ENSG00000114302

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265563 ENSG00000114302 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKAR2A protein_coding protein_coding 37.88098 24.12288 49.72748 4.194378 1.326632 1.043334 29.496318 21.9735610 35.784139 3.9106971 1.2829842 0.7032983 0.8126792 0.91083333 0.71926667 -0.19156667 2.683174e-08 2.683174e-08 FALSE TRUE
ENST00000438535 ENSG00000114302 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKAR2A protein_coding protein_coding 37.88098 24.12288 49.72748 4.194378 1.326632 1.043334 4.855270 1.3544990 7.811786 0.5078641 0.5419951 2.5191268 0.1085708 0.05713333 0.15786667 0.10073333 2.288368e-02 2.683174e-08 FALSE FALSE
ENST00000454963 ENSG00000114302 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKAR2A protein_coding protein_coding 37.88098 24.12288 49.72748 4.194378 1.326632 1.043334 2.103077 0.5821711 4.320147 0.2246138 0.2376855 2.8703302 0.0462625 0.02300000 0.08676667 0.06376667 1.095158e-05 2.683174e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114302 E001 0.6265839 0.0179861852 1.157591e-02 3.252729e-02 3 48744597 48744647 51 - 0.000 0.454 11.164
ENSG00000114302 E002 1.0683430 0.0569304036 1.802112e-02 4.717814e-02 3 48744648 48744767 120 - 0.090 0.572 3.574
ENSG00000114302 E003 1097.2349371 0.0107432174 7.681072e-18 3.825332e-16 3 48746586 48747514 929 - 2.778 3.265 1.620
ENSG00000114302 E004 770.2796293 0.0026448746 2.959483e-16 1.201082e-14 3 48747515 48747940 426 - 2.736 3.043 1.021
ENSG00000114302 E005 1585.4195103 0.0005895932 1.189943e-18 6.511585e-17 3 48747941 48749647 1707 - 3.106 3.305 0.663
ENSG00000114302 E006 1009.9558285 0.0023920496 2.423594e-03 8.533140e-03 3 48749648 48751257 1610 - 2.991 2.996 0.018
ENSG00000114302 E007 177.2403611 0.0020232473 1.111764e-04 5.731476e-04 3 48751258 48751338 81 - 2.258 2.211 -0.156
ENSG00000114302 E008 190.8600701 0.0041104781 2.133005e-04 1.021000e-03 3 48751339 48751420 82 - 2.296 2.226 -0.233
ENSG00000114302 E009 252.4135271 0.0088610015 1.759428e-03 6.470064e-03 3 48751421 48751584 164 - 2.421 2.338 -0.277
ENSG00000114302 E010 269.6224353 0.0032884227 7.157838e-07 6.135053e-06 3 48751585 48751718 134 - 2.453 2.366 -0.289
ENSG00000114302 E011 8.4054784 0.0020792244 1.451373e-03 5.478128e-03 3 48751903 48752112 210 - 1.054 0.749 -1.161
ENSG00000114302 E012 250.0270655 0.0002156988 9.232913e-18 4.561011e-16 3 48752176 48752317 142 - 2.430 2.318 -0.373
ENSG00000114302 E013 0.7771569 0.0154519086 3.928550e-01 5.367461e-01 3 48752318 48752318 1 - 0.283 0.165 -0.990
ENSG00000114302 E014 203.0655251 0.0002228512 3.574712e-16 1.431752e-14 3 48756379 48756444 66 - 2.343 2.220 -0.409
ENSG00000114302 E015 243.6762678 0.0009964915 4.918393e-15 1.693520e-13 3 48765004 48765078 75 - 2.423 2.292 -0.436
ENSG00000114302 E016 281.2317000 0.0064072726 1.256148e-08 1.520986e-07 3 48765248 48765349 102 - 2.497 2.317 -0.602
ENSG00000114302 E017 0.4438354 0.0305546951 3.345492e-01 4.782913e-01 3 48765350 48765350 1 - 0.090 0.283 2.004
ENSG00000114302 E018 291.7614487 0.0014596098 2.106439e-22 1.757968e-20 3 48772955 48773108 154 - 2.519 2.325 -0.645
ENSG00000114302 E019 203.1683763 0.0001939822 3.977368e-25 4.398718e-23 3 48782986 48783086 101 - 2.361 2.176 -0.616
ENSG00000114302 E020 92.1322618 0.0003205068 3.062581e-15 1.087937e-13 3 48783087 48783092 6 - 2.030 1.808 -0.748
ENSG00000114302 E021 134.9632626 0.0014082169 1.752311e-17 8.324226e-16 3 48790544 48790598 55 - 2.195 1.961 -0.782
ENSG00000114302 E022 106.6548371 0.0173036629 2.755865e-04 1.280324e-03 3 48790599 48790627 29 - 2.083 1.881 -0.680
ENSG00000114302 E023 134.3435210 0.0054627680 6.032301e-11 1.102345e-09 3 48793997 48794049 53 - 2.196 1.949 -0.825
ENSG00000114302 E024 106.6845100 0.0061660774 3.173124e-11 6.084402e-10 3 48807649 48807684 36 - 2.106 1.825 -0.944
ENSG00000114302 E025 217.5797140 0.0285183486 2.661957e-06 2.015828e-05 3 48847335 48847874 540 - 2.424 2.089 -1.117