ENSG00000114331

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326793 ENSG00000114331 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAP2 protein_coding protein_coding 4.724516 0.8718465 8.935227 0.102479 0.1697518 3.342519 3.5552041 0.8434431 6.881767 0.08580118 0.4540523 3.013507 0.80547083 0.9712333 0.7706333 -0.2006 0.01835925 0.01032749 FALSE TRUE
MSTRG.24302.2 ENSG00000114331 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAP2 protein_coding   4.724516 0.8718465 8.935227 0.102479 0.1697518 3.342519 0.3232456 0.0000000 1.241890 0.00000000 0.7154521 6.967963 0.04105833 0.0000000 0.1385000 0.1385 0.53413773 0.01032749 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114331 E001 222.5314445 0.0094782762 5.140350e-20 3.270060e-18 3 195274745 195276751 2007 - 2.036 2.534 1.662
ENSG00000114331 E002 34.1652717 0.0009446705 2.327340e-01 3.656951e-01 3 195276752 195276908 157 - 1.295 1.479 0.639
ENSG00000114331 E003 148.1692675 0.0003115066 5.040276e-01 6.399346e-01 3 195276909 195278670 1762 - 1.926 2.036 0.368
ENSG00000114331 E004 28.9979591 0.0130430224 7.091685e-01 8.066249e-01 3 195278671 195278858 188 - 1.247 1.277 0.106
ENSG00000114331 E005 35.3983217 0.0006133954 2.347164e-01 3.680285e-01 3 195278859 195279033 175 - 1.313 1.495 0.629
ENSG00000114331 E006 59.9680975 0.0131901532 3.432958e-01 4.873353e-01 3 195279034 195279428 395 - 1.534 1.694 0.544
ENSG00000114331 E007 0.7406253 0.0154562937 1.000000e+00 1.000000e+00 3 195279622 195279799 178 - 0.168 0.000 -10.645
ENSG00000114331 E008 2.2239521 0.0065711501 1.864243e-01 3.092629e-01 3 195285328 195285795 468 - 0.383 0.000 -12.130
ENSG00000114331 E009 29.8014975 0.0007546489 9.662190e-01 9.828012e-01 3 195285796 195285857 62 - 1.253 1.326 0.254
ENSG00000114331 E010 37.2615446 0.0007846756 5.313642e-01 6.638312e-01 3 195289121 195289231 111 - 1.351 1.370 0.063
ENSG00000114331 E011 34.6001013 0.0020464101 3.265574e-01 4.699834e-01 3 195291706 195291815 110 - 1.325 1.302 -0.079
ENSG00000114331 E012 27.7833650 0.0007534063 7.813696e-01 8.595497e-01 3 195292265 195292313 49 - 1.230 1.277 0.167
ENSG00000114331 E013 36.3522077 0.0005433033 2.074762e-01 3.354792e-01 3 195292314 195292452 139 - 1.349 1.302 -0.165
ENSG00000114331 E014 25.3741789 0.0007308991 1.075729e-01 2.019544e-01 3 195294719 195294811 93 - 1.207 1.087 -0.432
ENSG00000114331 E015 0.0000000       3 195295196 195295300 105 -      
ENSG00000114331 E016 0.1451727 0.0439429247 5.833109e-01   3 195295446 195295707 262 - 0.039 0.000 -8.166
ENSG00000114331 E017 19.6113926 0.0009398560 1.523696e-02 4.102378e-02 3 195295708 195295759 52 - 1.114 0.820 -1.099
ENSG00000114331 E018 31.3739794 0.0008636549 5.964936e-02 1.260248e-01 3 195295760 195295892 133 - 1.295 1.160 -0.477
ENSG00000114331 E019 20.4209035 0.0009533970 1.095339e-02 3.105070e-02 3 195297190 195297223 34 - 1.130 0.820 -1.155
ENSG00000114331 E020 26.8718757 0.0006878831 6.697886e-02 1.383501e-01 3 195297224 195297281 58 - 1.232 1.087 -0.520
ENSG00000114331 E021 28.8443048 0.0006837952 6.917910e-02 1.420095e-01 3 195301575 195301644 70 - 1.260 1.125 -0.481
ENSG00000114331 E022 37.2905823 0.0015556141 1.789561e-02 4.691376e-02 3 195301966 195302147 182 - 1.369 1.192 -0.621
ENSG00000114331 E023 19.5020816 0.0098927941 5.626802e-02 1.201823e-01 3 195302148 195302174 27 - 1.107 0.888 -0.812
ENSG00000114331 E024 29.2770396 0.0007449533 6.048185e-02 1.274412e-01 3 195306511 195306616 106 - 1.267 1.125 -0.504
ENSG00000114331 E025 0.0000000       3 195306617 195306865 249 -      
ENSG00000114331 E026 26.7263242 0.0008588264 7.096853e-02 1.449497e-01 3 195307223 195307323 101 - 1.230 1.087 -0.511
ENSG00000114331 E027 13.7430457 0.0012841121 1.770908e-01 2.974493e-01 3 195308786 195308837 52 - 0.965 0.820 -0.553
ENSG00000114331 E028 0.0000000       3 195312947 195312967 21 -      
ENSG00000114331 E029 23.2439777 0.0008295271 2.084632e-01 3.366269e-01 3 195320701 195320813 113 - 1.167 1.087 -0.290
ENSG00000114331 E030 0.0000000       3 195325444 195325455 12 -      
ENSG00000114331 E031 0.1472490 0.0444822897 5.839943e-01   3 195326332 195326884 553 - 0.039 0.000 -8.162
ENSG00000114331 E032 29.4932315 0.0006601015 1.688103e-03 6.244990e-03 3 195326885 195326959 75 - 1.280 0.947 -1.202
ENSG00000114331 E033 29.3020639 0.0006483585 1.416709e-04 7.107254e-04 3 195333028 195333081 54 - 1.282 0.820 -1.695
ENSG00000114331 E034 26.5929492 0.0010051198 2.151213e-03 7.693515e-03 3 195333082 195333123 42 - 1.237 0.888 -1.274
ENSG00000114331 E035 0.0000000       3 195335899 195336931 1033 -      
ENSG00000114331 E036 22.1175977 0.0008457315 1.532613e-02 4.122811e-02 3 195336932 195336976 45 - 1.159 0.888 -0.997
ENSG00000114331 E037 36.1041987 0.0030230017 1.382639e-02 3.783244e-02 3 195342471 195342605 135 - 1.358 1.159 -0.700
ENSG00000114331 E038 21.8017691 0.0009289888 5.514124e-03 1.732306e-02 3 195342606 195342654 49 - 1.159 0.820 -1.260
ENSG00000114331 E039 27.2383838 0.0006936020 4.199050e-03 1.370096e-02 3 195345259 195345317 59 - 1.249 0.947 -1.093
ENSG00000114331 E040 0.0000000       3 195356068 195356212 145 -      
ENSG00000114331 E041 0.1472490 0.0444822897 5.839943e-01   3 195357691 195357784 94 - 0.039 0.000 -8.162
ENSG00000114331 E042 22.4868957 0.0008620655 3.216588e-02 7.617733e-02 3 195381009 195381025 17 - 1.165 0.947 -0.795
ENSG00000114331 E043 25.0842714 0.0007990589 2.067078e-01 3.346156e-01 3 195381026 195381062 37 - 1.200 1.125 -0.268
ENSG00000114331 E044 34.7958568 0.0005855101 1.195935e-01 2.193857e-01 3 195381903 195382022 120 - 1.335 1.251 -0.294
ENSG00000114331 E045 21.4732418 0.0021801034 3.439342e-01 4.879856e-01 3 195392090 195392147 58 - 1.133 1.087 -0.166
ENSG00000114331 E046 0.1472490 0.0444822897 5.839943e-01   3 195410707 195411009 303 - 0.039 0.000 -8.162
ENSG00000114331 E047 0.5997190 0.1404905138 1.000000e+00 1.000000e+00 3 195412846 195412916 71 - 0.140 0.000 -9.505
ENSG00000114331 E048 0.2944980 0.4238854727 1.000000e+00   3 195441793 195442120 328 - 0.075 0.000 -7.475
ENSG00000114331 E049 0.0000000       3 195442150 195442276 127 -      
ENSG00000114331 E050 24.2492675 0.1366099071 1.398142e-01 2.477693e-01 3 195442795 195443044 250 - 1.195 0.952 -0.880