ENSG00000114126

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000467072 ENSG00000114126 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP2 protein_coding protein_coding 17.2795 10.83124 24.9558 0.7550352 0.5700402 1.203423 1.0008239 0.5336816 2.5465013 0.2658245 0.1925576 2.233337 0.05230833 0.047666667 0.10186667 0.054200000 1.760147e-01 2.365459e-44 FALSE TRUE
ENST00000474279 ENSG00000114126 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP2 protein_coding protein_coding 17.2795 10.83124 24.9558 0.7550352 0.5700402 1.203423 0.3562400 0.8959392 0.2760997 0.8959392 0.1447399 -1.662896 0.02366667 0.077366667 0.01080000 -0.066566667 8.609185e-01 2.365459e-44 FALSE FALSE
ENST00000479040 ENSG00000114126 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP2 protein_coding protein_coding 17.2795 10.83124 24.9558 0.7550352 0.5700402 1.203423 4.3228336 2.4794264 5.6505281 1.0352429 0.5171812 1.185123 0.21210417 0.223666667 0.22763333 0.003966667 9.342336e-01 2.365459e-44 FALSE TRUE
ENST00000486111 ENSG00000114126 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP2 protein_coding protein_coding 17.2795 10.83124 24.9558 0.7550352 0.5700402 1.203423 2.2965635 0.1039524 3.9030009 0.1039524 0.4776140 5.101773 0.09942083 0.008966667 0.15566667 0.146700000 4.671178e-03 2.365459e-44 FALSE TRUE
ENST00000489671 ENSG00000114126 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP2 protein_coding protein_coding 17.2795 10.83124 24.9558 0.7550352 0.5700402 1.203423 4.3836281 2.3342081 6.3978497 0.4285905 0.1369563 1.450740 0.27718333 0.223466667 0.25636667 0.032900000 7.798231e-01 2.365459e-44 FALSE TRUE
ENST00000499676 ENSG00000114126 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP2 protein_coding protein_coding 17.2795 10.83124 24.9558 0.7550352 0.5700402 1.203423 1.1622373 2.3909436 0.0000000 0.2923854 0.0000000 -7.907458 0.12741250 0.219300000 0.00000000 -0.219300000 2.365459e-44 2.365459e-44 FALSE TRUE
MSTRG.23837.12 ENSG00000114126 HEK293_OSMI2_2hA HEK293_TMG_2hB TFDP2 protein_coding   17.2795 10.83124 24.9558 0.7550352 0.5700402 1.203423 0.9752007 0.6559443 1.5635574 0.3295680 0.7897464 1.240556 0.05828750 0.063066667 0.06376667 0.000700000 1.000000e+00 2.365459e-44 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114126 E001 0.1482932 0.0410663730 2.756685e-01   3 141944428 141944434 7 - 0.000 0.169 11.699
ENSG00000114126 E002 93.4810356 0.0054978758 8.481528e-29 1.285440e-26 3 141944435 141944888 454 - 1.605 2.265 2.223
ENSG00000114126 E003 71.3872955 0.0014431640 1.138184e-24 1.205330e-22 3 141944889 141945038 150 - 1.572 2.114 1.827
ENSG00000114126 E004 972.1251780 0.0069584703 4.835353e-09 6.327138e-08 3 141945039 141951501 6463 - 2.860 3.117 0.855
ENSG00000114126 E005 135.8038299 0.0002497563 1.398081e-02 3.818218e-02 3 141951502 141952142 641 - 2.120 2.122 0.006
ENSG00000114126 E006 66.3524680 0.0004755668 5.761124e-03 1.798424e-02 3 141952143 141952275 133 - 1.828 1.780 -0.162
ENSG00000114126 E007 63.7519034 0.0037224752 6.337473e-04 2.657639e-03 3 141952276 141952473 198 - 1.831 1.717 -0.384
ENSG00000114126 E008 15.8100544 0.0041621012 1.349944e-01 2.410816e-01 3 141952474 141952480 7 - 1.235 1.171 -0.225
ENSG00000114126 E009 18.5717462 0.0052176525 4.172077e-02 9.422719e-02 3 141952481 141952495 15 - 1.316 1.211 -0.371
ENSG00000114126 E010 142.3874169 0.0127197074 5.357321e-01 6.675316e-01 3 141952496 141952696 201 - 2.093 2.218 0.417
ENSG00000114126 E011 1.2898899 0.0102532306 1.312502e-01 2.358913e-01 3 141952829 141952910 82 - 0.221 0.530 1.843
ENSG00000114126 E012 148.7408961 0.0079737873 4.502036e-01 5.913493e-01 3 141952911 141953016 106 - 2.112 2.236 0.416
ENSG00000114126 E013 153.3151691 0.0023416256 7.239835e-01 8.176440e-01 3 141959674 141959799 126 - 2.136 2.229 0.311
ENSG00000114126 E014 86.5505591 0.0042740497 7.554322e-01 8.407660e-01 3 141959800 141959840 41 - 1.903 1.969 0.223
ENSG00000114126 E015 65.0603736 0.0065368182 4.300691e-01 5.727090e-01 3 141963812 141963819 8 - 1.792 1.829 0.123
ENSG00000114126 E016 79.7251394 0.0031408671 3.404551e-01 4.844030e-01 3 141963820 141963851 32 - 1.879 1.914 0.115
ENSG00000114126 E017 106.6367826 0.0031783143 2.043140e-02 5.239837e-02 3 141963852 141963963 112 - 2.025 2.002 -0.076
ENSG00000114126 E018 80.3790725 0.0030515836 1.398962e-01 2.478814e-01 3 141970073 141970141 69 - 1.892 1.899 0.024
ENSG00000114126 E019 57.0108569 0.0012791663 1.101546e-02 3.119864e-02 3 141974048 141974066 19 - 1.765 1.713 -0.176
ENSG00000114126 E020 67.6350150 0.0003895002 1.105557e-04 5.704601e-04 3 141974067 141974104 38 - 1.853 1.755 -0.331
ENSG00000114126 E021 88.1220460 0.0003024319 5.747358e-07 5.026637e-06 3 141974105 141974191 87 - 1.975 1.853 -0.411
ENSG00000114126 E022 17.8795693 0.0013043283 4.759157e-02 1.048979e-01 3 141974192 141974194 3 - 1.293 1.199 -0.331
ENSG00000114126 E023 58.2534630 0.0003990470 1.343531e-03 5.121493e-03 3 141978520 141978536 17 - 1.783 1.705 -0.264
ENSG00000114126 E024 75.9497017 0.0003313420 1.553953e-03 5.810440e-03 3 141978537 141978587 51 - 1.890 1.835 -0.188
ENSG00000114126 E025 102.1416014 0.0002854327 1.306848e-06 1.058570e-05 3 141978588 141978682 95 - 2.031 1.930 -0.340
ENSG00000114126 E026 0.2214452 0.0421193404 2.728307e-01   3 141978683 141978688 6 - 0.000 0.170 11.736
ENSG00000114126 E027 0.0000000       3 141989067 141989514 448 -      
ENSG00000114126 E028 62.5349588 0.0004033630 1.667516e-04 8.211962e-04 3 141993538 141993572 35 - 1.818 1.717 -0.341
ENSG00000114126 E029 61.6103373 0.0004036038 5.497586e-04 2.345935e-03 3 141993573 141993585 13 - 1.807 1.721 -0.292
ENSG00000114126 E030 0.5944058 0.4062505212 3.822717e-01 5.265025e-01 3 141994270 141995019 750 - 0.087 0.302 2.173
ENSG00000114126 E031 67.6462777 0.0003950209 8.415399e-06 5.686924e-05 3 141995020 141995062 43 - 1.860 1.733 -0.429
ENSG00000114126 E032 51.3423658 0.0004552149 1.209108e-04 6.181841e-04 3 141995063 141995070 8 - 1.743 1.619 -0.420
ENSG00000114126 E033 62.7682133 0.0004222461 2.061514e-05 1.274966e-04 3 141995071 141995095 25 - 1.829 1.705 -0.421
ENSG00000114126 E034 75.6532048 0.0004259376 1.266628e-07 1.261613e-06 3 141995096 141995141 46 - 1.919 1.766 -0.517
ENSG00000114126 E035 0.0000000       3 141995142 141995229 88 -      
ENSG00000114126 E036 3.2526545 0.0263656678 2.738254e-01 4.129188e-01 3 142000252 142000324 73 - 0.658 0.530 -0.571
ENSG00000114126 E037 1.5326577 0.3625726290 2.610809e-01 3.987053e-01 3 142000325 142000354 30 - 0.479 0.170 -2.067
ENSG00000114126 E038 107.3824006 0.0010449599 2.916310e-08 3.289783e-07 3 142005441 142005544 104 - 2.064 1.925 -0.467
ENSG00000114126 E039 10.3371040 0.0327099761 9.600415e-02 1.843740e-01 3 142028579 142028665 87 - 1.083 0.916 -0.616
ENSG00000114126 E040 0.1451727 0.0433206838 8.667827e-01   3 142029042 142029157 116 - 0.087 0.000 -9.791
ENSG00000114126 E041 11.0919894 0.0015368951 1.273144e-04 6.470127e-04 3 142054115 142054149 35 - 1.162 0.796 -1.363
ENSG00000114126 E042 0.0000000       3 142090792 142090838 47 -      
ENSG00000114126 E043 0.4386386 0.1521298771 1.000000e+00 1.000000e+00 3 142093031 142093060 30 - 0.159 0.168 0.098
ENSG00000114126 E044 69.4855007 0.0004834615 1.310210e-07 1.301533e-06 3 142093061 142093127 67 - 1.885 1.721 -0.556
ENSG00000114126 E045 53.1309288 0.0006041826 2.183088e-05 1.341310e-04 3 142101735 142101774 40 - 1.767 1.624 -0.484
ENSG00000114126 E046 46.4273379 0.0004504910 3.917800e-04 1.743108e-03 3 142101775 142101841 67 - 1.699 1.583 -0.395
ENSG00000114126 E047 0.0000000       3 142126149 142126370 222 -      
ENSG00000114126 E048 48.7696700 0.0005343096 3.552061e-06 2.615443e-05 3 142149183 142149544 362 - 1.732 1.555 -0.603