 23.36209 5.797173 40.96057 0.4786194 2.105646 2.81868 4.8121200 0.47742406 9.4897681 0.12325396 1.14567225 4.2846429 0.17868333 0.0868000 0.231933333 0.14513333 3.730287e-02 7.329414e-22 FALSE TRUE
ENST00000437296 ENSG00000114346 HEK293_OSMI2_2hA HEK293_TMG_2hB ECT2 protein_coding protein_coding 23.36209 5.797173 40.96057 0.4786194 2.105646 2.81868 0.4710367 1.57838573 0.3280390 0.39048095 0.32803901 -2.2322996 0.07132083 0.2651667 0.007333333 -0.25783333 4.343026e-03 7.329414e-22 FALSE TRUE
ENST00000441497 ENSG00000114346 HEK293_OSMI2_2hA HEK293_TMG_2hB ECT2 protein_coding protein_coding 23.36209 5.797173 40.96057 0.4786194 2.105646 2.81868 0.7369011 1.77999478 0.0000000 0.26809172 0.00000000 -7.4838116 0.13571250 0.3174000 0.000000000 -0.31740000 7.329414e-22 7.329414e-22 FALSE TRUE
ENST00000487073 ENSG00000114346 HEK293_OSMI2_2hA HEK293_TMG_2hB ECT2 protein_coding retained_intron 23.36209 5.797173 40.96057 0.4786194 2.105646 2.81868 0.5499630 0.62729133 0.4775167 0.56032473 0.08009099 -0.3865014 0.05648333 0.0957000 0.011666667 -0.08403333 7.204254e-01 7.329414e-22   FALSE
ENST00000540509 ENSG00000114346 HEK293_OSMI2_2hA HEK293_TMG_2hB ECT2 protein_coding protein_coding 23.36209 5.797173 40.96057 0.4786194 2.105646 2.81868 1.4311319 0.05887597 2.1245817 0.05887597 1.12991161 4.9538088 0.05634583 0.0116000 0.053900000 0.04230000 6.797238e-01 7.329414e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114346 E001 0.2944980 0.3957823717 1.000000e+00   3 172750682 172750684 3 + 0.077 0.000 -9.606
ENSG00000114346 E002 1.0351233 0.0120895355 5.368235e-01 6.685310e-01 3 172750685 172750704 20 + 0.226 0.000 -11.220
ENSG00000114346 E003 4.7253367 0.0100332683 1.863918e-02 4.854263e-02 3 172750705 172750725 21 + 0.615 0.000 -13.413
ENSG00000114346 E004 23.5176780 0.0008993012 4.392410e-05 2.509107e-04 3 172750726 172750757 32 + 1.208 0.629 -2.216
ENSG00000114346 E005 23.8143661 0.0008529867 3.649252e-05 2.123410e-04 3 172750758 172750762 5 + 1.213 0.629 -2.235
ENSG00000114346 E006 74.9277549 0.0003280821 3.172272e-06 2.360477e-05 3 172750763 172750857 95 + 1.678 1.396 -0.966
ENSG00000114346 E007 0.0000000       3 172750959 172750979 21 +      
ENSG00000114346 E008 0.0000000       3 172750980 172750994 15 +      
ENSG00000114346 E009 0.0000000       3 172750995 172751016 22 +      
ENSG00000114346 E010 0.5954526 0.0183446120 1.000000e+00 1.000000e+00 3 172751017 172751116 100 + 0.143 0.000 -10.413
ENSG00000114346 E011 14.7697208 0.0012563364 3.370408e-01 4.808995e-01 3 172752150 172752272 123 + 0.991 0.934 -0.209
ENSG00000114346 E012 16.3814073 0.0013405526 5.513397e-01 6.808196e-01 3 172752273 172752436 164 + 1.028 1.032 0.016
ENSG00000114346 E013 6.4499160 0.0027970486 1.968923e-01 3.223453e-01 3 172752437 172752472 36 + 0.699 0.501 -0.882
ENSG00000114346 E014 0.2924217 0.0273417479 1.000000e+00   3 172754457 172754508 52 + 0.077 0.000 -9.413
ENSG00000114346 E015 137.1102472 0.0002536752 3.776743e-12 8.429461e-11 3 172754509 172754660 152 + 1.939 1.603 -1.138
ENSG00000114346 E016 62.5908998 0.0003769230 4.859577e-08 5.254151e-07 3 172755295 172755297 3 + 1.610 1.179 -1.494
ENSG00000114346 E017 112.8467421 0.0002496201 4.851927e-08 5.247377e-07 3 172755298 172755374 77 + 1.852 1.591 -0.886
ENSG00000114346 E018 30.9076206 0.0009980485 9.400683e-04 3.754387e-03 3 172755483 172755575 93 + 1.310 0.986 -1.162
ENSG00000114346 E019 171.3260607 0.0002734579 2.110048e-09 2.941877e-08 3 172756983 172757165 183 + 2.029 1.813 -0.725
ENSG00000114346 E020 126.1416410 0.0002443602 6.070339e-06 4.239815e-05 3 172758980 172759069 90 + 1.895 1.725 -0.573
ENSG00000114346 E021 139.3400008 0.0002116075 5.069387e-07 4.480221e-06 3 172760156 172760263 108 + 1.938 1.751 -0.633
ENSG00000114346 E022 105.3492574 0.0002818574 3.238446e-03 1.096834e-02 3 172761610 172761683 74 + 1.810 1.725 -0.289
ENSG00000114346 E023 116.7947036 0.0098818608 3.230422e-01 4.663840e-01 3 172762416 172762546 131 + 1.843 1.867 0.080
ENSG00000114346 E024 112.1594107 0.0002822721 9.189282e-02 1.780607e-01 3 172762691 172762786 96 + 1.829 1.827 -0.006
ENSG00000114346 E025 72.7686416 0.0003566027 4.828719e-02 1.061385e-01 3 172762787 172762806 20 + 1.651 1.603 -0.163
ENSG00000114346 E026 105.7518581 0.0003349724 1.089467e-02 3.091198e-02 3 172762910 172762972 63 + 1.810 1.751 -0.199
ENSG00000114346 E027 169.4788825 0.0002521167 4.053498e-04 1.795304e-03 3 172764278 172764413 136 + 2.013 1.938 -0.252
ENSG00000114346 E028 146.1198606 0.0002108730 1.750335e-02 4.605099e-02 3 172764414 172764500 87 + 1.946 1.922 -0.083
ENSG00000114346 E029 158.8294592 0.0002187054 8.037362e-03 2.387428e-02 3 172769007 172769143 137 + 1.983 1.949 -0.113
ENSG00000114346 E030 140.8618676 0.0002471466 3.560961e-02 8.282665e-02 3 172773903 172774022 120 + 1.929 1.916 -0.043
ENSG00000114346 E031 116.1406445 0.0002629696 1.679144e-02 4.447829e-02 3 172782163 172782231 69 + 1.848 1.806 -0.141
ENSG00000114346 E032 157.4377299 0.0002180981 4.104005e-03 1.343584e-02 3 172783799 172783909 111 + 1.979 1.933 -0.154
ENSG00000114346 E033 165.4563093 0.0002416282 3.133535e-02 7.455152e-02 3 172784707 172784803 97 + 1.996 1.989 -0.022
ENSG00000114346 E034 145.5871939 0.0003883340 6.803477e-02 1.401068e-01 3 172786493 172786574 82 + 1.941 1.944 0.009
ENSG00000114346 E035 140.7670806 0.0002752259 5.719570e-01 6.981581e-01 3 172802616 172802690 75 + 1.919 1.985 0.219
ENSG00000114346 E036 81.0759452 0.0003363466 8.243700e-01 8.893558e-01 3 172802691 172802694 4 + 1.682 1.759 0.263
ENSG00000114346 E037 164.6493246 0.0002282942 5.239917e-01 6.576174e-01 3 172802861 172802980 120 + 1.980 2.100 0.400
ENSG00000114346 E038 197.1801904 0.0002494610 1.779163e-01 2.985203e-01 3 172805731 172805869 139 + 2.055 2.200 0.483
ENSG00000114346 E039 0.7533107 0.2897701020 1.000000e+00 1.000000e+00 3 172805870 172806107 238 + 0.173 0.000 -10.745
ENSG00000114346 E040 1.0287806 0.0122390818 5.373084e-01 6.689105e-01 3 172807706 172807769 64 + 0.226 0.000 -11.220
ENSG00000114346 E041 219.2645620 0.0002330173 1.398679e-01 2.478491e-01 3 172807770 172807924 155 + 2.101 2.247 0.489
ENSG00000114346 E042 166.3941495 0.0002713041 2.347334e-03 8.299153e-03 3 172815604 172815711 108 + 1.973 2.188 0.720
ENSG00000114346 E043 197.2522282 0.0002554405 2.990850e-07 2.768824e-06 3 172816691 172816837 147 + 2.036 2.312 0.921
ENSG00000114346 E044 4.3380035 0.0321518775 5.731569e-01 6.991453e-01 3 172818331 172818547 217 + 0.561 0.501 -0.283
ENSG00000114346 E045 15.4459032 0.0050043437 6.856844e-01 7.883591e-01 3 172818548 172818814 267 + 1.003 1.032 0.106
ENSG00000114346 E046 668.9368189 0.0345109660 1.989499e-06 1.548499e-05 3 172820148 172821474 1327 + 2.527 2.990 1.543