ENSG00000114209

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000473645 ENSG00000114209 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD10 protein_coding protein_coding 28.64904 11.13733 46.32368 1.375573 1.175335 2.055363 4.271314 0.9764319 8.591092 0.2932547 0.6029541 3.124229 0.1377667 0.08416667 0.1857333 0.1015667 0.004436648 0.004436648 FALSE TRUE
ENST00000497056 ENSG00000114209 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD10 protein_coding protein_coding 28.64904 11.13733 46.32368 1.375573 1.175335 2.055363 20.776677 8.9216905 31.639324 1.0569353 1.6116878 1.825170 0.7443708 0.80340000 0.6822000 -0.1212000 0.065638489 0.004436648 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114209 E001 14.7181785 0.0056815467 4.326925e-02 9.705343e-02 3 167683298 167683909 612 - 1.090 1.297 0.735
ENSG00000114209 E002 3.0600347 0.0838081914 8.856204e-03 2.592289e-02 3 167683910 167683911 2 - 0.378 0.908 2.352
ENSG00000114209 E003 85.8900711 0.0062616154 2.768313e-09 3.784447e-08 3 167683912 167684113 202 - 1.776 2.107 1.113
ENSG00000114209 E004 157.1298557 0.0011416187 2.478071e-07 2.332620e-06 3 167684114 167684241 128 - 2.093 2.271 0.594
ENSG00000114209 E005 84.8113526 0.0004886790 2.142329e-02 5.448122e-02 3 167684242 167684255 14 - 1.850 1.954 0.348
ENSG00000114209 E006 142.6558231 0.0009837846 3.570569e-01 5.014743e-01 3 167684256 167684338 83 - 2.093 2.130 0.123
ENSG00000114209 E007 155.2508489 0.0003057114 7.187914e-01 8.137838e-01 3 167684339 167684389 51 - 2.134 2.151 0.057
ENSG00000114209 E008 0.1451727 0.0433239412 1.000000e+00   3 167687215 167687221 7 - 0.070 0.000 -9.164
ENSG00000114209 E009 0.1451727 0.0433239412 1.000000e+00   3 167687222 167687222 1 - 0.070 0.000 -9.164
ENSG00000114209 E010 0.7448917 0.0644864476 2.658643e-01 4.039685e-01 3 167687223 167687233 11 - 0.272 0.000 -11.490
ENSG00000114209 E011 192.8639935 0.0015400452 8.087553e-01 8.785387e-01 3 167687234 167687316 83 - 2.232 2.227 -0.014
ENSG00000114209 E012 138.0042341 0.0024519131 4.317474e-01 5.742749e-01 3 167687615 167687648 34 - 2.093 2.064 -0.097
ENSG00000114209 E013 147.5105013 0.0002141855 2.039009e-01 3.310746e-01 3 167687649 167687686 38 - 2.126 2.089 -0.124
ENSG00000114209 E014 109.8473361 0.0003042534 3.302893e-01 4.738855e-01 3 167687687 167687693 7 - 2.000 1.968 -0.107
ENSG00000114209 E015 123.4754990 0.0002518071 2.865267e-01 4.269370e-01 3 167695596 167695608 13 - 2.050 2.017 -0.112
ENSG00000114209 E016 228.4122936 0.0001937572 5.075749e-01 6.430420e-01 3 167695609 167695722 114 - 2.308 2.296 -0.040
ENSG00000114209 E017 0.1451727 0.0433239412 1.000000e+00   3 167697007 167697008 2 - 0.070 0.000 -9.164
ENSG00000114209 E018 137.3411555 0.0004157690 8.592635e-01 9.131983e-01 3 167697009 167697039 31 - 2.086 2.085 -0.002
ENSG00000114209 E019 190.2896256 0.0007020930 6.542982e-02 1.357635e-01 3 167697040 167697126 87 - 2.239 2.185 -0.180
ENSG00000114209 E020 1.1782197 0.0108647759 9.280359e-02 1.795051e-01 3 167697851 167697978 128 - 0.378 0.000 -12.110
ENSG00000114209 E021 0.2924217 0.0271941665 1.000000e+00   3 167704558 167704841 284 - 0.130 0.000 -10.145
ENSG00000114209 E022 161.8519352 0.0019646468 3.476497e-01 4.918391e-01 3 167704842 167704895 54 - 2.164 2.131 -0.112
ENSG00000114209 E023 216.2625025 0.0003429601 5.366787e-02 1.156706e-01 3 167720062 167720204 143 - 2.294 2.243 -0.168
ENSG00000114209 E024 146.7975887 0.0002410747 2.381838e-02 5.944147e-02 3 167720205 167720273 69 - 2.131 2.058 -0.243
ENSG00000114209 E025 27.2293299 0.0007314880 4.663854e-06 3.342993e-05 3 167725401 167725473 73 - 1.470 1.055 -1.460
ENSG00000114209 E026 0.1451727 0.0433239412 1.000000e+00   3 167725474 167725477 4 - 0.070 0.000 -9.164
ENSG00000114209 E027 0.0000000       3 167730703 167730976 274 -      
ENSG00000114209 E028 10.0840352 0.0086941257 3.162935e-01 4.590440e-01 3 167734214 167734246 33 - 1.016 0.887 -0.482
ENSG00000114209 E029 11.4976652 0.0023456716 8.802853e-01 9.272171e-01 3 167734247 167734345 99 - 1.044 1.032 -0.047
ENSG00000114209 E030 3.8749219 0.0811259525 8.834676e-01 9.294528e-01 3 167734346 167734350 5 - 0.651 0.608 -0.185
ENSG00000114209 E031 0.9651910 0.0130908249 5.446860e-01 6.751094e-01 3 167734351 167734431 81 - 0.229 0.346 0.811
ENSG00000114209 E032 0.4847352 0.2565613687 6.263967e-01 7.423558e-01 3 167734432 167734458 27 - 0.130 0.207 0.810
ENSG00000114209 E033 2.9527180 0.0052314586 3.667282e-01 5.110757e-01 3 167734459 167734661 203 - 0.513 0.668 0.694
ENSG00000114209 E034 2.5034703 0.0509833525 4.626839e-01 6.025412e-01 3 167734662 167734805 144 - 0.464 0.607 0.672
ENSG00000114209 E035 101.2246031 0.0003402340 2.268751e-02 5.710672e-02 3 167734806 167734939 134 - 1.975 1.884 -0.304