ENSG00000114120

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324194 ENSG00000114120 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A36 protein_coding protein_coding 19.40202 3.571243 36.07406 0.427263 1.053923 3.332829 7.9797683 1.37549357 12.197478 0.28441241 0.4069898 3.139293 0.43597917 0.41350000 0.33930000 -0.07420000 8.671141e-01 4.425306e-05 FALSE TRUE
ENST00000393015 ENSG00000114120 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A36 protein_coding processed_transcript 19.40202 3.571243 36.07406 0.427263 1.053923 3.332829 1.6868151 0.00000000 4.168722 0.00000000 1.0550160 8.706918 0.04832917 0.00000000 0.11740000 0.11740000 4.425306e-05 4.425306e-05 FALSE TRUE
ENST00000502866 ENSG00000114120 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A36 protein_coding retained_intron 19.40202 3.571243 36.07406 0.427263 1.053923 3.332829 3.2311979 0.19999071 7.420645 0.04981336 1.1075667 5.145090 0.11443333 0.05960000 0.20433333 0.14473333 1.193782e-03 4.425306e-05   FALSE
ENST00000507429 ENSG00000114120 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A36 protein_coding protein_coding 19.40202 3.571243 36.07406 0.427263 1.053923 3.332829 1.6798682 0.11452941 3.829391 0.08022426 0.1964181 4.946319 0.06345417 0.02893333 0.10606667 0.07713333 9.289653e-03 4.425306e-05 FALSE FALSE
ENST00000511757 ENSG00000114120 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A36 protein_coding retained_intron 19.40202 3.571243 36.07406 0.427263 1.053923 3.332829 2.0684703 0.16633720 3.812370 0.06081414 0.3789441 4.438059 0.09678333 0.04720000 0.10530000 0.05810000 6.611948e-02 4.425306e-05 FALSE TRUE
ENST00000512023 ENSG00000114120 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A36 protein_coding nonsense_mediated_decay 19.40202 3.571243 36.07406 0.427263 1.053923 3.332829 1.0808385 0.09058934 2.353976 0.05501248 0.6013333 4.554666 0.05235833 0.02796667 0.06443333 0.03646667 4.006355e-01 4.425306e-05 FALSE TRUE
ENST00000514629 ENSG00000114120 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A36 protein_coding retained_intron 19.40202 3.571243 36.07406 0.427263 1.053923 3.332829 0.2586853 1.05162086 0.000000 0.61512683 0.0000000 -6.730125 0.07809167 0.26266667 0.00000000 -0.26266667 2.521606e-02 4.425306e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114120 E001 1.1822706 0.0855807926 3.748589e-01 5.193118e-01 3 140941830 140941835 6 + 0.197 0.504 1.935
ENSG00000114120 E002 1.7734567 0.0680359456 7.011397e-01 8.004098e-01 3 140941836 140941840 5 + 0.291 0.505 1.201
ENSG00000114120 E003 1.7734567 0.0680359456 7.011397e-01 8.004098e-01 3 140941841 140941842 2 + 0.291 0.505 1.201
ENSG00000114120 E004 4.8811305 0.0032247483 2.320355e-01 3.648598e-01 3 140941843 140941852 10 + 0.598 0.507 -0.421
ENSG00000114120 E005 12.0921834 0.0209087927 7.895637e-02 1.578519e-01 3 140941853 140941867 15 + 0.922 0.813 -0.418
ENSG00000114120 E006 20.8755343 0.0109890643 2.918585e-02 7.035932e-02 3 140941868 140941886 19 + 1.134 1.038 -0.345
ENSG00000114120 E007 22.9257206 0.0257743758 3.882928e-02 8.886528e-02 3 140941887 140941894 8 + 1.171 1.078 -0.337
ENSG00000114120 E008 24.6145849 0.0275788245 7.473760e-02 1.511112e-01 3 140941895 140941900 6 + 1.196 1.151 -0.160
ENSG00000114120 E009 54.4216201 0.0148911900 1.980820e-02 5.107599e-02 3 140941901 140941993 93 + 1.521 1.489 -0.110
ENSG00000114120 E010 72.7845671 0.0100176219 3.046802e-02 7.288066e-02 3 140941994 140942095 102 + 1.639 1.665 0.089
ENSG00000114120 E011 5.1518946 0.0030945518 2.126160e-01 3.416351e-01 3 140942462 140942729 268 + 0.609 0.507 -0.466
ENSG00000114120 E012 0.1515154 0.0430385764 7.703713e-01   3 140956525 140956526 2 + 0.040 0.000 -23.164
ENSG00000114120 E013 79.6966627 0.0068650907 7.454448e-02 1.508107e-01 3 140956527 140956626 100 + 1.671 1.742 0.242
ENSG00000114120 E014 69.1884463 0.0011510795 1.627561e-02 4.333431e-02 3 140956627 140956691 65 + 1.613 1.656 0.145
ENSG00000114120 E015 1.7036261 0.0079717424 5.796086e-01 7.044569e-01 3 140956692 140957069 378 + 0.270 0.507 1.364
ENSG00000114120 E016 71.9523293 0.0006735846 9.592856e-03 2.776311e-02 3 140959463 140959540 78 + 1.631 1.667 0.120
ENSG00000114120 E017 77.1103433 0.0003757414 1.639963e-02 4.361486e-02 3 140963127 140963227 101 + 1.659 1.716 0.193
ENSG00000114120 E018 138.7233710 0.0018405893 5.775221e-14 1.698383e-12 3 140963228 140966211 2984 + 1.934 1.696 -0.803
ENSG00000114120 E019 15.7063915 0.0012306764 5.286651e-04 2.266595e-03 3 140966348 140966434 87 + 1.032 0.636 -1.554
ENSG00000114120 E020 16.4367864 0.0055090604 4.321935e-04 1.898219e-03 3 140966780 140966933 154 + 1.051 0.636 -1.623
ENSG00000114120 E021 24.6288479 0.0009675763 8.341778e-03 2.464598e-02 3 140966934 140966999 66 + 1.197 1.082 -0.411
ENSG00000114120 E022 25.0700058 0.0057500930 4.410192e-03 1.429252e-02 3 140967000 140967036 37 + 1.207 1.040 -0.600
ENSG00000114120 E023 3.9169822 0.0042667783 4.488817e-01 5.901005e-01 3 140968683 140968730 48 + 0.518 0.507 -0.051
ENSG00000114120 E024 35.2087172 0.0028932594 3.108786e-05 1.843350e-04 3 140970365 140970926 562 + 1.355 1.082 -0.966
ENSG00000114120 E025 78.9065726 0.0003768616 1.416784e-04 7.107444e-04 3 140970927 140970993 67 + 1.677 1.634 -0.146
ENSG00000114120 E026 0.4502799 0.0272637647 1.000000e+00 1.000000e+00 3 140973666 140973715 50 + 0.110 0.000 -24.749
ENSG00000114120 E027 177.6524683 0.0031610602 8.118496e-05 4.336006e-04 3 140973716 140974005 290 + 2.020 2.026 0.020
ENSG00000114120 E028 51.3769940 0.0005059544 6.730527e-04 2.799970e-03 3 140976260 140976262 3 + 1.498 1.423 -0.260
ENSG00000114120 E029 1257.1214544 0.0140438721 5.547870e-10 8.624876e-09 3 140976263 140980995 4733 + 2.818 3.176 1.189