ENSG00000114200

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264381 ENSG00000114200 HEK293_OSMI2_2hA HEK293_TMG_2hB BCHE protein_coding protein_coding 0.5167314 0.573684 0.3829363 0.1704656 0.02800766 -0.5708921 0.37211102 0.27525155 0.3829363 0.04835287 0.02800766 0.4620607 0.75817917 0.5855667 1 0.4144333 0.02668067 0.02668067 FALSE TRUE
ENST00000479451 ENSG00000114200 HEK293_OSMI2_2hA HEK293_TMG_2hB BCHE protein_coding protein_coding 0.5167314 0.573684 0.3829363 0.1704656 0.02800766 -0.5708921 0.11306640 0.23757982 0.0000000 0.23757982 0.00000000 -4.6298218 0.18303750 0.2605667 0 -0.2605667 0.80746964 0.02668067 FALSE FALSE
ENST00000497011 ENSG00000114200 HEK293_OSMI2_2hA HEK293_TMG_2hB BCHE protein_coding nonsense_mediated_decay 0.5167314 0.573684 0.3829363 0.1704656 0.02800766 -0.5708921 0.01095306 0.06085262 0.0000000 0.03148455 0.00000000 -2.8248212 0.02507917 0.1538667 0 -0.1538667 0.32971528 0.02668067 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114200 E001 0.0000000       3 165772904 165772904 1 -      
ENSG00000114200 E002 1.1061078 0.015526571 0.159229743 0.274088028 3 165772905 165773078 174 - 0.137 0.387 1.955
ENSG00000114200 E003 7.2735890 0.007243862 0.004576052 0.014753059 3 165773079 165773506 428 - 0.672 1.008 1.312
ENSG00000114200 E004 0.4481018 0.026483346 0.735691384 0.826383441 3 165777717 165777795 79 - 0.137 0.196 0.629
ENSG00000114200 E005 0.0000000       3 165778274 165778738 465 -      
ENSG00000114200 E006 6.4043838 0.003206036 0.293675206 0.434726688 3 165786145 165786311 167 - 0.790 0.912 0.469
ENSG00000114200 E007 0.2955422 0.031442224 0.846077522   3 165827986 165828069 84 - 0.137 0.109 -0.369
ENSG00000114200 E008 17.2888640 0.001784768 0.001676813 0.006208682 3 165829517 165831041 1525 - 1.358 1.185 -0.607
ENSG00000114200 E009 1.8779411 0.017532579 0.472359559 0.611401036 3 165837314 165837420 107 - 0.507 0.387 -0.625
ENSG00000114200 E010 0.3268771 0.030492560 0.854885169   3 165837421 165837423 3 - 0.137 0.109 -0.365
ENSG00000114200 E011 0.3268771 0.030492560 0.854885169   3 165837424 165837462 39 - 0.137 0.109 -0.365