ENSG00000114030

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344337 ENSG00000114030 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA1 protein_coding protein_coding 37.71165 24.98686 49.57378 3.184505 1.771998 0.9881214 6.891669 4.7894792 10.150900 0.6925755 0.3435892 1.0820785 0.1760708 0.19446667 0.2048333 0.01036667 8.864712e-01 1.26536e-08 FALSE TRUE
ENST00000494339 ENSG00000114030 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA1 protein_coding nonsense_mediated_decay 37.71165 24.98686 49.57378 3.184505 1.771998 0.9881214 5.144739 0.6484117 8.872655 0.2262196 0.6880025 3.7539292 0.1234292 0.02513333 0.1800333 0.15490000 1.575449e-08 1.26536e-08 FALSE TRUE
MSTRG.23543.2 ENSG00000114030 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA1 protein_coding   37.71165 24.98686 49.57378 3.184505 1.771998 0.9881214 23.487113 18.7084882 26.841908 2.6056650 1.0063950 0.5205607 0.6440208 0.74620000 0.5420667 -0.20413333 1.265360e-08 1.26536e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114030 E001 669.3576684 0.0081654463 2.814456e-01 4.213544e-01 3 122421902 122425679 3778 - 2.845 2.791 -0.178
ENSG00000114030 E002 388.6391906 0.0011760375 4.400784e-12 9.702262e-11 3 122425680 122426103 424 - 2.515 2.676 0.536
ENSG00000114030 E003 680.4544600 0.0001353056 1.920042e-24 1.990948e-22 3 122426104 122426631 528 - 2.770 2.909 0.463
ENSG00000114030 E004 488.7101775 0.0001377654 3.464151e-07 3.164344e-06 3 122426632 122426953 322 - 2.654 2.736 0.272
ENSG00000114030 E005 177.6317135 0.0002871400 5.868803e-04 2.485196e-03 3 122426954 122426984 31 - 2.209 2.301 0.308
ENSG00000114030 E006 386.3002020 0.0008277943 3.416855e-05 2.003755e-04 3 122426985 122427172 188 - 2.548 2.635 0.292
ENSG00000114030 E007 333.1385177 0.0002447203 1.063647e-03 4.179543e-03 3 122427538 122427716 179 - 2.496 2.561 0.217
ENSG00000114030 E008 287.4510003 0.0002398280 5.732533e-02 1.220278e-01 3 122433661 122433788 128 - 2.445 2.485 0.135
ENSG00000114030 E009 267.7464936 0.0010137002 8.190916e-01 8.857596e-01 3 122437170 122437295 126 - 2.434 2.428 -0.021
ENSG00000114030 E010 135.7822455 0.0094605042 7.136825e-01 8.100994e-01 3 122442038 122442047 10 - 2.144 2.124 -0.068
ENSG00000114030 E011 199.3884361 0.0031824256 4.526449e-01 5.934862e-01 3 122442048 122442116 69 - 2.315 2.281 -0.114
ENSG00000114030 E012 271.3176552 0.0023119379 2.648007e-01 4.027983e-01 3 122449574 122449737 164 - 2.451 2.408 -0.142
ENSG00000114030 E013 139.3787981 0.0015806608 2.968835e-02 7.134718e-02 3 122451534 122451584 51 - 2.180 2.098 -0.273
ENSG00000114030 E014 152.0230476 0.0002222847 1.143401e-02 3.219444e-02 3 122451585 122451633 49 - 2.215 2.139 -0.254
ENSG00000114030 E015 107.5757478 0.0002955793 6.050272e-02 1.274794e-01 3 122451976 122451984 9 - 2.063 1.995 -0.225
ENSG00000114030 E016 121.1414174 0.0002565918 3.195540e-02 7.577201e-02 3 122451985 122451989 5 - 2.117 2.045 -0.240
ENSG00000114030 E017 193.3980490 0.0002774315 4.037314e-03 1.324680e-02 3 122451990 122452064 75 - 2.321 2.243 -0.260
ENSG00000114030 E018 144.5580661 0.0002424759 1.512159e-05 9.644289e-05 3 122453870 122453909 40 - 2.214 2.079 -0.450
ENSG00000114030 E019 214.3403764 0.0001823466 1.584772e-03 5.909465e-03 3 122453910 122454001 92 - 2.365 2.285 -0.267
ENSG00000114030 E020 9.5583126 0.0017813147 5.601240e-04 2.385384e-03 3 122457726 122457848 123 - 1.148 0.744 -1.522
ENSG00000114030 E021 7.9059788 0.0021521029 2.802125e-02 6.805549e-02 3 122459439 122459681 243 - 1.041 0.775 -1.010
ENSG00000114030 E022 3.5418158 0.0117334183 3.651721e-02 8.456272e-02 3 122459682 122459773 92 - 0.768 0.424 -1.556
ENSG00000114030 E023 15.4680982 0.0581861148 1.824110e-01 3.042464e-01 3 122459774 122460657 884 - 1.283 1.079 -0.727
ENSG00000114030 E024 240.9732223 0.0027588376 3.920522e-01 5.359932e-01 3 122461224 122461318 95 - 2.397 2.364 -0.110
ENSG00000114030 E025 211.1726251 0.0006089497 1.280703e-02 3.546169e-02 3 122463942 122464041 100 - 2.356 2.287 -0.230
ENSG00000114030 E026 0.3729606 0.0424614596 7.185703e-01 8.136279e-01 3 122464143 122464259 117 - 0.099 0.151 0.695
ENSG00000114030 E027 261.1008020 0.0001910050 2.586330e-05 1.562662e-04 3 122467322 122467429 108 - 2.457 2.359 -0.326
ENSG00000114030 E028 269.0558104 0.0007236564 1.078735e-07 1.089123e-06 3 122496437 122496570 134 - 2.484 2.346 -0.460
ENSG00000114030 E029 0.2944980 0.3873745298 4.911624e-01   3 122496571 122496637 67 - 0.179 0.000 -9.874
ENSG00000114030 E030 0.1482932 0.0411597534 3.043385e-01   3 122514465 122514756 292 - 0.000 0.150 9.969
ENSG00000114030 E031 139.9109786 0.0018148020 2.175244e-08 2.519029e-07 3 122514757 122514839 83 - 2.226 2.012 -0.716
ENSG00000114030 E032 76.1640457 0.0005278394 4.845684e-09 6.339343e-08 3 122514840 122514874 35 - 1.979 1.721 -0.868
ENSG00000114030 E033 68.1832740 0.0003615845 1.087119e-10 1.907488e-09 3 122514875 122514945 71 - 1.942 1.643 -1.010