ENSG00000114026

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302036 ENSG00000114026 HEK293_OSMI2_2hA HEK293_TMG_2hB OGG1 protein_coding protein_coding 32.8627 63.27245 18.55642 2.910911 0.7313882 -1.76911 7.123604 11.397264 5.3253514 0.2796803 0.22264231 -1.096298 0.2408500 0.18073333 0.28780000 0.10706667 0.0002305757 0.0002305757 FALSE TRUE
ENST00000344629 ENSG00000114026 HEK293_OSMI2_2hA HEK293_TMG_2hB OGG1 protein_coding protein_coding 32.8627 63.27245 18.55642 2.910911 0.7313882 -1.76911 1.793312 3.274352 0.9021366 0.1922970 0.04234521 -1.848287 0.0553125 0.05176667 0.04886667 -0.00290000 0.8929606655 0.0002305757 FALSE TRUE
ENST00000383825 ENSG00000114026 HEK293_OSMI2_2hA HEK293_TMG_2hB OGG1 protein_coding processed_transcript 32.8627 63.27245 18.55642 2.910911 0.7313882 -1.76911 5.962796 11.215207 2.7687965 0.8472994 0.24404809 -2.014210 0.1814625 0.17830000 0.14976667 -0.02853333 0.6535097246 0.0002305757   FALSE
ENST00000416333 ENSG00000114026 HEK293_OSMI2_2hA HEK293_TMG_2hB OGG1 protein_coding protein_coding 32.8627 63.27245 18.55642 2.910911 0.7313882 -1.76911 3.269255 8.399791 1.2929998 1.0852877 0.58158184 -2.690233 0.0862750 0.13170000 0.06786667 -0.06383333 0.2180706856 0.0002305757 FALSE TRUE
ENST00000441094 ENSG00000114026 HEK293_OSMI2_2hA HEK293_TMG_2hB OGG1 protein_coding protein_coding 32.8627 63.27245 18.55642 2.910911 0.7313882 -1.76911 4.299838 9.560220 2.0566623 0.7295408 0.23425361 -2.211249 0.1162875 0.15066667 0.11023333 -0.04043333 0.0806168516 0.0002305757 FALSE TRUE
MSTRG.22448.11 ENSG00000114026 HEK293_OSMI2_2hA HEK293_TMG_2hB OGG1 protein_coding   32.8627 63.27245 18.55642 2.910911 0.7313882 -1.76911 4.955137 9.438734 2.9695923 1.2612567 0.23635635 -1.665006 0.1498875 0.14873333 0.15956667 0.01083333 0.8599189372 0.0002305757 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114026 E001 1.445660 0.0090306727 6.776257e-03 2.064126e-02 3 9749944 9749951 8 + 0.656 0.188 -2.708
ENSG00000114026 E002 6.574263 0.0216529265 9.070106e-05 4.783299e-04 3 9749952 9749980 29 + 1.144 0.612 -2.067
ENSG00000114026 E003 13.713973 0.0012666378 9.719300e-07 8.084353e-06 3 9749981 9750017 37 + 1.390 0.933 -1.637
ENSG00000114026 E004 37.928077 0.0010936490 1.204273e-06 9.831758e-06 3 9750018 9750071 54 + 1.713 1.410 -1.034
ENSG00000114026 E005 35.459954 0.0017464621 9.046288e-05 4.771933e-04 3 9750072 9750072 1 + 1.654 1.395 -0.889
ENSG00000114026 E006 52.827696 0.0005950100 1.042361e-03 4.105364e-03 3 9750073 9750082 10 + 1.768 1.587 -0.614
ENSG00000114026 E007 52.821150 0.0004905480 5.202710e-03 1.648224e-02 3 9750083 9750086 4 + 1.750 1.595 -0.527
ENSG00000114026 E008 90.998650 0.0007322434 5.097460e-02 1.109030e-01 3 9750087 9750160 74 + 1.933 1.844 -0.298
ENSG00000114026 E009 206.379355 0.0010613594 1.763822e-02 4.635704e-02 3 9750161 9750345 185 + 2.280 2.202 -0.258
ENSG00000114026 E010 126.063225 0.0003045501 3.479360e-02 8.125068e-02 3 9750346 9750354 9 + 2.070 1.990 -0.268
ENSG00000114026 E011 181.027373 0.0002469140 2.268541e-02 5.710399e-02 3 9750355 9750423 69 + 2.219 2.147 -0.242
ENSG00000114026 E012 6.523646 0.0026421409 8.732647e-02 1.710866e-01 3 9750665 9750944 280 + 0.965 0.740 -0.872
ENSG00000114026 E013 117.294790 0.0002776840 4.721827e-01 6.112389e-01 3 9750945 9750963 19 + 1.999 1.969 -0.102
ENSG00000114026 E014 233.316291 0.0002008415 5.187883e-01 6.529791e-01 3 9750964 9751078 115 + 2.289 2.269 -0.068
ENSG00000114026 E015 131.977733 0.0004044730 1.885454e-01 3.119050e-01 3 9751079 9751091 13 + 1.991 2.039 0.159
ENSG00000114026 E016 232.514232 0.0008535723 1.907569e-01 3.146978e-01 3 9751092 9751192 101 + 2.243 2.281 0.128
ENSG00000114026 E017 288.922878 0.0001585458 1.523004e-01 2.648217e-01 3 9751770 9751902 133 + 2.339 2.372 0.111
ENSG00000114026 E018 183.911735 0.0002603784 1.365451e-01 2.432489e-01 3 9751903 9751949 47 + 2.133 2.178 0.151
ENSG00000114026 E019 7.447061 0.0490883406 6.141017e-01 7.326595e-01 3 9751950 9752094 145 + 0.756 0.849 0.365
ENSG00000114026 E020 303.409427 0.0002517185 5.706545e-03 1.783444e-02 3 9754704 9754885 182 + 2.331 2.399 0.224
ENSG00000114026 E021 286.303523 0.0002868612 6.309618e-04 2.646930e-03 3 9756471 9756621 151 + 2.289 2.377 0.292
ENSG00000114026 E022 205.839289 0.0005557325 1.161999e-02 3.262790e-02 3 9756767 9756816 50 + 2.153 2.231 0.262
ENSG00000114026 E023 115.471478 0.0009889618 1.548634e-03 5.793181e-03 3 9756817 9757043 227 + 1.858 1.995 0.461
ENSG00000114026 E024 73.749252 0.0003866339 1.735388e-03 6.394199e-03 3 9757044 9757060 17 + 1.643 1.806 0.554
ENSG00000114026 E025 270.674052 0.0002153864 1.435701e-10 2.467918e-09 3 9757061 9757347 287 + 2.192 2.369 0.589
ENSG00000114026 E026 57.558661 0.0004390916 8.112367e-01 8.802056e-01 3 9757348 9759186 1839 + 1.687 1.671 -0.053
ENSG00000114026 E027 4.022203 0.0041411243 1.315268e-01 2.362642e-01 3 9759187 9759233 47 + 0.799 0.568 -0.971
ENSG00000114026 E028 9.750308 0.0154774688 2.680324e-03 9.314516e-03 3 9759234 9759286 53 + 1.196 0.833 -1.342
ENSG00000114026 E029 44.998360 0.0059804399 1.958862e-04 9.462986e-04 3 9759287 9762324 3038 + 1.755 1.505 -0.851
ENSG00000114026 E030 206.786163 0.0019571777 2.266180e-03 8.049214e-03 3 9765809 9766737 929 + 2.304 2.199 -0.352
ENSG00000114026 E031 3.612925 0.0055012933 5.561944e-02 1.190439e-01 3 9781513 9781600 88 + 0.799 0.500 -1.291
ENSG00000114026 E032 1.803770 0.0075669113 1.162167e-01 2.145783e-01 3 9787728 9788219 492 + 0.596 0.318 -1.445