ENSG00000114054

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251654 ENSG00000114054 HEK293_OSMI2_2hA HEK293_TMG_2hB PCCB protein_coding protein_coding 52.46131 54.98023 56.87126 12.42134 0.7265726 0.04877817 48.0661 52.09178 51.18872 11.40307 0.8343028 -0.02522501 0.9168708 0.9502333 0.9 -0.05023333 0.006359822 0.0001913015 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114054 E001 1.7068735 0.0772798166 1.170810e-01 2.157818e-01 3 136250339 136250339 1 + 0.583 0.279 -1.652
ENSG00000114054 E002 12.2671996 0.0021460555 7.490988e-01 8.361340e-01 3 136250340 136250354 15 + 1.147 1.124 -0.086
ENSG00000114054 E003 14.6567448 0.0013521049 4.012115e-01 5.449132e-01 3 136250355 136250357 3 + 1.245 1.179 -0.233
ENSG00000114054 E004 21.7306741 0.0008600319 7.212379e-01 8.156799e-01 3 136250358 136250358 1 + 1.345 1.377 0.109
ENSG00000114054 E005 57.6451383 0.0004234222 3.461185e-01 4.902843e-01 3 136250359 136250368 10 + 1.797 1.759 -0.129
ENSG00000114054 E006 80.1047585 0.0003939315 4.285171e-01 5.712566e-01 3 136250369 136250374 6 + 1.931 1.904 -0.089
ENSG00000114054 E007 108.1066849 0.0005317627 1.286224e-01 2.322405e-01 3 136250375 136250390 16 + 2.071 2.021 -0.166
ENSG00000114054 E008 207.7858703 0.0003770177 1.276173e-02 3.535279e-02 3 136250391 136250468 78 + 2.359 2.298 -0.203
ENSG00000114054 E009 273.0888627 0.0018489950 1.090844e-01 2.041956e-01 3 136250469 136250558 90 + 2.469 2.417 -0.172
ENSG00000114054 E010 0.0000000       3 136251243 136251292 50 +      
ENSG00000114054 E011 0.5879639 0.0197633122 2.442072e-01 3.791536e-01 3 136252303 136252389 87 + 0.313 0.114 -1.817
ENSG00000114054 E012 0.1515154 0.0467392653 4.435180e-01   3 136255307 136255317 11 + 0.131 0.000 -11.376
ENSG00000114054 E013 0.1515154 0.0467392653 4.435180e-01   3 136255318 136255320 3 + 0.131 0.000 -11.376
ENSG00000114054 E014 0.1515154 0.0467392653 4.435180e-01   3 136255321 136255384 64 + 0.131 0.000 -11.376
ENSG00000114054 E015 0.0000000       3 136255385 136255417 33 +      
ENSG00000114054 E016 0.0000000       3 136255418 136255533 116 +      
ENSG00000114054 E017 159.6055001 0.0011904498 1.844141e-01 3.067639e-01 3 136255856 136255856 1 + 2.234 2.193 -0.137
ENSG00000114054 E018 354.3927674 0.0001761329 9.420243e-02 1.817053e-01 3 136255857 136255975 119 + 2.572 2.544 -0.094
ENSG00000114054 E019 0.3332198 0.0329475261 9.272949e-01   3 136256125 136256270 146 + 0.131 0.114 -0.230
ENSG00000114054 E020 302.6734241 0.0002602648 4.731920e-01 6.122024e-01 3 136256555 136256623 69 + 2.494 2.482 -0.041
ENSG00000114054 E021 1.1135859 0.0129272744 3.069437e-02 7.332025e-02 3 136259176 136259235 60 + 0.493 0.114 -2.814
ENSG00000114054 E022 0.1472490 0.0459414268 4.438988e-01   3 136260150 136260262 113 + 0.131 0.000 -11.376
ENSG00000114054 E023 0.5117019 0.0293499043 1.140540e-01 2.114286e-01 3 136260263 136260355 93 + 0.000 0.279 12.224
ENSG00000114054 E024 0.5149111 0.0209859364 6.672501e-01 7.745525e-01 3 136260356 136260478 123 + 0.131 0.204 0.770
ENSG00000114054 E025 302.4889400 0.0005712885 7.044741e-02 1.440856e-01 3 136260479 136260535 57 + 2.509 2.467 -0.138
ENSG00000114054 E026 225.8133879 0.0003488309 2.703753e-04 1.259170e-03 3 136261952 136261963 12 + 2.408 2.322 -0.288
ENSG00000114054 E027 449.0467375 0.0019014836 8.386628e-02 1.656057e-01 3 136261964 136262065 102 + 2.684 2.629 -0.186
ENSG00000114054 E028 456.8076149 0.0020819703 1.410422e-01 2.494680e-01 3 136283837 136283947 111 + 2.689 2.638 -0.168
ENSG00000114054 E029 494.0471872 0.0006498675 9.448489e-02 1.821037e-01 3 136293756 136293864 109 + 2.717 2.683 -0.114
ENSG00000114054 E030 506.8114497 0.0001380195 3.332187e-01 4.769119e-01 3 136297952 136298072 121 + 2.701 2.720 0.066
ENSG00000114054 E031 430.5191300 0.0001368442 1.032383e-01 1.954042e-01 3 136301030 136301111 82 + 2.655 2.632 -0.078
ENSG00000114054 E032 542.5454956 0.0005953337 3.462901e-01 4.904357e-01 3 136316941 136317064 124 + 2.728 2.747 0.065
ENSG00000114054 E033 11.7429638 0.0625934317 4.809817e-01 6.192147e-01 3 136326326 136326385 60 + 1.148 1.085 -0.228
ENSG00000114054 E034 494.8121723 0.0003739916 1.326594e-04 6.705067e-04 3 136326803 136326910 108 + 2.658 2.729 0.238
ENSG00000114054 E035 8.2787331 0.0467865667 1.119152e-01 2.083776e-01 3 136326911 136327154 244 + 1.090 0.830 -0.972
ENSG00000114054 E036 493.9693453 0.0018877739 1.356639e-04 6.841954e-04 3 136327155 136327255 101 + 2.636 2.733 0.325
ENSG00000114054 E037 458.4177436 0.0015486216 4.460475e-04 1.951646e-03 3 136327634 136327732 99 + 2.612 2.697 0.285
ENSG00000114054 E038 427.9396822 0.0007451300 4.833006e-08 5.228406e-07 3 136328758 136328857 100 + 2.564 2.682 0.392
ENSG00000114054 E039 367.2763412 0.0013676007 1.329204e-03 5.072800e-03 3 136329905 136329984 80 + 2.520 2.601 0.271
ENSG00000114054 E040 370.4772631 0.0017448205 8.448473e-01 9.034522e-01 3 136329985 136330328 344 + 2.575 2.570 -0.016
ENSG00000114054 E041 10.8949375 0.0015637005 3.918574e-04 1.743370e-03 3 136333402 136333641 240 + 1.245 0.898 -1.262
ENSG00000114054 E042 1.1834165 0.0107233843 1.455177e-02 3.948027e-02 3 136333642 136333650 9 + 0.540 0.114 -3.039
ENSG00000114054 E043 12.2884937 0.0032885328 2.080395e-09 2.902456e-08 3 136333651 136334279 629 + 1.379 0.785 -2.168
ENSG00000114054 E044 101.7713239 0.0339898727 8.634912e-04 3.485890e-03 3 136334280 136337896 3617 + 2.180 1.819 -1.210
ENSG00000114054 E045 0.8909922 0.0789906974 2.483597e-01 3.839894e-01 3 136350809 136350900 92 + 0.131 0.343 1.771