ENSG00000114127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392981 ENSG00000114127 HEK293_OSMI2_2hA HEK293_TMG_2hB XRN1 protein_coding protein_coding 4.411724 0.57801 6.832683 0.05995497 0.1589726 3.54065 2.43263856 0.48895485 3.5938719 0.05055507 0.1424922 2.852567 0.69449167 0.85803333 0.5262000 -0.33183333 0.008565785 0.008565785 FALSE TRUE
ENST00000472625 ENSG00000114127 HEK293_OSMI2_2hA HEK293_TMG_2hB XRN1 protein_coding retained_intron 4.411724 0.57801 6.832683 0.05995497 0.1589726 3.54065 0.66403770 0.00000000 1.1123467 0.00000000 0.2671778 6.810375 0.07885417 0.00000000 0.1625333 0.16253333 0.010853999 0.008565785 FALSE FALSE
ENST00000486211 ENSG00000114127 HEK293_OSMI2_2hA HEK293_TMG_2hB XRN1 protein_coding nonsense_mediated_decay 4.411724 0.57801 6.832683 0.05995497 0.1589726 3.54065 0.05865761 0.03978368 0.0000000 0.03978368 0.0000000 -2.315673 0.01480000 0.06096667 0.0000000 -0.06096667 0.210270129 0.008565785 FALSE TRUE
MSTRG.23842.5 ENSG00000114127 HEK293_OSMI2_2hA HEK293_TMG_2hB XRN1 protein_coding   4.411724 0.57801 6.832683 0.05995497 0.1589726 3.54065 0.50370853 0.00000000 0.7521284 0.00000000 0.3761556 6.251962 0.06444167 0.00000000 0.1077333 0.10773333 0.600769258 0.008565785 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114127 E001 0.3729606 0.0298664882 9.924328e-02 1.893273e-01 3 142306607 142306609 3 - 0.038 0.337 3.700
ENSG00000114127 E002 182.4063990 0.0212177090 2.821636e-14 8.679177e-13 3 142306610 142309391 2782 - 1.916 2.513 1.999
ENSG00000114127 E003 86.6412205 0.0003520745 9.199093e-01 9.534113e-01 3 142309392 142311014 1623 - 1.684 1.792 0.364
ENSG00000114127 E004 27.0252970 0.0007130407 1.615431e-01 2.771134e-01 3 142311015 142311519 505 - 1.182 1.428 0.861
ENSG00000114127 E005 30.8853484 0.0008539766 2.101218e-01 3.386873e-01 3 142311520 142311813 294 - 1.237 1.464 0.790
ENSG00000114127 E006 25.9900645 0.0007961450 1.799139e-01 3.010755e-01 3 142312598 142312758 161 - 1.194 1.143 -0.183
ENSG00000114127 E007 1.0371996 0.0229472282 6.291814e-01 7.446013e-01 3 142313136 142313174 39 - 0.213 0.000 -10.950
ENSG00000114127 E008 14.0509832 0.0035902184 7.243254e-02 1.473866e-01 3 142318592 142318646 55 - 0.961 0.755 -0.794
ENSG00000114127 E009 14.0511221 0.0193857844 3.881580e-01 5.322710e-01 3 142318647 142318694 48 - 0.952 0.905 -0.177
ENSG00000114127 E010 15.5909272 0.0011396917 2.033398e-01 3.303798e-01 3 142318790 142318903 114 - 0.994 0.905 -0.333
ENSG00000114127 E011 13.9182936 0.0012487097 3.442280e-01 4.882927e-01 3 142329434 142329483 50 - 0.948 0.905 -0.161
ENSG00000114127 E012 22.3540297 0.0008418674 3.671377e-02 8.492653e-02 3 142329484 142329615 132 - 1.144 0.964 -0.656
ENSG00000114127 E013 16.4854567 0.0021785638 1.435209e-01 2.528066e-01 3 142332375 142332424 50 - 1.021 0.905 -0.433
ENSG00000114127 E014 18.2751504 0.0010096138 2.947267e-02 7.091610e-02 3 142332425 142332531 107 - 1.067 0.836 -0.864
ENSG00000114127 E015 7.7234509 0.0021459287 1.386755e-01 2.462683e-01 3 142332532 142332534 3 - 0.742 0.524 -0.947
ENSG00000114127 E016 0.7394793 0.0153787590 4.356583e-01 5.778610e-01 3 142332865 142332966 102 - 0.134 0.337 1.696
ENSG00000114127 E017 18.9770790 0.0010583393 5.530121e-02 1.185119e-01 3 142332967 142333089 123 - 1.080 0.905 -0.649
ENSG00000114127 E018 12.0636019 0.0326853087 9.153158e-01 9.504079e-01 3 142335448 142335509 62 - 0.885 0.962 0.292
ENSG00000114127 E019 18.5878800 0.0034527636 4.404893e-01 5.821656e-01 3 142347234 142347342 109 - 1.060 1.062 0.008
ENSG00000114127 E020 0.0000000       3 142355324 142355400 77 -      
ENSG00000114127 E021 18.4462963 0.0061458798 7.704991e-02 1.547640e-01 3 142355401 142355496 96 - 1.067 0.904 -0.602
ENSG00000114127 E022 15.7014065 0.0011502278 1.866677e-03 6.811047e-03 3 142356912 142356982 71 - 1.017 0.524 -2.004
ENSG00000114127 E023 18.5099746 0.0050881910 4.730496e-04 2.057012e-03 3 142356983 142357119 137 - 1.083 0.524 -2.246
ENSG00000114127 E024 12.2717995 0.0055575628 1.424251e-01 2.513437e-01 3 142359862 142359931 70 - 0.910 0.755 -0.608
ENSG00000114127 E025 19.1884196 0.0018417431 3.745589e-01 5.189873e-01 3 142365047 142365179 133 - 1.073 1.062 -0.041
ENSG00000114127 E026 15.6172154 0.0011527539 3.719083e-01 5.163823e-01 3 142365310 142365366 57 - 0.990 0.964 -0.096
ENSG00000114127 E027 21.8750454 0.0012866309 9.971373e-02 1.900392e-01 3 142370485 142370620 136 - 1.129 1.016 -0.411
ENSG00000114127 E028 19.4405088 0.0019649279 5.382822e-02 1.159568e-01 3 142371239 142371328 90 - 1.083 0.905 -0.660
ENSG00000114127 E029 22.8890898 0.0008586051 1.205876e-02 3.367475e-02 3 142375798 142375944 147 - 1.155 0.905 -0.918
ENSG00000114127 E030 1.6316055 0.0651613479 3.115487e-01 4.540117e-01 3 142375945 142375991 47 - 0.236 0.527 1.709
ENSG00000114127 E031 0.8856842 0.0773212569 8.216286e-01 8.874849e-01 3 142376249 142376478 230 - 0.188 0.000 -10.719
ENSG00000114127 E032 19.8764532 0.0009308542 4.118031e-02 9.321662e-02 3 142376479 142376594 116 - 1.096 0.905 -0.707
ENSG00000114127 E033 19.3061447 0.0010552815 2.209913e-01 3.516185e-01 3 142380082 142380180 99 - 1.077 1.016 -0.222
ENSG00000114127 E034 18.9590946 0.2784237351 2.108397e-01 3.395448e-01 3 142383300 142383413 114 - 1.076 0.909 -0.618
ENSG00000114127 E035 21.7813897 0.0009036766 3.278989e-01 4.713713e-01 3 142384523 142384685 163 - 1.121 1.104 -0.058
ENSG00000114127 E036 17.6536721 0.0010042411 1.979479e-01 3.236589e-01 3 142397329 142397460 132 - 1.043 0.964 -0.290
ENSG00000114127 E037 16.0137598 0.0020365818 1.776104e-01 2.981318e-01 3 142400444 142400547 104 - 1.005 0.905 -0.376
ENSG00000114127 E038 15.0527335 0.0028702087 2.408720e-01 3.751992e-01 3 142403674 142403772 99 - 0.982 0.905 -0.288
ENSG00000114127 E039 18.9984201 0.0034884742 6.428596e-01 7.555544e-01 3 142403869 142403989 121 - 1.060 1.105 0.161
ENSG00000114127 E040 20.0452853 0.0049614457 3.389532e-01 4.828578e-01 3 142404907 142405073 167 - 1.087 1.063 -0.087
ENSG00000114127 E041 7.7651649 0.0021381069 8.711017e-01 9.211340e-01 3 142405074 142405076 3 - 0.712 0.836 0.496
ENSG00000114127 E042 7.7651649 0.0021381069 8.711017e-01 9.211340e-01 3 142412544 142412547 4 - 0.712 0.836 0.496
ENSG00000114127 E043 17.9100783 0.0010619483 5.383163e-01 6.697565e-01 3 142412548 142412663 116 - 1.039 1.062 0.085
ENSG00000114127 E044 19.3747531 0.0027528593 9.294601e-01 9.595988e-01 3 142414135 142414291 157 - 1.060 1.178 0.424
ENSG00000114127 E045 0.0000000       3 142414292 142414340 49 -      
ENSG00000114127 E046 14.5560413 0.0015799317 5.160060e-01 6.506102e-01 3 142417140 142417229 90 - 0.956 0.964 0.029
ENSG00000114127 E047 5.2006206 0.0031302167 4.537592e-01 5.944822e-01 3 142417841 142418418 578 - 0.600 0.524 -0.348
ENSG00000114127 E048 1.6575426 0.0079936772 3.552083e-01 4.995780e-01 3 142418419 142418503 85 - 0.258 0.524 1.526
ENSG00000114127 E049 22.2327262 0.0102388030 7.236926e-01 8.174519e-01 3 142418504 142418609 106 - 1.118 1.179 0.220
ENSG00000114127 E050 19.4230173 0.0060044282 1.269411e-01 2.298909e-01 3 142418815 142418881 67 - 1.080 0.964 -0.426
ENSG00000114127 E051 25.3095040 0.0042509806 2.454085e-01 3.805155e-01 3 142421016 142421153 138 - 1.179 1.143 -0.127
ENSG00000114127 E052 16.4529019 0.0192652064 2.025701e-01 3.294272e-01 3 142421476 142421543 68 - 1.014 0.906 -0.401
ENSG00000114127 E053 12.8792456 0.0090388524 1.189341e-02 3.327726e-02 3 142422582 142422634 53 - 0.934 0.525 -1.694
ENSG00000114127 E054 13.6232188 0.0013167021 2.759610e-02 6.720590e-02 3 142422635 142422750 116 - 0.952 0.655 -1.178
ENSG00000114127 E055 13.1782495 0.0013349272 1.002085e-01 1.908017e-01 3 142422835 142422922 88 - 0.934 0.755 -0.695
ENSG00000114127 E056 16.4077988 0.0011439097 2.999900e-01 4.416141e-01 3 142423560 142423642 83 - 1.009 0.964 -0.168
ENSG00000114127 E057 16.4999935 0.0012257059 1.493322e-01 2.607542e-01 3 142425222 142425332 111 - 1.017 0.905 -0.419
ENSG00000114127 E058 16.1227651 0.0011181053 1.745419e-01 2.941016e-01 3 142425429 142425538 110 - 1.005 0.905 -0.376
ENSG00000114127 E059 0.1451727 0.0431574670 5.800168e-01   3 142426564 142426743 180 - 0.038 0.000 -8.369
ENSG00000114127 E060 17.2138756 0.0010665075 4.870202e-02 1.068581e-01 3 142426744 142426841 98 - 1.039 0.836 -0.762
ENSG00000114127 E061 0.0000000       3 142429695 142429774 80 -      
ENSG00000114127 E062 24.9564383 0.0007935030 2.469563e-01 3.823653e-01 3 142432661 142432893 233 - 1.174 1.143 -0.110
ENSG00000114127 E063 0.0000000       3 142435013 142435390 378 -      
ENSG00000114127 E064 0.1482932 0.0411897312 2.835541e-02   3 142435951 142436056 106 - 0.000 0.336 12.958
ENSG00000114127 E065 13.2577563 0.0014333246 4.298710e-01 5.725229e-01 3 142447870 142448062 193 - 0.925 0.905 -0.076