ENSG00000114107

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264982 ENSG00000114107 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP70 protein_coding protein_coding 6.708771 2.482919 10.79422 0.2864952 0.2038759 2.115686 2.4601472 1.07934634 3.9447255 0.17437279 0.04786197 1.8601148 0.41936667 0.43253333 0.36570000 -0.06683333 0.452838783 0.002646986 FALSE TRUE
ENST00000459695 ENSG00000114107 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP70 protein_coding protein_coding 6.708771 2.482919 10.79422 0.2864952 0.2038759 2.115686 0.4175332 0.33842527 0.3113602 0.04720204 0.12529392 -0.1166582 0.08497500 0.13663333 0.02846667 -0.10816667 0.002646986 0.002646986   FALSE
ENST00000462419 ENSG00000114107 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP70 protein_coding protein_coding 6.708771 2.482919 10.79422 0.2864952 0.2038759 2.115686 0.4379267 0.03907617 0.9812755 0.03907617 0.18949248 4.3361915 0.04377500 0.01280000 0.09036667 0.07756667 0.008239816 0.002646986 FALSE FALSE
ENST00000464035 ENSG00000114107 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP70 protein_coding protein_coding 6.708771 2.482919 10.79422 0.2864952 0.2038759 2.115686 1.0727512 0.48707005 1.5574774 0.10011187 0.19059016 1.6569235 0.14455000 0.19260000 0.14463333 -0.04796667 0.542093797 0.002646986 FALSE TRUE
ENST00000474781 ENSG00000114107 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP70 protein_coding protein_coding 6.708771 2.482919 10.79422 0.2864952 0.2038759 2.115686 0.5344137 0.19762351 1.0591033 0.06087606 0.34208290 2.3643596 0.06497917 0.08630000 0.09936667 0.01306667 0.976473960 0.002646986 FALSE TRUE
ENST00000481834 ENSG00000114107 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP70 protein_coding protein_coding 6.708771 2.482919 10.79422 0.2864952 0.2038759 2.115686 0.6065294 0.05604385 0.9120410 0.02924833 0.52420679 3.8033349 0.07403750 0.02290000 0.08280000 0.05990000 0.652035545 0.002646986 FALSE TRUE
ENST00000484888 ENSG00000114107 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP70 protein_coding protein_coding 6.708771 2.482919 10.79422 0.2864952 0.2038759 2.115686 0.8130480 0.19351260 1.4457065 0.12766604 0.33741702 2.8385294 0.11245417 0.08036667 0.13443333 0.05406667 0.590035310 0.002646986 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114107 E001 29.4028617 0.0008185445 0.0000517188 0.0002902885 3 138494344 138494757 414 - 1.322 1.606 0.980
ENSG00000114107 E002 22.8028495 0.0008738483 0.0153857069 0.0413660505 3 138494758 138495002 245 - 1.240 1.439 0.694
ENSG00000114107 E003 7.6617170 0.0021895218 0.3303326152 0.4739297136 3 138495003 138495012 10 - 0.831 0.961 0.497
ENSG00000114107 E004 14.5763138 0.0029729684 0.0025107446 0.0087961725 3 138495013 138495076 64 - 1.035 1.329 1.050
ENSG00000114107 E005 2.3520672 0.0074472377 0.0410810459 0.0930346536 3 138496910 138497089 180 - 0.352 0.706 1.709
ENSG00000114107 E006 3.2775173 0.0049472669 0.0297008875 0.0713718690 3 138497090 138497327 238 - 0.458 0.809 1.538
ENSG00000114107 E007 23.2505191 0.0207370016 0.1876003406 0.3107269031 3 138498031 138498110 80 - 1.270 1.406 0.473
ENSG00000114107 E008 2.2258129 0.1599125779 0.6652801844 0.7729668398 3 138499884 138500109 226 - 0.482 0.368 -0.605
ENSG00000114107 E009 35.3559937 0.0041992444 0.0146825457 0.0397729957 3 138500110 138500224 115 - 1.437 1.613 0.600
ENSG00000114107 E010 42.8706787 0.0107478200 0.1445613354 0.2542350802 3 138500399 138500567 169 - 1.536 1.651 0.392
ENSG00000114107 E011 36.7130744 0.0008461966 0.8110637087 0.8801563589 3 138500735 138500881 147 - 1.488 1.508 0.069
ENSG00000114107 E012 40.6848942 0.0005758957 0.2771859247 0.4167023635 3 138505295 138505465 171 - 1.518 1.591 0.250
ENSG00000114107 E013 32.1394424 0.0007511076 0.3548801398 0.4992201634 3 138508439 138508544 106 - 1.419 1.490 0.242
ENSG00000114107 E014 26.8741085 0.0007395498 0.6611228522 0.7696470374 3 138525490 138525564 75 - 1.356 1.394 0.132
ENSG00000114107 E015 22.0491242 0.0008996099 0.8471261230 0.9050529092 3 138529199 138529228 30 - 1.284 1.271 -0.048
ENSG00000114107 E016 25.3844841 0.0008287094 0.6812964723 0.7850224208 3 138529229 138529287 59 - 1.347 1.316 -0.108
ENSG00000114107 E017 26.3168261 0.0007162959 0.5559723252 0.6847365589 3 138529375 138529462 88 - 1.344 1.394 0.174
ENSG00000114107 E018 0.2903454 0.3583782486 1.0000000000   3 138531507 138531623 117 - 0.118 0.000 -8.597
ENSG00000114107 E019 15.4143062 0.0012497634 0.5158209550 0.6504408002 3 138532514 138532570 57 - 1.114 1.184 0.248
ENSG00000114107 E020 7.9891417 0.0025484586 0.0036023021 0.0120173834 3 138536919 138537177 259 - 0.766 1.122 1.339
ENSG00000114107 E021 43.5309269 0.0005401162 0.7413512101 0.8305609149 3 138537178 138537347 170 - 1.559 1.584 0.083
ENSG00000114107 E022 39.7495678 0.0021376990 0.0336865370 0.0791297380 3 138570318 138570434 117 - 1.559 1.405 -0.529
ENSG00000114107 E023 34.6822165 0.0006017134 0.0371626027 0.0857835727 3 138570435 138570498 64 - 1.499 1.343 -0.538
ENSG00000114107 E024 44.8400883 0.0005476141 0.0267166806 0.0654019949 3 138571034 138571157 124 - 1.605 1.460 -0.498
ENSG00000114107 E025 43.9118724 0.0014249372 0.0180352708 0.0472080241 3 138571266 138571353 88 - 1.600 1.439 -0.553
ENSG00000114107 E026 27.7930622 0.0007391583 0.0416065182 0.0940129060 3 138571354 138571356 3 - 1.409 1.238 -0.597
ENSG00000114107 E027 37.4132655 0.0005468817 0.0410393483 0.0929557326 3 138572859 138572914 56 - 1.528 1.382 -0.505
ENSG00000114107 E028 22.4427615 0.0026639861 0.1799960798 0.3011757196 3 138572915 138572932 18 - 1.308 1.184 -0.438
ENSG00000114107 E029 8.3928907 0.0021223721 0.4873166148 0.6249833852 3 138572933 138572984 52 - 0.869 0.962 0.350
ENSG00000114107 E030 26.7110351 0.0011756532 0.0535631523 0.1154869746 3 138591854 138591865 12 - 1.387 1.221 -0.582
ENSG00000114107 E031 38.5806114 0.0006561693 0.0028116566 0.0097090867 3 138591866 138591956 91 - 1.552 1.330 -0.765
ENSG00000114107 E032 0.1451727 0.0435250229 1.0000000000   3 138592981 138593080 100 - 0.063 0.000 -7.602
ENSG00000114107 E033 0.7687379 0.1497066218 0.9241618059 0.9562336171 3 138593709 138594197 489 - 0.210 0.225 0.127
ENSG00000114107 E034 21.8298862 0.0044449780 0.0007581959 0.0031087773 3 138594198 138594345 148 - 1.331 0.962 -1.324
ENSG00000114107 E035 0.0000000       3 138594444 138594538 95 -